Murcko scaffold
Ring system with 3 rings and 22 atoms
249 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 22
- Chemicals
- 249
- With full pages
- 110
Scaffold SMILES
O=C(NN=Cc1ccccc1)c1cc(-c2ccccc2)n[nH]1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
![Murcko scaffold O=C(NN=Cc1ccccc1)c1cc(-c2ccccc2)n[nH]1](/scaffold/HSDVCEWEQSYSJL-UHFFFAOYSA-N/structure.svg)
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 249 chemicals
N'-(4-Hydroxybenzylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
C18H16N4O3
![5-Phenyl-1H-pyrazole-3-carboxylic acid 2-[(5-bromo-2-hydroxy-3-methylphenyl)methylene]hydrazide chemical structure, C18H15BrN4O2, CAS 899718-45-7](/s/INWWQXMBMTURAV-UHFFFAOYSA-N.svg)
5-Phenyl-1H-pyrazole-3-carboxylic acid 2-[(5-bromo-2-hydroxy-3-methylphenyl)methylene]hydrazide
CAS 899718-45-7C18H15BrN4O2
![N-[(5-Bromo-2-hydroxyphenyl)methylideneamino]-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide chemical structure, C17H12BrFN4O2, CAS 6750-16-9](/s/LCSVTIBFCGBZTG-UHFFFAOYSA-N.svg)
N-[(5-Bromo-2-hydroxyphenyl)methylideneamino]-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide
CAS 6750-16-9C17H12BrFN4O2
![3-(4-Fluorophenyl)-N-[(3,4,5-trimethoxyphenyl)methylideneamino]-1H-pyrazole-5-carboxamide chemical structure, C20H19FN4O4, CAS 6750-17-0](/s/AAGCIVLKJFVVDH-UHFFFAOYSA-N.svg)
3-(4-Fluorophenyl)-N-[(3,4,5-trimethoxyphenyl)methylideneamino]-1H-pyrazole-5-carboxamide
CAS 6750-17-0C20H19FN4O4
N'-((1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
CAS 307321-52-4C21H22N4O4
![N-{[4-(Diethylamino)phenyl]methylidene}-5-(4-methylphenyl)-1H-pyrazole-3-carbohydrazonic acid chemical structure, C22H25N5O, CAS 5670-08-6](/s/SQOLKYRLPASAFP-UHFFFAOYSA-N.svg)
N-{[4-(Diethylamino)phenyl]methylidene}-5-(4-methylphenyl)-1H-pyrazole-3-carbohydrazonic acid
CAS 5670-08-6C22H25N5O
![3-(3,4-Dichlorophenyl)-N-[(4-hydroxyphenyl)methylideneamino]-1H-pyrazole-5-carboxamide chemical structure, C17H12Cl2N4O2](/s/UKVPZAGJPSJWJQ-UHFFFAOYSA-N.svg)
3-(3,4-Dichlorophenyl)-N-[(4-hydroxyphenyl)methylideneamino]-1H-pyrazole-5-carboxamide
C17H12Cl2N4O2
![5-(3,4-Dimethylphenyl)-1H-pyrazole-3-carboxylic acid 2-[(4-ethylphenyl)methylene]hydrazide chemical structure, C21H22N4O, CAS 1038563-15-3](/s/AJESBHKNZNVEGO-UHFFFAOYSA-N.svg)
5-(3,4-Dimethylphenyl)-1H-pyrazole-3-carboxylic acid 2-[(4-ethylphenyl)methylene]hydrazide
CAS 1038563-15-3C21H22N4O
![5-(4-Methylphenyl)-1H-pyrazole-3-carboxylic acid 2-[(4-chloro-3-nitrophenyl)methylene]hydrazide chemical structure, C18H14ClN5O3, CAS 402482-15-9](/s/IHYRMSALQLHLKE-UHFFFAOYSA-N.svg)
5-(4-Methylphenyl)-1H-pyrazole-3-carboxylic acid 2-[(4-chloro-3-nitrophenyl)methylene]hydrazide
CAS 402482-15-9C18H14ClN5O3
![5-(4-Chlorophenyl)-1H-pyrazole-3-carboxylic acid 2-[(2-chloro-5-nitrophenyl)methylene]hydrazide chemical structure, C17H11Cl2N5O3, CAS 1038771-19-5](/s/WFSNWKVEYYDEAU-UHFFFAOYSA-N.svg)
5-(4-Chlorophenyl)-1H-pyrazole-3-carboxylic acid 2-[(2-chloro-5-nitrophenyl)methylene]hydrazide
CAS 1038771-19-5C17H11Cl2N5O3
