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Murcko scaffold

Ring system with 3 rings and 22 atoms

214 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
214
With full pages
52
Scaffold SMILES

O=C(C=Cc1ccc(-c2ccccc2)o1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccc(-c2ccccc2)o1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 214 chemicals

(Z)-2-Cyano-N-(2-hydroxyphenyl)-3-(5-phenylfuran-2-yl)acrylamide chemical structure, C20H14N2O3, CAS 300675-16-5
(Z)-2-Cyano-N-(2-hydroxyphenyl)-3-(5-phenylfuran-2-yl)acrylamide
CAS 300675-16-5C20H14N2O3
(E)-2-Cyano-N-phenyl-3-(5-phenylfuran-2-yl)acrylamide chemical structure, C20H14N2O2, CAS 304896-11-5
(E)-2-Cyano-N-phenyl-3-(5-phenylfuran-2-yl)acrylamide
CAS 304896-11-5C20H14N2O2
2-Cyano-N-(4-fluorophenyl)-3-(5-phenyl-2-furyl)acrylamide chemical structure, C20H13FN2O2, CAS 304896-13-7
2-Cyano-N-(4-fluorophenyl)-3-(5-phenyl-2-furyl)acrylamide
CAS 304896-13-7C20H13FN2O2
N-(3-Chlorophenyl)-2-cyano-3-(5-phenyl-2-furyl)acrylamide chemical structure, C20H13ClN2O2, CAS 304896-17-1
N-(3-Chlorophenyl)-2-cyano-3-(5-phenyl-2-furyl)acrylamide
CAS 304896-17-1C20H13ClN2O2
2-Cyano-N-(4-cyanophenyl)-3-(5-phenyl-2-furyl)acrylamide chemical structure, C21H13N3O2, CAS 304896-19-3
2-Cyano-N-(4-cyanophenyl)-3-(5-phenyl-2-furyl)acrylamide
CAS 304896-19-3C21H13N3O2
(2E)-2-Cyano-N-(2-methylphenyl)-3-(5-phenylfuran-2-yl)prop-2-enamide chemical structure, C21H16N2O2, CAS 301177-10-6
(2E)-2-Cyano-N-(2-methylphenyl)-3-(5-phenylfuran-2-yl)prop-2-enamide
CAS 301177-10-6C21H16N2O2
(E)-2-Cyano-3-(5-phenylfuran-2-yl)-N-(m-tolyl)acrylamide chemical structure, C21H16N2O2, CAS 301177-15-1
(E)-2-Cyano-3-(5-phenylfuran-2-yl)-N-(m-tolyl)acrylamide
CAS 301177-15-1C21H16N2O2
(E)-3-[5-(4-Chlorophenyl)furan-2-yl]-2-cyano-N-phenylprop-2-enamide chemical structure, C20H13ClN2O2, CAS 305863-20-1
(E)-3-[5-(4-Chlorophenyl)furan-2-yl]-2-cyano-N-phenylprop-2-enamide
CAS 305863-20-1C20H13ClN2O2
3-(5-(2-Chlorophenyl)-2-furyl)-N-(4-methylphenyl)-2-propenamide chemical structure, C20H16ClNO2, CAS 853348-47-7
3-(5-(2-Chlorophenyl)-2-furyl)-N-(4-methylphenyl)-2-propenamide
CAS 853348-47-7C20H16ClNO2
N-(4-Methylphenyl)-3-(5-(3-nitrophenyl)-2-furyl)-2-propenamide chemical structure, C20H16N2O4, CAS 853351-10-7
N-(4-Methylphenyl)-3-(5-(3-nitrophenyl)-2-furyl)-2-propenamide
CAS 853351-10-7C20H16N2O4
(E)-2-Cyano-3-[5-(2,4-dichlorophenyl)furan-2-yl]-N-phenylprop-2-enamide chemical structure, C20H12Cl2N2O2, CAS 314259-18-2
(E)-2-Cyano-3-[5-(2,4-dichlorophenyl)furan-2-yl]-N-phenylprop-2-enamide
CAS 314259-18-2C20H12Cl2N2O2
2-Cyano-3-[5-(3-nitro-phenyl)-furan-2-yl]-N-phenyl-acrylamide chemical structure, C20H13N3O4, CAS 313520-63-7
2-Cyano-3-[5-(3-nitro-phenyl)-furan-2-yl]-N-phenyl-acrylamide
