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Murcko scaffold

2-Cyclobutylthiophene scaffold

317 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
317
With full pages
6
Scaffold SMILES

c1csc(C2CCC2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Cyclobutylthiophene page
Murcko scaffold c1csc(C2CCC2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 241 to 288 of 317 chemicals

1-(4-Chlorothiophen-2-yl)-3-hydroxycyclobutane-1-carboxylic acid chemical structure, C9H9ClO3S, CAS 2229429-82-5
1-(4-Chlorothiophen-2-yl)-3-hydroxycyclobutane-1-carboxylic acid
CAS 2229429-82-5C9H9ClO3S
3-(Aminomethyl)-3-[5-(trifluoromethyl)thiophen-2-yl]cyclobutan-1-ol chemical structure, C10H12F3NOS, CAS 2229340-49-0
3-(Aminomethyl)-3-[5-(trifluoromethyl)thiophen-2-yl]cyclobutan-1-ol
CAS 2229340-49-0C10H12F3NOS
{1-[5-(Trifluoromethyl)thiophen-2-yl]cyclobutyl}methanol chemical structure, C10H11F3OS, CAS 2228410-87-3
{1-[5-(Trifluoromethyl)thiophen-2-yl]cyclobutyl}methanol
CAS 2228410-87-3C10H11F3OS
3-Amino-3-(thiophen-2-yl)cyclobutan-1-ol chemical structure, C8H11NOS, CAS 2228340-18-7
3-Amino-3-(thiophen-2-yl)cyclobutan-1-ol
CAS 2228340-18-7C8H11NOS
Methyl 5-[1-(hydroxymethyl)cyclobutyl]thiophene-3-carboxylate chemical structure, C11H14O3S, CAS 2228793-70-0
Methyl 5-[1-(hydroxymethyl)cyclobutyl]thiophene-3-carboxylate
CAS 2228793-70-0C11H14O3S
Methyl 5-(1-amino-3-hydroxycyclobutyl)thiophene-2-carboxylate chemical structure, C10H13NO3S, CAS 2228592-98-9
Methyl 5-(1-amino-3-hydroxycyclobutyl)thiophene-2-carboxylate
CAS 2228592-98-9C10H13NO3S
Methyl 5-(1-aminocyclobutyl)thiophene-2-carboxylate chemical structure, C10H13NO2S, CAS 2229073-26-9
Methyl 5-(1-aminocyclobutyl)thiophene-2-carboxylate
CAS 2229073-26-9C10H13NO2S
3-Amino-3-(4-bromo-5-chlorothiophen-2-yl)cyclobutan-1-ol chemical structure, C8H9BrClNOS, CAS 2228166-36-5
3-Amino-3-(4-bromo-5-chlorothiophen-2-yl)cyclobutan-1-ol
CAS 2228166-36-5C8H9BrClNOS
3-(Aminomethyl)-3-(3-bromo-4-methylthiophen-2-yl)cyclobutan-1-ol chemical structure, C10H14BrNOS, CAS 2228714-11-0
3-(Aminomethyl)-3-(3-bromo-4-methylthiophen-2-yl)cyclobutan-1-ol
CAS 2228714-11-0C10H14BrNOS
3-(Aminomethyl)-3-(3-methylthiophen-2-yl)cyclobutan-1-ol chemical structure, C10H15NOS, CAS 2228278-71-3
3-(Aminomethyl)-3-(3-methylthiophen-2-yl)cyclobutan-1-ol
CAS 2228278-71-3C10H15NOS
3-Amino-3-(5-bromothiophen-2-yl)cyclobutan-1-ol chemical structure, C8H10BrNOS, CAS 2228393-95-9
3-Amino-3-(5-bromothiophen-2-yl)cyclobutan-1-ol
CAS 2228393-95-9C8H10BrNOS