![5-(3,4-Dimethylphenyl)-1H-pyrazole-3-carboxylic acid 2-[1-(4-fluorophenyl)ethylidene]hydrazide chemical structure, C20H19FN4O, CAS 1039053-19-4](/s/OVBRNOUXADGFPN-UHFFFAOYSA-N.svg)
5-(3,4-Dimethylphenyl)-1H-pyrazole-3-carboxylic acid 2-[1-(4-fluorophenyl)ethylidene]hydrazide
CAS 1039053-19-4C20H19FN4O
![[2-Methoxy-4-[[[3-(4-methoxyphenyl)-1H-pyrazole-5-carbonyl]hydrazinylidene]methyl]phenyl] acetate chemical structure, C21H20N4O5, CAS 5307-16-4](/s/VFGRIXAQWXUUMS-UHFFFAOYSA-N.svg)
[2-Methoxy-4-[[[3-(4-methoxyphenyl)-1H-pyrazole-5-carbonyl]hydrazinylidene]methyl]phenyl] acetate
CAS 5307-16-4C21H20N4O5
![N-[(4-Ethylphenyl)methylideneamino]-3-(4-octoxyphenyl)-1H-pyrazole-5-carboxamide chemical structure, C27H34N4O2, CAS 6644-69-5](/s/LOYPQTFRHDMTGK-UHFFFAOYSA-N.svg)
N-[(4-Ethylphenyl)methylideneamino]-3-(4-octoxyphenyl)-1H-pyrazole-5-carboxamide
CAS 6644-69-5C27H34N4O2
![N-[(4-Chlorophenyl)methylideneamino]-1-methyl-5-phenyl-pyrazole-3-carboxamide chemical structure, C18H15ClN4O, CAS 5302-17-0](/s/CXWURHKSKYWVBQ-UDWIEESQSA-N.svg)
N-[(4-Chlorophenyl)methylideneamino]-1-methyl-5-phenyl-pyrazole-3-carboxamide
CAS 5302-17-0C18H15ClN4O
(E)-N'-(3-Hydroxybenzylidene)-3-phenyl-1H-pyrazole-5-carbohydrazide
CAS 1285495-93-3C17H14N4O2
![N-[(E)-[4-(Diethylamino)phenyl]methylideneamino]-3-phenyl-1H-pyrazole-5-carboxamide chemical structure, C21H23N5O, CAS 5785-85-3](/s/JKIYFKGITQMOOR-PXLXIMEGSA-N.svg)
N-[(E)-[4-(Diethylamino)phenyl]methylideneamino]-3-phenyl-1H-pyrazole-5-carboxamide
CAS 5785-85-3C21H23N5O
![3-(4-Ethoxyphenyl)-N'-[(1E)-1-phenylethylidene]-1H-pyrazole-5-carbohydrazide chemical structure, C20H20N4O2, CAS 5786-16-3](/s/KPELCPDXNUGKQZ-KGENOOAVSA-N.svg)
3-(4-Ethoxyphenyl)-N'-[(1E)-1-phenylethylidene]-1H-pyrazole-5-carbohydrazide
CAS 5786-16-3C20H20N4O2
![N'-[(1E)-1-(4-Methoxyphenyl)ethylidene]-3-phenyl-1H-pyrazole-5-carbohydrazide chemical structure, C19H18N4O2, CAS 1284266-34-7](/s/LVFWIUBMGMTRED-DEDYPNTBSA-N.svg)
N'-[(1E)-1-(4-Methoxyphenyl)ethylidene]-3-phenyl-1H-pyrazole-5-carbohydrazide
CAS 1284266-34-7C19H18N4O2
![N-[(E)-1-(3,4-Dimethoxyphenyl)ethylideneamino]-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide chemical structure, C21H22N4O4, CAS 1259484-97-3](/s/GMFUWEBOUKIKRP-LPYMAVHISA-N.svg)
N-[(E)-1-(3,4-Dimethoxyphenyl)ethylideneamino]-3-(4-methoxyphenyl)-1H-pyrazole-5-carboxamide
CAS 1259484-97-3C21H22N4O4
![N'-[(E)-(4-Chlorophenyl)methylidene]-3-(4-ethoxyphenyl)-1H-pyrazole-5-carbohydrazide chemical structure, C19H17ClN4O2, CAS 5788-48-7](/s/VINUPBANSWZAAU-CIAFOILYSA-N.svg)
N'-[(E)-(4-Chlorophenyl)methylidene]-3-(4-ethoxyphenyl)-1H-pyrazole-5-carbohydrazide
CAS 5788-48-7C19H17ClN4O2
(E)-3-(4-Chlorophenyl)-N'-(4-nitrobenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 1285496-67-4C17H12ClN5O3
(E)-3-(4-Chlorophenyl)-N'-(4-isopropylbenzylidene)-1H-pyrazole-5-carbohydrazide
CAS 306754-19-8C20H19ClN4O
(E)-4-Methyl-N'-(3-nitrobenzylidene)-3-phenyl-1H-pyrazole-5-carbohydrazide
CAS 306758-96-3C18H15N5O3