CAS 313520-63-7C20H13N3O4
(E)-2-Cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(m-tolyl)acrylamide chemical structure, C21H14Cl2N2O2, CAS 301177-19-5
(E)-2-Cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(m-tolyl)acrylamide
CAS 301177-19-5C21H14Cl2N2O2
(2E)-2-Cyano-N-phenyl-3-[5-(4-sulfamoylphenyl)furan-2-yl]prop-2-enamide chemical structure, C20H15N3O4S, CAS 344949-67-3
(2E)-2-Cyano-N-phenyl-3-[5-(4-sulfamoylphenyl)furan-2-yl]prop-2-enamide
CAS 344949-67-3C20H15N3O4S
3-(5-{2-Cyano-2-[(2-methylphenyl)carbamoyl]eth-1-en-1-yl}furan-2-yl)-2-methylbenzoic acid chemical structure, C23H18N2O4, CAS 333442-79-8
3-(5-{2-Cyano-2-[(2-methylphenyl)carbamoyl]eth-1-en-1-yl}furan-2-yl)-2-methylbenzoic acid
CAS 333442-79-8C23H18N2O4
(E)-2-Cyano-3-(5-(3-nitrophenyl)furan-2-yl)-N-(3-(trifluoromethyl)phenyl)acrylamide chemical structure, C21H12F3N3O4, CAS 306321-19-7
(E)-2-Cyano-3-(5-(3-nitrophenyl)furan-2-yl)-N-(3-(trifluoromethyl)phenyl)acrylamide
CAS 306321-19-7C21H12F3N3O4
(E)-Methyl 2-(2-cyano-3-(5-(4-fluorophenyl)furan-2-yl)acrylamido)benzoate chemical structure, C22H15FN2O4, CAS 469872-86-4
(E)-Methyl 2-(2-cyano-3-(5-(4-fluorophenyl)furan-2-yl)acrylamido)benzoate
CAS 469872-86-4C22H15FN2O4
(E)-N-(4-Acetamidophenyl)-2-cyano-3-(5-(4-fluorophenyl)furan-2-yl)acrylamide chemical structure, C22H16FN3O3, CAS 469872-92-2
(E)-N-(4-Acetamidophenyl)-2-cyano-3-(5-(4-fluorophenyl)furan-2-yl)acrylamide
CAS 469872-92-2C22H16FN3O3
2-Cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide chemical structure, C23H19N3O4, CAS 5273-96-1
2-Cyano-3-[5-(2-nitrophenyl)furan-2-yl]-N-(2,4,6-trimethylphenyl)prop-2-enamide
CAS 5273-96-1C23H19N3O4
Ethyl 4-{5-[2-cyano-3-(2-methoxyanilino)-3-oxo-1-propenyl]-2-furyl}benzoate chemical structure, C24H20N2O5, CAS 313520-74-0
Ethyl 4-{5-[2-cyano-3-(2-methoxyanilino)-3-oxo-1-propenyl]-2-furyl}benzoate
CAS 313520-74-0C24H20N2O5
(E)-2-Cyano-N-(3-ethoxyphenyl)-3-[5-(2-nitrophenyl)furan-2-yl]prop-2-enamide chemical structure, C22H17N3O5, CAS 340310-92-1
(E)-2-Cyano-N-(3-ethoxyphenyl)-3-[5-(2-nitrophenyl)furan-2-yl]prop-2-enamide
CAS 340310-92-1C22H17N3O5
3-(5-(2-Chlorophenyl)-2-furyl)-N-(4-methoxyphenyl)-2-propenamide chemical structure, C20H16ClNO3, CAS 853348-49-9
3-(5-(2-Chlorophenyl)-2-furyl)-N-(4-methoxyphenyl)-2-propenamide
CAS 853348-49-9C20H16ClNO3
2-Cyano-3-[5-(4-methoxy-2-nitrophenyl)-2-furyl]-N-phenylacrylamide chemical structure, C21H15N3O5, CAS 5831-40-3
2-Cyano-3-[5-(4-methoxy-2-nitrophenyl)-2-furyl]-N-phenylacrylamide
CAS 5831-40-3C21H15N3O5
(E)-3-[5-(2-Chloro-5-nitrophenyl)furan-2-yl]-2-cyano-N-(4-methoxyphenyl)prop-2-enamide chemical structure, C21H14ClN3O5, CAS 5868-09-7
(E)-3-[5-(2-Chloro-5-nitrophenyl)furan-2-yl]-2-cyano-N-(4-methoxyphenyl)prop-2-enamide
CAS 5868-09-7C21H14ClN3O5