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Murcko scaffold

Ring system with 3 rings and 20 atoms

42 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
42
With full pages
3
Scaffold SMILES

O=C(c1ccccc1)c1ccc(Nc2ccccc2)s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccccc1)c1ccc(Nc2ccccc2)s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

1-(2-Anilino-5-benzoyl-3-thienyl)ethanone chemical structure, C19H15NO2S, CAS 189363-78-8
1-(2-Anilino-5-benzoyl-3-thienyl)ethanone
CAS 189363-78-8C19H15NO2S
4-Amino-2-anilino-5-(4-methylbenzoyl)thiophene-3-carbonitrile chemical structure, C19H15N3OS, CAS 316361-04-3
4-Amino-2-anilino-5-(4-methylbenzoyl)thiophene-3-carbonitrile
CAS 316361-04-3C19H15N3OS
Methyl 2-anilino-5-(4-methoxybenzoyl)-4-methyl-3-thiophenecarboxylate chemical structure, C21H19NO4S, CAS 724735-94-8
Methyl 2-anilino-5-(4-methoxybenzoyl)-4-methyl-3-thiophenecarboxylate
CAS 724735-94-8C21H19NO4S
4-Amino-2-(3-chloroanilino)-5-(3,4-dimethoxybenzoyl)thiophene-3-carbonitrile chemical structure, C20H16ClN3O3S, CAS 445265-82-7
4-Amino-2-(3-chloroanilino)-5-(3,4-dimethoxybenzoyl)thiophene-3-carbonitrile
CAS 445265-82-7C20H16ClN3O3S
4-Amino-2-(2-fluoroanilino)-5-(4-methoxybenzoyl)thiophene-3-carbonitrile chemical structure, C19H14FN3O2S, CAS 499117-47-4
4-Amino-2-(2-fluoroanilino)-5-(4-methoxybenzoyl)thiophene-3-carbonitrile
CAS 499117-47-4C19H14FN3O2S
4-Amino-2-(4-fluoroanilino)-5-(4-fluorobenzoyl)thiophene-3-carbonitrile chemical structure, C18H11F2N3OS, CAS 353461-25-3
4-Amino-2-(4-fluoroanilino)-5-(4-fluorobenzoyl)thiophene-3-carbonitrile
CAS 353461-25-3C18H11F2N3OS
4-Amino-2-anilino-5-(4-chlorobenzoyl)-3-thiophenecarbonitrile chemical structure, C18H12ClN3OS, CAS 328262-53-9
4-Amino-2-anilino-5-(4-chlorobenzoyl)-3-thiophenecarbonitrile
CAS 328262-53-9C18H12ClN3OS
4-Amino-2-anilino-5-benzoyl-3-thiophenecarbonitrile chemical structure, C18H13N3OS, CAS 165824-82-8
4-Amino-2-anilino-5-benzoyl-3-thiophenecarbonitrile
CAS 165824-82-8C18H13N3OS
4-Amino-5-(4-chlorobenzoyl)-2-(2-cyano-4,5-dimethoxyanilino)-3-thiophenecarbonitrile chemical structure, C21H15ClN4O3S, CAS 338959-75-4
4-Amino-5-(4-chlorobenzoyl)-2-(2-cyano-4,5-dimethoxyanilino)-3-thiophenecarbonitrile
CAS 338959-75-4C21H15ClN4O3S
4-Amino-5-(4-chlorobenzoyl)-2-(4-fluoroanilino)thiophene-3-carbonitrile chemical structure, C18H11ClFN3OS, CAS 353461-24-2
4-Amino-5-(4-chlorobenzoyl)-2-(4-fluoroanilino)thiophene-3-carbonitrile
CAS 353461-24-2C18H11ClFN3OS
Ethyl 4-amino-5-(4-chloro-3-nitrobenzoyl)-2-((2-(trifluoromethyl)phenyl)amino)thiophene-3-carboxylate chemical structure, C21H15ClF3N3O5S, CAS 680212-25-3
Ethyl 4-amino-5-(4-chloro-3-nitrobenzoyl)-2-((2-(trifluoromethyl)phenyl)amino)thiophene-3-carboxylate
CAS 680212-25-3C21H15ClF3N3O5S
4-Amino-2-(4-chloroanilino)-5-(2,4-dichlorobenzoyl)-3-thiophenecarbonitrile chemical structure, C18H10Cl3N3OS, CAS 338966-43-1
4-Amino-2-(4-chloroanilino)-5-(2,4-dichlorobenzoyl)-3-thiophenecarbonitrile