![N'-[(1E)-1-(4-Methoxyphenyl)ethylidene]-4-methyl-3-phenyl-1H-pyrazole-5-carbohydrazide chemical structure, C20H20N4O2, CAS 1284267-38-4](/s/TXDZDXYHKPJNHV-KGENOOAVSA-N.svg)
N'-[(1E)-1-(4-Methoxyphenyl)ethylidene]-4-methyl-3-phenyl-1H-pyrazole-5-carbohydrazide
CAS 1284267-38-4C20H20N4O2
- (Z)-N'-Benzylidene-3-(4-ethylphenyl)-1H-pyrazole-5-carbohydrazide387832-69-1C19H18N4O
- N'-[(1E)-1-(4-Bromophenyl)ethylidene]-3-(4-ethoxyphenyl)-1H-pyrazole-5-carbohydrazide1285536-66-4C20H19BrN4O2
- (E)-N'-(1-(4-Bromophenyl)ethylidene)-4-methyl-3-phenyl-1H-pyrazole-5-carbohydrazide1285532-39-9C19H17BrN4O
- 3-(3-Ethoxyphenyl)N'-(1-(4-methylphenyl)ethylidene)-1H-pyrazole-5-carbohydrazide302917-95-9C21H22N4O2
- N'-(1-(4-Bromophenyl)ethylidene)-3-(3-ethoxyphenyl)-1H-pyrazole-5-carbohydrazide303107-65-5C20H19BrN4O2
- N-[(Z)-[4-(Diethylamino)phenyl]methylideneamino]-3-(4-fluorophenyl)-1H-pyrazole-5-carboxamide403649-77-4C21H22FN5O
- 3-(2-Ethoxyphenyl)-N'-(1-(3-HO-PH)ethylidene)-1H-pyrazole-5-carbohydrazide402482-30-8C20H20N4O3
- N'-(1-(4-Chlorophenyl)ethylidene)-3-(4-ethylphenyl)-1H-pyrazole-5-carbohydrazide700352-66-5C20H19ClN4O
- (Z)-N'-(4-Bromobenzylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide305355-48-0C18H15BrN4O2
- (Z)-3-(4-Isopropoxy-3-methoxyphenyl)-N'-(4-methoxybenzylidene)-1H-pyrazole-5-carbohydrazide1285531-38-5C22H24N4O4
- (E)-N'-(1-(3-Hydroxyphenyl)ethylidene)-5-(4-isobutylphenyl)-1H-pyrazole-3-carbohydrazide1310364-94-3C22H24N4O2
- (Z)-N'-(2,6-Dichlorobenzylidene)-3-(4-fluorophenyl)-1H-pyrazole-5-carbohydrazide1284268-53-6C17H11Cl2FN4O
- (Z)-N'-(4-Chlorobenzylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide305355-75-3C18H15ClN4O2
- (Z)-3-(2,4-Dichlorophenyl)-N'-(1-(4-nitrophenyl)ethylidene)-1H-pyrazole-5-carbohydrazide1284276-97-6C18H13Cl2N5O3
- 3-(4-Methylphenyl)-N'-[(1E)-1-(3-nitrophenyl)ethylidene]-1H-pyrazole-5-carbohydrazide1309680-37-2C19H17N5O3
- (Z)-3-(4-Chlorophenyl)-N'-(1-(3-hydroxyphenyl)ethylidene)-1H-pyrazole-5-carbohydrazide1285613-51-5C18H15ClN4O2
- 3-(4-Isobutoxyphenyl)-N'-(1-(4-nitro-PH)ethylidene)-1H-pyrazole-5-carbohydrazide634898-56-9C22H23N5O4
- 3-(4-Isobutoxyphenyl)-N'-(1-(3-nitro-PH)ethylidene)-1H-pyrazole-5-carbohydrazide634898-57-0C22H23N5O4
- (Z)-N'-(2-Chlorobenzylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide305355-63-9C18H15ClN4O2
- (Z)-N'-(2-Chloro-6-fluorobenzylidene)-3-(4-fluorophenyl)-1H-pyrazole-5-carbohydrazide403649-59-2C17H11ClF2N4O
- (E)-N'-(4-(Diethylamino)benzylidene)-3-(p-tolyl)-1H-pyrazole-5-carbohydrazide1285533-44-9C22H25N5O
- (Z)-N'-(1-(4-Methoxyphenyl)ethylidene)-3-(4-propoxyphenyl)-1H-pyrazole-5-carbohydrazide1285500-81-3C22H24N4O3
- N'-(4-(Diethylamino)benzylidene)-3-(4-meo-PH)-4-ME-1H-pyrazole-5-carbohydrazide303104-07-6C23H27N5O2
- (Z)-3-(3-Nitrophenyl)-N'-(1-(4-nitrophenyl)ethylidene)-1H-pyrazole-5-carbohydrazide1284268-51-4C18H14N6O5
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![Scaffold O=C(CSc1nnc(-c2ccccn2)[nH]1)Nc1ccccc1](/scaffold/RPGQONZTKJZFKA-UHFFFAOYSA-N/structure.svg)
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