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Murcko scaffold

2,5-Diphenylpyrimidine scaffold

62 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
62
With full pages
5
Scaffold SMILES

c1ccc(-c2cnc(-c3ccccc3)nc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2,5-Diphenylpyrimidine page
Murcko scaffold c1ccc(-c2cnc(-c3ccccc3)nc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 62 chemicals

5-(4-(Pentyloxy)phenyl)-2-(4-pentylphenyl)pyrimidine chemical structure, C26H32N2O, CAS 34913-07-0
5-(4-(Pentyloxy)phenyl)-2-(4-pentylphenyl)pyrimidine
CAS 34913-07-0C26H32N2O
Benzonitrile, 4-[5-(4-butylphenyl)-2-pyrimidinyl]- chemical structure, C21H19N3, CAS 63617-61-8
Benzonitrile, 4-[5-(4-butylphenyl)-2-pyrimidinyl]-
CAS 63617-61-8C21H19N3
4-[5-(4-Hydroxyphenyl)pyrimidin-2-yl]phenol chemical structure, C16H12N2O2, CAS 159488-83-2
4-[5-(4-Hydroxyphenyl)pyrimidin-2-yl]phenol
CAS 159488-83-2C16H12N2O2
2-(4-Butoxyphenyl)-5-(4-hydroxyphenyl)pyrimidine chemical structure, C20H20N2O2, CAS 137780-31-5
2-(4-Butoxyphenyl)-5-(4-hydroxyphenyl)pyrimidine
CAS 137780-31-5C20H20N2O2
5-(4-Butylphenyl)-2-(2-hydroxyphenyl)pyrimidine chemical structure, C20H20N2O, CAS 144104-92-7
5-(4-Butylphenyl)-2-(2-hydroxyphenyl)pyrimidine
CAS 144104-92-7C20H20N2O
2,5-Bis(4-aminophenyl)-pyrimidine chemical structure, C16H14N4, CAS 102570-64-9
2,5-Bis(4-aminophenyl)-pyrimidine
CAS 102570-64-9C16H14N4
2,5-Diphenylpyrimidine chemical structure, C16H12N2, CAS 29134-16-5
2,5-Diphenylpyrimidine
CAS 29134-16-5C16H12N2
2-(4-Bromophenyl)-5-phenylpyrimidine chemical structure, C16H11BrN2, CAS 174720-39-9
2-(4-Bromophenyl)-5-phenylpyrimidine
CAS 174720-39-9C16H11BrN2
N-[4-[2-[4-(2,2-Dimethylpropanoylamino)phenyl]pyrimidin-5-yl]phenyl]-2,2-dimethylpropanamide chemical structure, C26H30N4O2, CAS 328265-68-5
N-[4-[2-[4-(2,2-Dimethylpropanoylamino)phenyl]pyrimidin-5-yl]phenyl]-2,2-dimethylpropanamide
CAS 328265-68-5C26H30N4O2
2-Methyl-N-[4-[2-[4-(2-methylpropanoylamino)phenyl]pyrimidin-5-yl]phenyl]propanamide chemical structure, C24H26N4O2, CAS 355402-88-9
2-Methyl-N-[4-[2-[4-(2-methylpropanoylamino)phenyl]pyrimidin-5-yl]phenyl]propanamide
CAS 355402-88-9C24H26N4O2
3-Methyl-N-[4-[2-[4-(3-methylbutanoylamino)phenyl]pyrimidin-5-yl]phenyl]butanamide chemical structure, C26H30N4O2, CAS 424814-22-2
3-Methyl-N-[4-[2-[4-(3-methylbutanoylamino)phenyl]pyrimidin-5-yl]phenyl]butanamide
CAS 424814-22-2C26H30N4O2
Pyrimidine, 2,5-bis(4-nitrophenyl)- chemical structure, C16H10N4O4, CAS 120493-32-5
Pyrimidine, 2,5-bis(4-nitrophenyl)-
CAS 120493-32-5C16H10N4O4
4,6-Dichloro-2,5-diphenylpyrimidine chemical structure, C16H10Cl2N2, CAS 29133-99-1
4,6-Dichloro-2,5-diphenylpyrimidine
CAS 29133-99-1C16H10Cl2N2
Phenol, 4-[2-[4-(decyloxy)-2,3-difluorophenyl]-5-pyrimidinyl]- chemical structure, C26H30F2N2O2, CAS 167018-92-0
Phenol, 4-[2-[4-(decyloxy)-2,3-difluorophenyl]-5-pyrimidinyl]-
CAS 167018-92-0C26H30F2N2O2
2-Phenyl-5-(o-tolyl)pyrimidine chemical structure, C17H14N2, CAS 70484-43-4
2-Phenyl-5-(o-tolyl)pyrimidine
CAS 70484-43-4C17H14N2
2-(2-Phenylpyrimidin-5-yl)benzoic acid chemical structure, C17H12N2O2, CAS 76646-52-1
2-(2-Phenylpyrimidin-5-yl)benzoic acid
CAS 76646-52-1C17H12N2O2
5-(4-Butyl-3-chlorophenyl)-2-(4-pentylphenyl)pyrimidine chemical structure, C25H29ClN2, CAS 87946-88-1
5-(4-Butyl-3-chlorophenyl)-2-(4-pentylphenyl)pyrimidine
CAS 87946-88-1C25H29ClN2
4-[2-(4-Decoxyphenyl)pyrimidin-5-yl]phenol chemical structure, C26H32N2O2, CAS 119471-77-1
4-[2-(4-Decoxyphenyl)pyrimidin-5-yl]phenol
CAS 119471-77-1C26H32N2O2
2-[2-Fluoro-4-(octyloxy)phenyl]-5-(4-octylphenyl)pyrimidine chemical structure, C32H43FN2O, CAS 126432-67-5
2-[2-Fluoro-4-(octyloxy)phenyl]-5-(4-octylphenyl)pyrimidine
CAS 126432-67-5C32H43FN2O
2-[2-Fluoro-4-(octyloxy)phenyl]-5-(4-heptylphenyl)pyrimidine chemical structure, C31H41FN2O, CAS 124257-09-6
2-[2-Fluoro-4-(octyloxy)phenyl]-5-(4-heptylphenyl)pyrimidine
CAS 124257-09-6C31H41FN2O
2-[2-Fluoro-4-(octyloxy)phenyl]-5-(4-hexylphenyl)pyrimidine chemical structure, C30H39FN2O, CAS 126432-69-7
2-[2-Fluoro-4-(octyloxy)phenyl]-5-(4-hexylphenyl)pyrimidine
CAS 126432-69-7C30H39FN2O
4-{2-[4-(Hexyloxy)phenyl]pyrimidin-5-YL}phenol chemical structure, C22H24N2O2, CAS 126957-47-9
4-{2-[4-(Hexyloxy)phenyl]pyrimidin-5-YL}phenol
CAS 126957-47-9C22H24N2O2
4-(5-(4-Pentylphenyl)pyrimidin-2-yl)benzamide chemical structure, C22H23N3O, CAS 63617-55-0
4-(5-(4-Pentylphenyl)pyrimidin-2-yl)benzamide
CAS 63617-55-0C22H23N3O
4-[5-(4-Pentylphenyl)pyrimidin-2-yl]benzonitrile chemical structure, C22H21N3, CAS 63617-56-1
4-[5-(4-Pentylphenyl)pyrimidin-2-yl]benzonitrile
CAS 63617-56-1C22H21N3