CAS 338966-43-1C18H10Cl3N3OS
4-Amino-2-anilino-5-(3,4-dichlorobenzoyl)-3-thiophenecarbonitrile chemical structure, C18H11Cl2N3OS, CAS 338959-74-3
4-Amino-2-anilino-5-(3,4-dichlorobenzoyl)-3-thiophenecarbonitrile
CAS 338959-74-3C18H11Cl2N3OS
4-Amino-5-(4-bromobenzoyl)-2-(3-fluoroanilino)-3-thiophenecarbonitrile chemical structure, C18H11BrFN3OS, CAS 625373-52-6
4-Amino-5-(4-bromobenzoyl)-2-(3-fluoroanilino)-3-thiophenecarbonitrile
CAS 625373-52-6C18H11BrFN3OS
4-Amino-5-(4-bromobenzoyl)-2-(2-fluoroanilino)-3-thiophenecarbonitrile chemical structure, C18H11BrFN3OS, CAS 625373-67-3
4-Amino-5-(4-bromobenzoyl)-2-(2-fluoroanilino)-3-thiophenecarbonitrile
CAS 625373-67-3C18H11BrFN3OS
4-Amino-2-(2-fluoroanilino)-5-(4-fluorobenzoyl)thiophene-3-carbonitrile chemical structure, C18H11F2N3OS, CAS 674806-84-9
4-Amino-2-(2-fluoroanilino)-5-(4-fluorobenzoyl)thiophene-3-carbonitrile
CAS 674806-84-9C18H11F2N3OS
(3-Amino-4-(propylsulfonyl)-5-(o-tolylamino)thiophen-2-yl)(phenyl)methanone chemical structure, C21H22N2O3S2, CAS 890792-96-8
(3-Amino-4-(propylsulfonyl)-5-(o-tolylamino)thiophen-2-yl)(phenyl)methanone
CAS 890792-96-8C21H22N2O3S2
5-Benzoyl-N2-(2,5-dimethylphenyl)-3-(ethanesulfonyl)thiophene-2,4-diamine chemical structure, C21H22N2O3S2, CAS 890792-08-2
5-Benzoyl-N2-(2,5-dimethylphenyl)-3-(ethanesulfonyl)thiophene-2,4-diamine
CAS 890792-08-2C21H22N2O3S2
[5-Anilino-3-(methylamino)-4-nitrothiophen-2-yl](phenyl)methanone chemical structure, C18H15N3O3S, CAS 54252-38-9
[5-Anilino-3-(methylamino)-4-nitrothiophen-2-yl](phenyl)methanone
CAS 54252-38-9C18H15N3O3S
(3-Amino-5-((3-chloro-4-fluorophenyl)amino)-4-(ethylsulfonyl)thiophen-2-yl)(phenyl)methanone chemical structure, C19H16ClFN2O3S2, CAS 890792-72-0
(3-Amino-5-((3-chloro-4-fluorophenyl)amino)-4-(ethylsulfonyl)thiophen-2-yl)(phenyl)methanone
CAS 890792-72-0C19H16ClFN2O3S2
(3-Amino-5-((2-ethyl-6-methylphenyl)amino)-4-(ethylsulfonyl)thiophen-2-yl)(4-fluorophenyl)methanone chemical structure, C22H23FN2O3S2, CAS 890791-84-1
(3-Amino-5-((2-ethyl-6-methylphenyl)amino)-4-(ethylsulfonyl)thiophen-2-yl)(4-fluorophenyl)methanone
CAS 890791-84-1C22H23FN2O3S2
(3-Amino-5-((2-ethyl-6-methylphenyl)amino)-4-(ethylsulfonyl)thiophen-2-yl)(p-tolyl)methanone chemical structure, C23H26N2O3S2, CAS 890792-00-4
(3-Amino-5-((2-ethyl-6-methylphenyl)amino)-4-(ethylsulfonyl)thiophen-2-yl)(p-tolyl)methanone
CAS 890792-00-4C23H26N2O3S2
(3-Amino-5-((2-ethyl-6-methylphenyl)amino)-4-(propylsulfonyl)thiophen-2-yl)(phenyl)methanone chemical structure, C23H26N2O3S2, CAS 890793-60-9
(3-Amino-5-((2-ethyl-6-methylphenyl)amino)-4-(propylsulfonyl)thiophen-2-yl)(phenyl)methanone
CAS 890793-60-9C23H26N2O3S2
(3-Amino-5-((2-ethyl-6-methylphenyl)amino)-4-(propylsulfonyl)thiophen-2-yl)(4-fluorophenyl)methanone chemical structure, C23H25FN2O3S2, CAS 890793-68-7
(3-Amino-5-((2-ethyl-6-methylphenyl)amino)-4-(propylsulfonyl)thiophen-2-yl)(4-fluorophenyl)methanone
CAS 890793-68-7C23H25FN2O3S2