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Murcko scaffold

Ring system with 3 rings and 22 atoms

72 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 72
With full pages: 14

Scaffold SMILES

O=C(CSc1nnc(C2CCCCC2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nnc(C2CCCCC2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 72 chemicals

2-(4-Amino-5-cyclohexyl(1,2,4-triazol-3-ylthio))-N-(3,4-difluorophenyl)acetami de chemical structure, C16H19F2N5OS, CAS 677011-66-4

2-(4-Amino-5-cyclohexyl(1,2,4-triazol-3-ylthio))-N-(3,4-difluorophenyl)acetami de

CAS 677011-66-4C₁₆H₁₉F₂N₅OS

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-fluorophenyl)acetamide chemical structure, C16H20FN5OS, CAS 677331-79-2

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-fluorophenyl)acetamide

CAS 677331-79-2C₁₆H₂₀FN₅OS

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(3-fluorophenyl)acetamide chemical structure, C16H20FN5OS, CAS 573941-19-2

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(3-fluorophenyl)acetamide

CAS 573941-19-2C₁₆H₂₀FN₅OS

2-[(4-Amino-5-cyclohexyl-1,2,4-triazol-3-yl)thio]-N-(3-fluoro-4-methylphenyl)acetamide chemical structure, C17H22FN5OS, CAS 577696-81-2

2-[(4-Amino-5-cyclohexyl-1,2,4-triazol-3-yl)thio]-N-(3-fluoro-4-methylphenyl)acetamide

CAS 577696-81-2C₁₇H₂₂FN₅OS

2-(4-Amino-5-cyclohexyl(1,2,4-triazol-3-ylthio))-N-(2,4-difluorophenyl)acetami de chemical structure, C16H19F2N5OS, CAS 578701-61-8

2-(4-Amino-5-cyclohexyl(1,2,4-triazol-3-ylthio))-N-(2,4-difluorophenyl)acetami de

CAS 578701-61-8C₁₆H₁₉F₂N₅OS

2-((5-Cyclohexyl-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N-phenylacetamide chemical structure, C18H24N4OS, CAS 482650-84-0

2-((5-Cyclohexyl-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N-phenylacetamide

CAS 482650-84-0C₁₈H₂₄N₄OS

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(m-tolyl)acetamide chemical structure, C17H23N5OS, CAS 843633-88-5

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(m-tolyl)acetamide

CAS 843633-88-5C₁₇H₂₃N₅OS

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(p-tolyl)acetamide chemical structure, C17H23N5OS, CAS 578746-81-3

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(p-tolyl)acetamide

CAS 578746-81-3C₁₇H₂₃N₅OS

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(2-fluorophenyl)acetamide chemical structure, C16H20FN5OS, CAS 577699-75-3

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(2-fluorophenyl)acetamide

CAS 577699-75-3C₁₆H₂₀FN₅OS

N-(4-Chlorophenyl)-2-((5-cyclohexyl-4-ethyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C18H23ClN4OS, CAS 482650-85-1

N-(4-Chlorophenyl)-2-((5-cyclohexyl-4-ethyl-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 482650-85-1C₁₈H₂₃ClN₄OS

2-((5-Cyclohexyl-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N-(3,4-dichlorophenyl)acetamide chemical structure, C18H22Cl2N4OS, CAS 443742-90-3

2-((5-Cyclohexyl-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N-(3,4-dichlorophenyl)acetamide

CAS 443742-90-3C₁₈H₂₂Cl₂N₄OS

2-((5-Cyclohexyl-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N-(p-tolyl)acetamide chemical structure, C19H26N4OS, CAS 482651-08-1

2-((5-Cyclohexyl-4-ethyl-4H-1,2,4-triazol-3-yl)thio)-N-(p-tolyl)acetamide

CAS 482651-08-1C₁₉H₂₆N₄OS

N-(3-Chloro-4-methylphenyl)-2-((5-cyclohexyl-4-ethyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C19H25ClN4OS, CAS 482651-09-2

N-(3-Chloro-4-methylphenyl)-2-((5-cyclohexyl-4-ethyl-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 482651-09-2C₁₉H₂₅ClN₄OS

2-[(4-Amino-5-cyclohexyl-1,2,4-triazol-3-yl)sulfanyl]-N-(3,5-dimethoxyphenyl)acetamide chemical structure, C18H25N5O3S, CAS 678145-80-7

2-[(4-Amino-5-cyclohexyl-1,2,4-triazol-3-yl)sulfanyl]-N-(3,5-dimethoxyphenyl)acetamide

CAS 678145-80-7C₁₈H₂₅N₅O₃S

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(2-chloro-5-(trifluoromethyl)phenyl)acetamide chemical structure, C17H19ClF3N5OS, CAS 575471-58-8

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(2-chloro-5-(trifluoromethyl)phenyl)acetamide

CAS 575471-58-8C₁₇H₁₉ClF₃N₅OS

N-(4-Acetamidophenyl)-2-((4-amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C18H24N6O2S, CAS 678158-27-5

N-(4-Acetamidophenyl)-2-((4-amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)acetamide

CAS 678158-27-5C₁₈H₂₄N₆O₂S

N-[5-(Acetylamino)-2-methoxyphenyl]-2-(4-amino-5-cyclohexyl(1,2,4-triazol-3-yl thio))acetamide chemical structure, C19H26N6O3S, CAS 710988-30-0

N-[5-(Acetylamino)-2-methoxyphenyl]-2-(4-amino-5-cyclohexyl(1,2,4-triazol-3-yl thio))acetamide

CAS 710988-30-0C₁₉H₂₆N₆O₃S

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-chlorophenyl)acetamide chemical structure, C16H20ClN5OS, CAS 678541-31-6

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-chlorophenyl)acetamide

CAS 678541-31-6C₁₆H₂₀ClN₅OS

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(2-methoxyphenyl)acetamide chemical structure, C17H23N5O2S, CAS 840514-95-6

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(2-methoxyphenyl)acetamide

CAS 840514-95-6C₁₇H₂₃N₅O₂S

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(3-chlorophenyl)acetamide chemical structure, C16H20ClN5OS, CAS 575471-11-3

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(3-chlorophenyl)acetamide

CAS 575471-11-3C₁₆H₂₀ClN₅OS

2-[(4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-butylphenyl)acetamide chemical structure, C20H29N5OS, CAS 577694-50-9

2-[(4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-butylphenyl)acetamide

CAS 577694-50-9C₂₀H₂₉N₅OS

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-chloro-3-(trifluoromethyl)phenyl)acetamide chemical structure, C17H19ClF3N5OS, CAS 577697-49-5

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(4-chloro-3-(trifluoromethyl)phenyl)acetamide

CAS 577697-49-5C₁₇H₁₉ClF₃N₅OS

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(2,6-dimethylphenyl)acetamide chemical structure, C18H25N5OS, CAS 577698-70-5

2-((4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)thio)-N-(2,6-dimethylphenyl)acetamide

CAS 577698-70-5C₁₈H₂₅N₅OS

2-[(4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(propan-2-yl)phenyl]acetamide chemical structure, C19H27N5OS, CAS 585552-33-6

2-[(4-Amino-5-cyclohexyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-[4-(propan-2-yl)phenyl]acetamide

CAS 585552-33-6C₁₉H₂₇N₅OS