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Murcko scaffold

Ring system with 3 rings and 19 atoms

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
16
With full pages
3
Scaffold SMILES

O=C1CC(c2ccccc2)CN1Cc1ccncc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)CN1Cc1ccncc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

(4R)-1-((3-(Methyl-11C)-4-pyridinyl)methyl)-4-(3,4,5-trifluorophenyl)-2-pyrrolidinone chemical structure, C17H15F3N2O, CAS 2098041-11-1
(4R)-1-((3-(Methyl-11C)-4-pyridinyl)methyl)-4-(3,4,5-trifluorophenyl)-2-pyrrolidinone
CAS 2098041-11-1C17H15F3N2O
1-[(3-Methylpyridin-4-yl)methyl]-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one chemical structure, C17H15F3N2O, CAS 2242777-07-5
1-[(3-Methylpyridin-4-yl)methyl]-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one
CAS 2242777-07-5C17H15F3N2O
(R)-4-(3-Fluoro-5-(trimethylstannyl)phenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidin-2-one chemical structure, C20H25FN2OSn, CAS 2289636-79-7
(R)-4-(3-Fluoro-5-(trimethylstannyl)phenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidin-2-one
CAS 2289636-79-7C20H25FN2OSn
Sdm-8 chemical structure, C17H16F2N2O, CAS 2242777-37-1
Sdm-8
CAS 2242777-37-1C17H16F2N2O
(4R)-1-[(3-Methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one chemical structure, C17H15F3N2O, CAS 2242957-52-2
(4R)-1-[(3-Methyl-4-pyridinyl)methyl]-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one
CAS 2242957-52-2C17H15F3N2O
4-(3-Bromophenyl)-1-[(3-methyl-4-pyridyl)methyl]pyrrolidin-2-one chemical structure, C17H17BrN2O, CAS 2215842-28-5
4-(3-Bromophenyl)-1-[(3-methyl-4-pyridyl)methyl]pyrrolidin-2-one
CAS 2215842-28-5C17H17BrN2O
(4R)-4-(3-Iodophenyl)-1-[(3-methyl-4-pyridinyl)methyl]-2-pyrrolidinone chemical structure, C17H17IN2O, CAS 2215842-31-0
(4R)-4-(3-Iodophenyl)-1-[(3-methyl-4-pyridinyl)methyl]-2-pyrrolidinone
CAS 2215842-31-0C17H17IN2O
(4S)-4-(3-Iodophenyl)-1-[(3-methyl-4-pyridinyl)methyl]-2-pyrrolidinone chemical structure, C17H17IN2O, CAS 2215842-32-1
(4S)-4-(3-Iodophenyl)-1-[(3-methyl-4-pyridinyl)methyl]-2-pyrrolidinone
CAS 2215842-32-1C17H17IN2O
2-Pyrrolidinone, 4-(3-fluorophenyl)-1-((3-methyl-4-pyridinyl)methyl)-, (4R)- chemical structure, C17H17FN2O, CAS 2242776-85-6
2-Pyrrolidinone, 4-(3-fluorophenyl)-1-((3-methyl-4-pyridinyl)methyl)-, (4R)-
CAS 2242776-85-6C17H17FN2O
Sdm-8 F-18 chemical structure, C17H16F2N2O, CAS 2289636-80-0
Sdm-8 F-18
CAS 2289636-80-0C17H16F2N2O
(18F)Ucb-H chemical structure, C16H12F4N2O, CAS 1774352-40-7
(18F)Ucb-H
CAS 1774352-40-7C16H12F4N2O
Br-Dm-UCB-J chemical structure, C16H12BrF3N2O, CAS 2098041-10-0
Br-Dm-UCB-J
CAS 2098041-10-0C16H12BrF3N2O
(S)-1-((3-Methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one chemical structure, C17H15F3N2O, CAS 2242790-26-5
(S)-1-((3-Methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one
CAS 2242790-26-5C17H15F3N2O
(R)-4-(3-Bromo-5-fluorophenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidin-2-one chemical structure, C17H16BrFN2O, CAS 2289636-82-2
(R)-4-(3-Bromo-5-fluorophenyl)-1-((3-methylpyridin-4-yl)methyl)pyrrolidin-2-one
CAS 2289636-82-2C17H16BrFN2O
(R)-1-((3-Iodopyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one chemical structure, C16H12F3IN2O, CAS 2002422-92-4
(R)-1-((3-Iodopyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one
CAS 2002422-92-4C16H12F3IN2O
(R)-4-(3-Bromophenyl)-1-[(3-methyl-4-pyridyl)methyl]pyrrolidin-2-one chemical structure, C17H17BrN2O, CAS 2687893-67-8
(R)-4-(3-Bromophenyl)-1-[(3-methyl-4-pyridyl)methyl]pyrrolidin-2-one
CAS 2687893-67-8C17H17BrN2O