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Murcko scaffold

Ring system with 3 rings and 22 atoms

123 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
123
With full pages
56
Scaffold SMILES

O=C(CSc1nnc(-c2cnccn2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(-c2cnccn2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 123 chemicals

N-(2-Ethoxyphenyl)-2-((4-ET-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl)thio)acetamide chemical structure, C18H20N6O2S, CAS 618427-36-4
N-(2-Ethoxyphenyl)-2-((4-ET-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl)thio)acetamide
CAS 618427-36-4C18H20N6O2S
N-(2,5-Dimethylphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C19H20N6OS, CAS 840482-37-3
N-(2,5-Dimethylphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 840482-37-3C19H20N6OS
N-(3-Methylphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H18N6OS, CAS 843620-21-3
N-(3-Methylphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 843620-21-3C18H18N6OS
2-((4-Ethyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-N-(2-methoxyphenyl)acetamide chemical structure, C17H18N6O2S, CAS 578003-17-5
2-((4-Ethyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)-N-(2-methoxyphenyl)acetamide
CAS 578003-17-5C17H18N6O2S
N-(2-Ethoxyphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C17H18N6O2S, CAS 573971-47-8
N-(2-Ethoxyphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 573971-47-8C17H18N6O2S
N-(2,6-Dimethylphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C19H20N6OS, CAS 578003-85-7
N-(2,6-Dimethylphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 578003-85-7C19H20N6OS
N-(2,5-Dimethylphenyl)-2-{[4-ethyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H20N6OS, CAS 577963-14-5
N-(2,5-Dimethylphenyl)-2-{[4-ethyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 577963-14-5C18H20N6OS
N-(3,5-Dimethylphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C19H20N6OS, CAS 587002-47-9
N-(3,5-Dimethylphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 587002-47-9C19H20N6OS
N-(4-Methylphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H16N6OS, CAS 585550-49-8
N-(4-Methylphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 585550-49-8C16H16N6OS
N-(3-Methylphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H16N6OS, CAS 585554-14-9
N-(3-Methylphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 585554-14-9C16H16N6OS
N-(3-Fluorophenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C15H13FN6OS, CAS 738593-05-0
N-(3-Fluorophenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 738593-05-0C15H13FN6OS
N-(2-Fluorophenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C15H13FN6OS, CAS 587007-06-5
N-(2-Fluorophenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 587007-06-5C15H13FN6OS
2-{[4-Methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2,4,6-trimethylphenyl)acetamide chemical structure, C18H20N6OS, CAS 578000-30-3
2-{[4-Methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(2,4,6-trimethylphenyl)acetamide
CAS 578000-30-3C18H20N6OS
N-(3,4-Dimethylphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C17H18N6OS, CAS 720677-88-3
N-(3,4-Dimethylphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 720677-88-3C17H18N6OS
N-(3,5-Dimethylphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C17H18N6OS, CAS 720677-89-4
N-(3,5-Dimethylphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 720677-89-4C17H18N6OS
N-[4-(Dimethylamino)phenyl]-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C17H19N7OS, CAS 573950-04-6
N-[4-(Dimethylamino)phenyl]-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 573950-04-6C17H19N7OS
N-(2,4-Difluorophenyl)-2-{[4-ethyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H14F2N6OS, CAS 678190-65-3
N-(2,4-Difluorophenyl)-2-{[4-ethyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 678190-65-3C16H14F2N6OS
N-(3,5-Dichlorophenyl)-2-((4-ethyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)acetamide chemical structure, C16H14Cl2N6OS, CAS 618427-47-7
N-(3,5-Dichlorophenyl)-2-((4-ethyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl)sulfanyl)acetamide
CAS 618427-47-7C16H14Cl2N6OS
N-(3,4-Dimethylphenyl)-2-{[4-ethyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H20N6OS, CAS 573933-59-2
N-(3,4-Dimethylphenyl)-2-{[4-ethyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 573933-59-2C18H20N6OS
N-(3-Chloro-4-methoxyphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C16H15ClN6O2S, CAS 573934-90-4
N-(3-Chloro-4-methoxyphenyl)-2-{[4-methyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 573934-90-4C16H15ClN6O2S
N-(2-Ethoxyphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C19H20N6O2S, CAS 573935-26-9
N-(2-Ethoxyphenyl)-2-{[4-(prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 573935-26-9C19H20N6O2S
2-{[4-(Prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-sulfamoylphenyl)acetamide chemical structure, C17H17N7O3S2, CAS 573937-48-1
2-{[4-(Prop-2-en-1-yl)-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(4-sulfamoylphenyl)acetamide
CAS 573937-48-1C17H17N7O3S2
2-((4-Allyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3,5-bis(trifluoromethyl)phenyl)acetamide chemical structure, C19H14F6N6OS, CAS 573945-41-2
2-((4-Allyl-5-(pyrazin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3,5-bis(trifluoromethyl)phenyl)acetamide
CAS 573945-41-2C19H14F6N6OS
N-(4-Chloro-2-methoxy-5-methylphenyl)-2-{[4-ethyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide chemical structure, C18H19ClN6O2S, CAS 573945-54-7
N-(4-Chloro-2-methoxy-5-methylphenyl)-2-{[4-ethyl-5-(2-pyrazinyl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide
CAS 573945-54-7C18H19ClN6O2S