2-(5-Methylthiophen-2-yl)cyclobutan-1-ol chemical structure, C9H12OS, CAS 2161531-33-3
2-(5-Methylthiophen-2-yl)cyclobutan-1-ol
CAS 2161531-33-3C9H12OS
3-Amino-1-(3-ethylthiophen-2-yl)cyclobutane-1-carboxylic acid chemical structure, C11H15NO2S, CAS 2228280-04-2
3-Amino-1-(3-ethylthiophen-2-yl)cyclobutane-1-carboxylic acid
CAS 2228280-04-2C11H15NO2S
3-Amino-1-(4-cyanothiophen-2-yl)cyclobutane-1-carboxylic acid chemical structure, C10H10N2O2S, CAS 2228308-38-9
3-Amino-1-(4-cyanothiophen-2-yl)cyclobutane-1-carboxylic acid
CAS 2228308-38-9C10H10N2O2S
3-Amino-1-(3-chlorothiophen-2-yl)cyclobutane-1-carboxylic acid chemical structure, C9H10ClNO2S, CAS 2228650-95-9
3-Amino-1-(3-chlorothiophen-2-yl)cyclobutane-1-carboxylic acid
CAS 2228650-95-9C9H10ClNO2S
3-Amino-1-(5-bromothiophen-2-yl)cyclobutane-1-carboxylic acid chemical structure, C9H10BrNO2S, CAS 2229189-82-4
3-Amino-1-(5-bromothiophen-2-yl)cyclobutane-1-carboxylic acid
CAS 2229189-82-4C9H10BrNO2S
3-Amino-1-(4-chlorothiophen-2-yl)cyclobutane-1-carboxylic acid chemical structure, C9H10ClNO2S, CAS 2229490-85-9
3-Amino-1-(4-chlorothiophen-2-yl)cyclobutane-1-carboxylic acid
CAS 2229490-85-9C9H10ClNO2S
3-Amino-1-(4-bromothiophen-2-yl)cyclobutane-1-carboxylic acid chemical structure, C9H10BrNO2S, CAS 2229595-83-7
3-Amino-1-(4-bromothiophen-2-yl)cyclobutane-1-carboxylic acid
CAS 2229595-83-7C9H10BrNO2S
3-Amino-1-(5-cyanothiophen-2-yl)cyclobutane-1-carboxylic acid chemical structure, C10H10N2O2S, CAS 2228540-69-8
3-Amino-1-(5-cyanothiophen-2-yl)cyclobutane-1-carboxylic acid
CAS 2228540-69-8C10H10N2O2S
3-Amino-1-(4-methylthiophen-2-yl)cyclobutane-1-carboxylic acid chemical structure, C10H13NO2S, CAS 2228256-83-3
3-Amino-1-(4-methylthiophen-2-yl)cyclobutane-1-carboxylic acid
CAS 2228256-83-3C10H13NO2S
2-[1-(3-Bromo-5-methylthiophen-2-yl)cyclobutyl]ethan-1-amine chemical structure, C11H16BrNS, CAS 2228825-90-7
2-[1-(3-Bromo-5-methylthiophen-2-yl)cyclobutyl]ethan-1-amine
CAS 2228825-90-7C11H16BrNS
1-(4-Bromothiophen-2-yl)cyclobutan-1-amine chemical structure, C8H10BrNS, CAS 2228757-18-2
1-(4-Bromothiophen-2-yl)cyclobutan-1-amine
CAS 2228757-18-2C8H10BrNS
1-(4-Bromo-5-methylthiophen-2-yl)-3,3-difluorocyclobutan-1-amine chemical structure, C9H10BrF2NS, CAS 2228410-99-7
1-(4-Bromo-5-methylthiophen-2-yl)-3,3-difluorocyclobutan-1-amine
CAS 2228410-99-7C9H10BrF2NS
1-(3-Bromo-5-methylthiophen-2-yl)-3,3-difluorocyclobutan-1-amine chemical structure, C9H10BrF2NS, CAS 2228713-23-1
1-(3-Bromo-5-methylthiophen-2-yl)-3,3-difluorocyclobutan-1-amine
CAS 2228713-23-1C9H10BrF2NS