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Murcko scaffold

4,6-Diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione scaffold

27 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
27
With full pages
6
Scaffold SMILES

S=C1NC(c2ccccc2)=CC(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4,6-Diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione page
Murcko scaffold S=C1NC(c2ccccc2)=CC(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

4,6-Diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione chemical structure, C16H14N2S, CAS 6381-55-1
4,6-Diphenyl-1,2,3,4-tetrahydropyrimidine-2-thione
CAS 6381-55-1C16H14N2S
Ethyl 1,2,3,4-tetrahydro-4,6-diphenyl-2-thioxo-5-pyrimidinecarboxylate chemical structure, C19H18N2O2S, CAS 154866-93-0
Ethyl 1,2,3,4-tetrahydro-4,6-diphenyl-2-thioxo-5-pyrimidinecarboxylate
CAS 154866-93-0C19H18N2O2S
Ethyl 4-(2-chlorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C19H17ClN2O2S, CAS 300571-30-6
Ethyl 4-(2-chlorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 300571-30-6C19H17ClN2O2S
6-(4-Bromophenyl)-4-(4-methoxyphenyl)-3,4-dihydropyrimidine-2(1H)-thione chemical structure, C17H15BrN2OS, CAS 331839-20-4
6-(4-Bromophenyl)-4-(4-methoxyphenyl)-3,4-dihydropyrimidine-2(1H)-thione
CAS 331839-20-4C17H15BrN2OS
Ethyl 4-(4-methoxyphenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C20H20N2O3S, CAS 134074-40-1
Ethyl 4-(4-methoxyphenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 134074-40-1C20H20N2O3S
Ethyl 4-(3-methoxyphenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C20H20N2O3S, CAS 397882-36-9
Ethyl 4-(3-methoxyphenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 397882-36-9C20H20N2O3S
2-[2-Ethoxy-4-(5-ethoxycarbonyl-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidin-4-yl)phenoxy]acetic acid chemical structure, C23H24N2O6S, CAS 353518-98-6
2-[2-Ethoxy-4-(5-ethoxycarbonyl-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidin-4-yl)phenoxy]acetic acid
CAS 353518-98-6C23H24N2O6S
Ethyl 4-(3-chlorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C19H17ClN2O2S, CAS 374542-28-6
Ethyl 4-(3-chlorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 374542-28-6C19H17ClN2O2S
Ethyl 6-(5-chloro-2-methoxyphenyl)-4-phenyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate chemical structure, C20H19ClN2O3S, CAS 591761-01-2
Ethyl 6-(5-chloro-2-methoxyphenyl)-4-phenyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate
CAS 591761-01-2C20H19ClN2O3S
Ethyl 6-(2,3-dichlorophenyl)-4-phenyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate chemical structure, C19H16Cl2N2O2S, CAS 452066-15-8
Ethyl 6-(2,3-dichlorophenyl)-4-phenyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate
CAS 452066-15-8C19H16Cl2N2O2S
Ethyl 4-(2-bromophenyl)-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C19H17BrN2O2S, CAS 372974-71-5
Ethyl 4-(2-bromophenyl)-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 372974-71-5C19H17BrN2O2S
4,6-Bis(4-methoxyphenyl)-3,4-dihydropyrimidine-2(1H)-thione chemical structure, C18H18N2O2S, CAS 71834-50-9
4,6-Bis(4-methoxyphenyl)-3,4-dihydropyrimidine-2(1H)-thione
CAS 71834-50-9C18H18N2O2S
4-(3,4-Dimethoxyphenyl)-6-(4-fluorophenyl)-3,4-dihydropyrimidine-2(1H)-thione chemical structure, C18H17FN2O2S, CAS 488132-47-4
4-(3,4-Dimethoxyphenyl)-6-(4-fluorophenyl)-3,4-dihydropyrimidine-2(1H)-thione
CAS 488132-47-4C18H17FN2O2S
2-[4-(5-Acetyl-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidin-4-yl)-2-bromo-6-methoxyphenoxy]acetamide chemical structure, C21H20BrN3O4S, CAS 514221-11-5
2-[4-(5-Acetyl-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidin-4-yl)-2-bromo-6-methoxyphenoxy]acetamide
CAS 514221-11-5C21H20BrN3O4S
6-(4-Methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrimidine-2(1H)-thione chemical structure, C20H22N2O4S, CAS 489399-09-9
6-(4-Methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrimidine-2(1H)-thione
CAS 489399-09-9C20H22N2O4S
1-[4-(2-Bromo-4,5-dimethoxyphenyl)-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidin-5-yl]ethanone chemical structure, C20H19BrN2O3S, CAS 515176-45-1
1-[4-(2-Bromo-4,5-dimethoxyphenyl)-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidin-5-yl]ethanone
CAS 515176-45-1C20H19BrN2O3S
1-[4-(3,4-Dihydroxyphenyl)-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidin-5-yl]ethanone chemical structure, C18H16N2O3S, CAS 692284-20-1
1-[4-(3,4-Dihydroxyphenyl)-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidin-5-yl]ethanone
CAS 692284-20-1C18H16N2O3S
Ethyl 4-(3-fluorophenyl)-6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C19H17FN2O2S, CAS 694442-90-5
Ethyl 4-(3-fluorophenyl)-6-phenyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 694442-90-5C19H17FN2O2S
Ethyl 4-(4-chlorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C19H17ClN2O2S, CAS 372975-55-8
Ethyl 4-(4-chlorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 372975-55-8C19H17ClN2O2S
2(1H)-Pyrimidinethione, 3,4-dihydro-4-(4-nitrophenyl)-6-phenyl- chemical structure, C16H13N3O2S, CAS 295361-40-9
2(1H)-Pyrimidinethione, 3,4-dihydro-4-(4-nitrophenyl)-6-phenyl-
CAS 295361-40-9C16H13N3O2S
Ethyl 6-(4-fluorophenyl)-4-phenyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate chemical structure, C19H17FN2O2S, CAS 353517-09-6
Ethyl 6-(4-fluorophenyl)-4-phenyl-2-sulfanyl-1,6-dihydropyrimidine-5-carboxylate
CAS 353517-09-6C19H17FN2O2S
Ethyl 4-(2-fluorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C19H17FN2O2S, CAS 374104-61-7
Ethyl 4-(2-fluorophenyl)-6-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 374104-61-7C19H17FN2O2S
4-(4-Chlorophenyl)-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione chemical structure, C16H13ClN2S, CAS 71834-45-2
4-(4-Chlorophenyl)-6-phenyl-3,4-dihydropyrimidine-2(1H)-thione
CAS 71834-45-2C16H13ClN2S
Ethyl 4-(4-hydroxyphenyl)-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C19H18N2O3S, CAS 351063-19-9
Ethyl 4-(4-hydroxyphenyl)-6-phenyl-2-sulfanylidene-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 351063-19-9C19H18N2O3S