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Murcko scaffold

Ring system with 3 rings and 23 atoms

22 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
22
With full pages
6
Scaffold SMILES

O=C(CNc1ccccc1)Nc1c[nH]n(-c2ccccc2)c1=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNc1ccccc1)Nc1c[nH]n(-c2ccccc2)c1=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(2-methoxy-N-methylsulfonylanilino)acetamide chemical structure, C21H24N4O5S, CAS 432020-24-1
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(2-methoxy-N-methylsulfonylanilino)acetamide
CAS 432020-24-1C21H24N4O5S
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(3-fluoro-N-methylsulfonylanilino)acetamide chemical structure, C20H21FN4O4S, CAS 678543-40-3
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(3-fluoro-N-methylsulfonylanilino)acetamide
CAS 678543-40-3C20H21FN4O4S
2-[3,4-Dimethyl(methylsulfonyl)anilino]-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide chemical structure, C22H26N4O4S, CAS 409354-32-1
2-[3,4-Dimethyl(methylsulfonyl)anilino]-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide
CAS 409354-32-1C22H26N4O4S
2-(5-Chloro-2-methoxy-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide chemical structure, C21H23ClN4O5S, CAS 409356-64-5
2-(5-Chloro-2-methoxy-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide
CAS 409356-64-5C21H23ClN4O5S
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-[N-methylsulfonyl-3-(trifluoromethyl)anilino]acetamide chemical structure, C21H21F3N4O4S, CAS 428474-34-4
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-[N-methylsulfonyl-3-(trifluoromethyl)anilino]acetamide
CAS 428474-34-4C21H21F3N4O4S
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(2-methoxy-5-methyl-N-methylsulfonylanilino)acetamide chemical structure, C22H26N4O5S, CAS 6467-37-4
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(2-methoxy-5-methyl-N-methylsulfonylanilino)acetamide
CAS 6467-37-4C22H26N4O5S
2-(2,4-Dimethoxy-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide chemical structure, C22H26N4O6S, CAS 428478-56-2
2-(2,4-Dimethoxy-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide
CAS 428478-56-2C22H26N4O6S
2-(2,3-Dimethyl-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide chemical structure, C22H26N4O4S, CAS 432511-74-5
2-(2,3-Dimethyl-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide
CAS 432511-74-5C22H26N4O4S
2-(3-Chloro-4-methyl-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide chemical structure, C21H23ClN4O4S, CAS 428448-99-1
2-(3-Chloro-4-methyl-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide
CAS 428448-99-1C21H23ClN4O4S
N~2~-(3-chloro-2-methylphenyl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N~2~-(methylsulfonyl)glycinamide chemical structure, C21H23ClN4O4S, CAS 333741-53-0
N~2~-(3-chloro-2-methylphenyl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N~2~-(methylsulfonyl)glycinamide
CAS 333741-53-0C21H23ClN4O4S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N~2~-(2,4-dimethylphenyl)-N~2~-(methylsulfonyl)glycinamide chemical structure, C22H26N4O4S, CAS 428495-82-3
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N~2~-(2,4-dimethylphenyl)-N~2~-(methylsulfonyl)glycinamide
CAS 428495-82-3C22H26N4O4S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N~2~-(4-methylphenyl)-N~2~-(methylsulfonyl)glycinamide chemical structure, C21H24N4O4S, CAS 331638-38-1
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N~2~-(4-methylphenyl)-N~2~-(methylsulfonyl)glycinamide
CAS 331638-38-1C21H24N4O4S
2-(2,5-Dichloro-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide chemical structure, C20H20Cl2N4O4S, CAS 535962-36-8
2-(2,5-Dichloro-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide
CAS 535962-36-8C20H20Cl2N4O4S
2-(2,3-Dichloro-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide chemical structure, C20H20Cl2N4O4S, CAS 432016-37-0
2-(2,3-Dichloro-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide
CAS 432016-37-0C20H20Cl2N4O4S
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(3-methyl-N-methylsulfonylanilino)acetamide chemical structure, C21H24N4O4S, CAS 426227-84-1
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(3-methyl-N-methylsulfonylanilino)acetamide
CAS 426227-84-1C21H24N4O4S
2-(3-Chloro-4-methoxy-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide chemical structure, C21H23ClN4O5S, CAS 428449-83-6
2-(3-Chloro-4-methoxy-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)acetamide
CAS 428449-83-6C21H23ClN4O5S
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(N-methylsulfonylanilino)propanamide chemical structure, C21H24N4O4S, CAS 474006-42-3
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(N-methylsulfonylanilino)propanamide
CAS 474006-42-3C21H24N4O4S
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(4-ethoxy-N-methylsulfonylanilino)propanamide chemical structure, C23H28N4O5S, CAS 474084-61-2
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(4-ethoxy-N-methylsulfonylanilino)propanamide
CAS 474084-61-2C23H28N4O5S
2-(4-Chloro-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)propanamide chemical structure, C21H23ClN4O4S, CAS 1008667-21-7
2-(4-Chloro-N-methylsulfonylanilino)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)propanamide
CAS 1008667-21-7C21H23ClN4O4S
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(2-ethyl-N-methylsulfonylanilino)acetamide chemical structure, C22H26N4O4S, CAS 428457-16-3
N-(1,5-Dimethyl-3-oxo-2-phenylpyrazol-4-yl)-2-(2-ethyl-N-methylsulfonylanilino)acetamide
CAS 428457-16-3C22H26N4O4S
N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2-[(2,5-dimethylphenyl)(methylsulfonyl)amino]acetamide chemical structure, C22H26N4O4S, CAS 335394-28-0
N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2-[(2,5-dimethylphenyl)(methylsulfonyl)amino]acetamide
CAS 335394-28-0C22H26N4O4S
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-[(methylsulfonyl)(phenyl)amino]butanamide chemical structure, C22H26N4O4S, CAS 1094384-35-6
N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-2-[(methylsulfonyl)(phenyl)amino]butanamide
CAS 1094384-35-6C22H26N4O4S