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Murcko scaffold

Ring system with 3 rings and 23 atoms

19 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
19
With full pages
5
Scaffold SMILES

O=C(NN=Cc1ccccc1)C1CC(=O)N(c2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NN=Cc1ccccc1)C1CC(=O)N(c2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

1-(4-Ethylphenyl)-N-[(4-fluorophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H20FN3O2, CAS 6437-61-2
1-(4-Ethylphenyl)-N-[(4-fluorophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide
CAS 6437-61-2C20H20FN3O2
1-(4-Bromophenyl)-N'-[(E)-(2-chloro-6-fluorophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide chemical structure, C18H14BrClFN3O2, CAS 351188-74-4
1-(4-Bromophenyl)-N'-[(E)-(2-chloro-6-fluorophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide
CAS 351188-74-4C18H14BrClFN3O2
1-(4-Chlorophenyl)-N'-[(E)-(4-methylphenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide chemical structure, C19H18ClN3O2, CAS 339066-88-5
1-(4-Chlorophenyl)-N'-[(E)-(4-methylphenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide
CAS 339066-88-5C19H18ClN3O2
N-[(E)-(2-Methoxyphenyl)methylideneamino]-5-oxo-1-phenylpyrrolidine-3-carboxamide chemical structure, C19H19N3O3, CAS 351188-72-2
N-[(E)-(2-Methoxyphenyl)methylideneamino]-5-oxo-1-phenylpyrrolidine-3-carboxamide
CAS 351188-72-2C19H19N3O3
Disodium 5,10-dianilino-3,8-dichloropyrene-1,6-diyl bis(sulphate) chemical structure, C20H20BrN3O3, CAS 6054-59-7
Disodium 5,10-dianilino-3,8-dichloropyrene-1,6-diyl bis(sulphate)
CAS 6054-59-7C20H20BrN3O3
1-(4-Methylphenyl)-N-[(E)-(4-nitrophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide chemical structure, C19H18N4O4, CAS 351443-99-7
1-(4-Methylphenyl)-N-[(E)-(4-nitrophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide
CAS 351443-99-7C19H18N4O4
Methyl 4-[(E)-(2-{[1-(4-ethylphenyl)-5-oxopyrrolidin-3-yl]carbonyl}hydrazinylidene)methyl]benzoate chemical structure, C22H23N3O4, CAS 351443-97-5
Methyl 4-[(E)-(2-{[1-(4-ethylphenyl)-5-oxopyrrolidin-3-yl]carbonyl}hydrazinylidene)methyl]benzoate
CAS 351443-97-5C22H23N3O4
N-[(E)-(3,4-Dimethoxyphenyl)methylideneamino]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H23N3O5, CAS 351188-73-3
N-[(E)-(3,4-Dimethoxyphenyl)methylideneamino]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 351188-73-3C21H23N3O5
N'-[(E)-(4-Methylphenyl)methylidene]-5-oxo-1-phenylpyrrolidine-3-carbohydrazide chemical structure, C19H19N3O2, CAS 339239-47-3
N'-[(E)-(4-Methylphenyl)methylidene]-5-oxo-1-phenylpyrrolidine-3-carbohydrazide
CAS 339239-47-3C19H19N3O2
Methyl 4-[(E)-(2-{[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]carbonyl}hydrazinylidene)methyl]benzoate chemical structure, C21H21N3O5, CAS 339239-33-7
Methyl 4-[(E)-(2-{[1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl]carbonyl}hydrazinylidene)methyl]benzoate
CAS 339239-33-7C21H21N3O5
N-[(E)-(4-Bromophenyl)methylideneamino]-1-(4-chlorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H15BrClN3O2, CAS 351443-96-4
N-[(E)-(4-Bromophenyl)methylideneamino]-1-(4-chlorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 351443-96-4C18H15BrClN3O2
N'-[(E)-(3-Methoxyphenyl)methylidene]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carbohydrazide chemical structure, C20H21N3O3, CAS 318260-20-7
N'-[(E)-(3-Methoxyphenyl)methylidene]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carbohydrazide
CAS 318260-20-7C20H21N3O3
(E)-Methyl 4-((2-(1-(4-chlorophenyl)-5-oxopyrrolidine-3-carbonyl)hydrazono)methyl)benzoate chemical structure, C20H18ClN3O4, CAS 376613-23-9
(E)-Methyl 4-((2-(1-(4-chlorophenyl)-5-oxopyrrolidine-3-carbonyl)hydrazono)methyl)benzoate
CAS 376613-23-9C20H18ClN3O4
1-(4-Ethylphenyl)-N-[(E)-(3-nitrophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H20N4O4, CAS 351444-00-3
1-(4-Ethylphenyl)-N-[(E)-(3-nitrophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide
CAS 351444-00-3C20H20N4O4
N-[(E)-(2-Chloro-6-fluorophenyl)methylideneamino]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H17ClFN3O2, CAS 352454-09-2
N-[(E)-(2-Chloro-6-fluorophenyl)methylideneamino]-1-(4-methylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 352454-09-2C19H17ClFN3O2
N-[(E)-(2,5-Dimethoxyphenyl)methylideneamino]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C21H23N3O5, CAS 352454-10-5
N-[(E)-(2,5-Dimethoxyphenyl)methylideneamino]-1-(4-methoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 352454-10-5C21H23N3O5
1-(4-Methoxyphenyl)-N'-[(E)-(4-nitrophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide chemical structure, C19H18N4O5, CAS 6063-69-0
1-(4-Methoxyphenyl)-N'-[(E)-(4-nitrophenyl)methylidene]-5-oxopyrrolidine-3-carbohydrazide
CAS 6063-69-0C19H18N4O5
1-(4-Fluorophenyl)-N-[(E)-(3-nitrophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide chemical structure, C18H15FN4O4, CAS 351444-02-5
1-(4-Fluorophenyl)-N-[(E)-(3-nitrophenyl)methylideneamino]-5-oxopyrrolidine-3-carboxamide
CAS 351444-02-5C18H15FN4O4
N'-(2-Chloro-6-fluorobenzylidene)-5-oxo-1-phenyl-3-pyrrolidinecarbohydrazide chemical structure, C18H15ClFN3O2, CAS 352561-14-9
N'-(2-Chloro-6-fluorobenzylidene)-5-oxo-1-phenyl-3-pyrrolidinecarbohydrazide
CAS 352561-14-9C18H15ClFN3O2