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Murcko scaffold

Ring system with 3 rings and 19 atoms

8 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
8
With full pages
4
Scaffold SMILES

O=C(Nc1nc(-c2ccccc2)cs1)c1cnoc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nc(-c2ccccc2)cs1)c1cnoc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 8 of 8 chemicals

N-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-3,5-dimethyl-1,2-oxazole-4-carboxamide chemical structure, C17H17N3O2S, CAS 878950-36-8
N-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-3,5-dimethyl-1,2-oxazole-4-carboxamide
CAS 878950-36-8C17H17N3O2S
N-[4-(3,4-Difluorophenyl)-1,3-thiazol-2-yl]-3,5-dimethyl-1,2-oxazole-4-carboxamide chemical structure, C15H11F2N3O2S, CAS 878950-46-0
N-[4-(3,4-Difluorophenyl)-1,3-thiazol-2-yl]-3,5-dimethyl-1,2-oxazole-4-carboxamide
CAS 878950-46-0C15H11F2N3O2S
N-[4-(3-Chlorophenyl)-5-methyl-1,3-thiazol-2-yl]-3-ethyl-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C17H16ClN3O2S, CAS 438227-50-0
N-[4-(3-Chlorophenyl)-5-methyl-1,3-thiazol-2-yl]-3-ethyl-5-methyl-1,2-oxazole-4-carboxamide
CAS 438227-50-0C17H16ClN3O2S
N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-3,5-dimethyl-1,2-oxazole-4-carboxamide chemical structure, C16H15N3O3S, CAS 874976-73-5
N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-3,5-dimethyl-1,2-oxazole-4-carboxamide
CAS 874976-73-5C16H15N3O3S
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3,5-dimethyl-1,2-oxazole-4-carboxamide chemical structure, C15H12ClN3O2S, CAS 930681-34-8
N-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3,5-dimethyl-1,2-oxazole-4-carboxamide
CAS 930681-34-8C15H12ClN3O2S
3,5-Dimethyl-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-1,2-oxazole-4-carboxamide chemical structure, C16H15N3O2S, CAS 876916-06-2
3,5-Dimethyl-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-1,2-oxazole-4-carboxamide
CAS 876916-06-2C16H15N3O2S
Ethyl 2-{[(3,5-dimethyl-1,2-oxazol-4-yl)carbonyl]amino}-4-phenyl-1,3-thiazole-5-carboxylate chemical structure, C18H17N3O4S, CAS 926866-35-5
Ethyl 2-{[(3,5-dimethyl-1,2-oxazol-4-yl)carbonyl]amino}-4-phenyl-1,3-thiazole-5-carboxylate
CAS 926866-35-5C18H17N3O4S
3-Ethyl-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-5-methyl-1,2-oxazole-4-carboxamide chemical structure, C17H17N3O3S, CAS 924431-23-2
3-Ethyl-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-5-methyl-1,2-oxazole-4-carboxamide
CAS 924431-23-2C17H17N3O3S