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Murcko scaffold

N-Phenyl-2-((3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)thio)acetamide scaffold

255 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
255
With full pages
79
Scaffold SMILES

O=C(CSc1nnc(-c2cccnc2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N-Phenyl-2-((3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)thio)acetamide page
Murcko scaffold O=C(CSc1nnc(-c2cccnc2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 255 chemicals

N-(2-Fluorophenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H16FN5OS, CAS 442631-12-1
N-(2-Fluorophenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 442631-12-1C18H16FN5OS
N-(4-Fluorophenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H16FN5OS, CAS 442632-54-4
N-(4-Fluorophenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 442632-54-4C18H16FN5OS
N-[5-(Acetylamino)-2-methoxyphenyl]-2-(4-methyl-5-(3-pyridyl)(1,2,4-triazol-3-ylthio))acetamide chemical structure, C19H20N6O3S, CAS 573695-90-6
N-[5-(Acetylamino)-2-methoxyphenyl]-2-(4-methyl-5-(3-pyridyl)(1,2,4-triazol-3-ylthio))acetamide
CAS 573695-90-6C19H20N6O3S
N-(5-Acetamido-2-methoxyphenyl)-2-[(4-prop-2-enyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C21H22N6O3S, CAS 578699-53-3
N-(5-Acetamido-2-methoxyphenyl)-2-[(4-prop-2-enyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
CAS 578699-53-3C21H22N6O3S
2-[(4-Amino-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2,4-difluorophenyl)acetamide chemical structure, C15H12F2N6OS, CAS 587011-62-9
2-[(4-Amino-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2,4-difluorophenyl)acetamide
CAS 587011-62-9C15H12F2N6OS
N-(2-Fluorophenyl)-2-{[4-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H14FN5OS, CAS 626204-93-1
N-(2-Fluorophenyl)-2-{[4-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 626204-93-1C16H14FN5OS
N-(3-Fluorophenyl)-2-{[4-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H14FN5OS, CAS 557065-81-3
N-(3-Fluorophenyl)-2-{[4-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 557065-81-3C16H14FN5OS
N-(4-Fluorophenyl)-2-{[4-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H14FN5OS, CAS 483327-10-2
N-(4-Fluorophenyl)-2-{[4-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 483327-10-2C16H14FN5OS
N-Phenyl-2-((3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)thio)acetamide chemical structure, C15H13N5OS, CAS 332157-94-5
N-Phenyl-2-((3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)thio)acetamide
CAS 332157-94-5C15H13N5OS
N-(3-Chlorophenyl)-2-((3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)thio)acetamide chemical structure, C15H12ClN5OS, CAS 332157-99-0
N-(3-Chlorophenyl)-2-((3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)thio)acetamide
CAS 332157-99-0C15H12ClN5OS
2-(4-Methyl-5-(3-pyridyl)(1,2,4-triazol-3-ylthio))-N-(3-methylphenyl)acetamide chemical structure, C17H17N5OS, CAS 338427-67-1
2-(4-Methyl-5-(3-pyridyl)(1,2,4-triazol-3-ylthio))-N-(3-methylphenyl)acetamide
CAS 338427-67-1C17H17N5OS
2-(4-Methyl-5-(3-pyridyl)(1,2,4-triazol-3-ylthio))-N-(4-methylphenyl)acetamide chemical structure, C17H17N5OS, CAS 482637-99-0
2-(4-Methyl-5-(3-pyridyl)(1,2,4-triazol-3-ylthio))-N-(4-methylphenyl)acetamide
CAS 482637-99-0C17H17N5OS
2-((4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-fluorophenyl)acetamide chemical structure, C15H13FN6OS, CAS 723316-26-5
2-((4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-fluorophenyl)acetamide
CAS 723316-26-5C15H13FN6OS
2-((4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-fluorophenyl)acetamide chemical structure, C15H13FN6OS, CAS 680982-73-4
2-((4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-fluorophenyl)acetamide
CAS 680982-73-4C15H13FN6OS
2-((4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3-fluorophenyl)acetamide chemical structure, C15H13FN6OS, CAS 578735-96-3
2-((4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3-fluorophenyl)acetamide
CAS 578735-96-3C15H13FN6OS
2-((4-Ethyl-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-N-(3-(trifluoromethyl)phenyl)acetamide chemical structure, C18H16F3N5OS, CAS 333331-34-3
2-((4-Ethyl-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-N-(3-(trifluoromethyl)phenyl)acetamide
CAS 333331-34-3C18H16F3N5OS
N-(2,4-Dimethoxyphenyl)-2-[(4-methyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide chemical structure, C18H19N5O3S, CAS 483308-28-7
N-(2,4-Dimethoxyphenyl)-2-[(4-methyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]acetamide
CAS 483308-28-7C18H19N5O3S
N-(3-Fluoro-4-methylphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C19H18FN5OS, CAS 442633-64-9
N-(3-Fluoro-4-methylphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 442633-64-9C19H18FN5OS
N-(3-Chloro-4-methoxyphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C19H18ClN5O2S, CAS 442665-50-1
N-(3-Chloro-4-methoxyphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 442665-50-1C19H18ClN5O2S
N-(3-Bromophenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H16BrN5OS, CAS 442666-16-2
N-(3-Bromophenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 442666-16-2C18H16BrN5OS
N-(3-Chloro-4-fluorophenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H15ClFN5OS, CAS 442664-16-6
N-(3-Chloro-4-fluorophenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 442664-16-6C18H15ClFN5OS
2-((4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-methoxy-5-methylphenyl)acetamide chemical structure, C17H18N6O2S, CAS 578720-32-8
2-((4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(2-methoxy-5-methylphenyl)acetamide
CAS 578720-32-8C17H18N6O2S
2-(4-Amino-5-(3-pyridyl)(1,2,4-triazol-3-ylthio))-N-(3,5-dimethoxyphenyl)aceta mide chemical structure, C17H18N6O3S, CAS 710988-15-1
2-(4-Amino-5-(3-pyridyl)(1,2,4-triazol-3-ylthio))-N-(3,5-dimethoxyphenyl)aceta mide
CAS 710988-15-1C17H18N6O3S
N-(3,5-DI-Meo-PH)-2-((4-ET-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C19H21N5O3S, CAS 557065-59-5
N-(3,5-DI-Meo-PH)-2-((4-ET-5-(3-pyridinyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 557065-59-5C19H21N5O3S