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Murcko scaffold

Ring system with 3 rings and 22 atoms

211 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
211
With full pages
111
Scaffold SMILES

O=C(CSc1nnc(-c2ccccn2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(-c2ccccn2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 211 chemicals

2-((4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-fluorophenyl)acetamide chemical structure, C15H13FN6OS, CAS 677780-09-5
2-((4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-fluorophenyl)acetamide
CAS 677780-09-5C15H13FN6OS
2-(4-Methyl-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))-N-(4-methylphenyl)acetamide chemical structure, C17H17N5OS, CAS 840498-22-8
2-(4-Methyl-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))-N-(4-methylphenyl)acetamide
CAS 840498-22-8C17H17N5OS
2-((4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2,4-dimethoxyphenyl)acetamide chemical structure, C17H18N6O3S, CAS 680593-45-7
2-((4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2,4-dimethoxyphenyl)acetamide
CAS 680593-45-7C17H18N6O3S
2-{[4-Allyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-methoxyphenyl)acetamide chemical structure, C19H19N5O2S, CAS 578003-91-5
2-{[4-Allyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2-methoxyphenyl)acetamide
CAS 578003-91-5C19H19N5O2S
2-((4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-ethoxyphenyl)acetamide chemical structure, C17H18N6O2S, CAS 577984-76-0
2-((4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-ethoxyphenyl)acetamide
CAS 577984-76-0C17H18N6O2S
2-{[4-Methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-[4-(propan-2-yl)phenyl]acetamide chemical structure, C19H21N5OS, CAS 578753-15-8
2-{[4-Methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-[4-(propan-2-yl)phenyl]acetamide
CAS 578753-15-8C19H21N5OS
2-((4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-methoxyphenyl)acetamide chemical structure, C16H16N6O2S, CAS 575463-03-5
2-((4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-methoxyphenyl)acetamide
CAS 575463-03-5C16H16N6O2S
N-(5-(Acetylamino)-2-methoxyphenyl)-2-((4-allyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)acetamide chemical structure, C21H22N6O3S, CAS 577789-17-4
N-(5-(Acetylamino)-2-methoxyphenyl)-2-((4-allyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)acetamide
CAS 577789-17-4C21H22N6O3S
2-(4-Amino-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))-N-(3-chloro-4-methoxyphenyl) acetamide chemical structure, C16H15ClN6O2S, CAS 579440-30-5
2-(4-Amino-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))-N-(3-chloro-4-methoxyphenyl) acetamide
CAS 579440-30-5C16H15ClN6O2S
N-[5-(Acetylamino)-2-methoxyphenyl]-2-(4-methyl-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))acetamide chemical structure, C19H20N6O3S, CAS 586995-25-7
N-[5-(Acetylamino)-2-methoxyphenyl]-2-(4-methyl-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))acetamide
CAS 586995-25-7C19H20N6O3S
N-(4-Fluorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H14FN5OS, CAS 678555-92-5
N-(4-Fluorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 678555-92-5C16H14FN5OS
2-((4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-fluorophenyl)acetamide chemical structure, C15H13FN6OS, CAS 677345-23-2
2-((4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-fluorophenyl)acetamide
CAS 677345-23-2C15H13FN6OS
N-(3-Methylphenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C17H17N5OS, CAS 842970-13-2
N-(3-Methylphenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 842970-13-2C17H17N5OS
2-(4-Amino-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))-N-(3-fluorophenyl)acetamide chemical structure, C15H13FN6OS, CAS 577766-71-3
2-(4-Amino-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))-N-(3-fluorophenyl)acetamide
CAS 577766-71-3C15H13FN6OS
N-(3-Fluorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H14FN5OS, CAS 578718-41-9
N-(3-Fluorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 578718-41-9C16H14FN5OS
N-(2-Fluorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H14FN5OS, CAS 579440-09-8
N-(2-Fluorophenyl)-2-{[4-methyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 579440-09-8C16H14FN5OS
N-(4-Methoxyphenyl)-2-[[4-propyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]acetamide chemical structure, C19H21N5O2S, CAS 626210-35-3
N-(4-Methoxyphenyl)-2-[[4-propyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]acetamide
CAS 626210-35-3C19H21N5O2S
2-{[4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(3,5-dimethoxyphenyl)acetamide chemical structure, C17H18N6O3S, CAS 575459-92-6
2-{[4-Amino-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(3,5-dimethoxyphenyl)acetamide
CAS 575459-92-6C17H18N6O3S
2-(4-Amino-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))-N-(2,4-difluorophenyl)acetam ide chemical structure, C15H12F2N6OS, CAS 677331-36-1
2-(4-Amino-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))-N-(2,4-difluorophenyl)acetam ide
CAS 677331-36-1C15H12F2N6OS
2-(4-Amino-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))-N-(2,5-dichlorophenyl)acetam ide chemical structure, C15H12Cl2N6OS, CAS 677731-69-0
2-(4-Amino-5-(2-pyridyl)(1,2,4-triazol-3-ylthio))-N-(2,5-dichlorophenyl)acetam ide
CAS 677731-69-0C15H12Cl2N6OS
N-[4-(Acetylamino)phenyl]-2-{[4-ethyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C19H20N6O2S, CAS 578720-61-3
N-[4-(Acetylamino)phenyl]-2-{[4-ethyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 578720-61-3C19H20N6O2S
N-(5-(Acetylamino)-2-methoxyphenyl)-2-((4-ethyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)acetamide chemical structure, C20H22N6O3S, CAS 578735-59-8
N-(5-(Acetylamino)-2-methoxyphenyl)-2-((4-ethyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)acetamide
CAS 578735-59-8C20H22N6O3S
2-{[4-Allyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2,4,6-tribromophenyl)acetamide chemical structure, C18H14Br3N5OS, CAS 618880-30-1
2-{[4-Allyl-5-(2-pyridinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2,4,6-tribromophenyl)acetamide
CAS 618880-30-1C18H14Br3N5OS
2-[(4-Amino-5-pyridin-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-chloro-5-(trifluoromethyl)phenyl]acetamide chemical structure, C16H12ClF3N6OS, CAS 840513-20-4
2-[(4-Amino-5-pyridin-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[2-chloro-5-(trifluoromethyl)phenyl]acetamide
CAS 840513-20-4C16H12ClF3N6OS