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Murcko scaffold

1-Benzyl-5-oxo-N-phenylpyrrolidine-3-carboxamide scaffold

41 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
41
With full pages
5
Scaffold SMILES

O=C(Nc1ccccc1)C1CC(=O)N(Cc2ccccc2)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzyl-5-oxo-N-phenylpyrrolidine-3-carboxamide page
Murcko scaffold O=C(Nc1ccccc1)C1CC(=O)N(Cc2ccccc2)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 41 of 41 chemicals

5-Oxo-N-phenyl-1-[(4-propan-2-ylphenyl)methyl]pyrrolidine-3-carboxamide chemical structure, C21H24N2O2, CAS 404831-88-5
5-Oxo-N-phenyl-1-[(4-propan-2-ylphenyl)methyl]pyrrolidine-3-carboxamide
CAS 404831-88-5C21H24N2O2
1-Benzyl-N-(2,4-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H16Cl2N2O2, CAS 364746-03-2
1-Benzyl-N-(2,4-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 364746-03-2C18H16Cl2N2O2
Isopropyl 4-{[(1-benzyl-5-oxo-3-pyrrolidinyl)carbonyl]amino}benzoate chemical structure, C22H24N2O4, CAS 713081-28-8
Isopropyl 4-{[(1-benzyl-5-oxo-3-pyrrolidinyl)carbonyl]amino}benzoate
CAS 713081-28-8C22H24N2O4
1-Benzyl-N-(4-iodophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H17IN2O2, CAS 713081-30-2
1-Benzyl-N-(4-iodophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 713081-30-2C18H17IN2O2
N-(4-Acetylphenyl)-1-benzyl-5-oxopyrrolidine-3-carboxamide chemical structure, C20H20N2O3, CAS 713081-31-3
N-(4-Acetylphenyl)-1-benzyl-5-oxopyrrolidine-3-carboxamide
CAS 713081-31-3C20H20N2O3
1-Benzyl-N-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H22N2O2, CAS 713081-33-5
1-Benzyl-N-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 713081-33-5C20H22N2O2
1-Benzyl-N-(2,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H16Cl2N2O2, CAS 713081-34-6
1-Benzyl-N-(2,5-dichlorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 713081-34-6C18H16Cl2N2O2
1-Benzyl-N-[2-chloro-5-(trifluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C19H16ClF3N2O2, CAS 713081-36-8
1-Benzyl-N-[2-chloro-5-(trifluoromethyl)phenyl]-5-oxopyrrolidine-3-carboxamide
CAS 713081-36-8C19H16ClF3N2O2
1-Benzyl-N-(4-bromo-2-methylphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H19BrN2O2, CAS 713081-37-9
1-Benzyl-N-(4-bromo-2-methylphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 713081-37-9C19H19BrN2O2
1-Benzyl-N-(4-bromo-2-chlorophenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H16BrClN2O2, CAS 713081-38-0
1-Benzyl-N-(4-bromo-2-chlorophenyl)-5-oxopyrrolidine-3-carboxamide
CAS 713081-38-0C18H16BrClN2O2
N-(3-Chloro-2-methylphenyl)-5-oxo-1-(1-phenylethyl)pyrrolidine-3-carboxamide chemical structure, C20H21ClN2O2, CAS 713081-87-9
N-(3-Chloro-2-methylphenyl)-5-oxo-1-(1-phenylethyl)pyrrolidine-3-carboxamide
CAS 713081-87-9C20H21ClN2O2
N-(3-Methoxyphenyl)-5-oxo-1-(1-phenylethyl)pyrrolidine-3-carboxamide chemical structure, C20H22N2O3, CAS 713081-88-0
N-(3-Methoxyphenyl)-5-oxo-1-(1-phenylethyl)pyrrolidine-3-carboxamide
CAS 713081-88-0C20H22N2O3
N-(4-Bromo-2,3-dimethylphenyl)-5-oxo-1-(1-phenylethyl)pyrrolidine-3-carboxamide chemical structure, C21H23BrN2O2, CAS 713081-89-1
N-(4-Bromo-2,3-dimethylphenyl)-5-oxo-1-(1-phenylethyl)pyrrolidine-3-carboxamide
CAS 713081-89-1C21H23BrN2O2
N-(4-Methylphenyl)-5-oxo-1-(1-phenylethyl)-3-pyrrolidinecarboxamide chemical structure, C20H22N2O2, CAS 879299-64-6
N-(4-Methylphenyl)-5-oxo-1-(1-phenylethyl)-3-pyrrolidinecarboxamide
CAS 879299-64-6C20H22N2O2
1-Benzyl-5-oxo-N-phenylpyrrolidine-3-carboxamide chemical structure, C18H18N2O2, CAS 894732-06-0
1-Benzyl-5-oxo-N-phenylpyrrolidine-3-carboxamide
CAS 894732-06-0C18H18N2O2
1-Benzyl-N-(2-ethoxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H22N2O3, CAS 894734-11-3
1-Benzyl-N-(2-ethoxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 894734-11-3C20H22N2O3
N-(2,4-Dichlorophenyl)-1-(4-methylbenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C19H18Cl2N2O2, CAS 926561-74-2
N-(2,4-Dichlorophenyl)-1-(4-methylbenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 926561-74-2C19H18Cl2N2O2
N-[3-(Acetylamino)phenyl]-1-benzyl-5-oxopyrrolidine-3-carboxamide chemical structure, C20H21N3O3, CAS 1062029-40-6
N-[3-(Acetylamino)phenyl]-1-benzyl-5-oxopyrrolidine-3-carboxamide
CAS 1062029-40-6C20H21N3O3
N-(3-Chloro-4-methylphenyl)-1-(4-methylbenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H21ClN2O2, CAS 903260-84-4
N-(3-Chloro-4-methylphenyl)-1-(4-methylbenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 903260-84-4C20H21ClN2O2
N-(3-Methoxyphenyl)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide chemical structure, C20H22N2O3, CAS 1016354-66-7
N-(3-Methoxyphenyl)-1-[(4-methylphenyl)methyl]-5-oxopyrrolidine-3-carboxamide
CAS 1016354-66-7C20H22N2O3
1-(4-Chlorobenzyl)-N-(3-hydroxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H17ClN2O3, CAS 1081132-83-3
1-(4-Chlorobenzyl)-N-(3-hydroxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 1081132-83-3C18H17ClN2O3
N-[3-(Acetylamino)phenyl]-1-(2-chlorobenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H20ClN3O3, CAS 1081130-60-0
N-[3-(Acetylamino)phenyl]-1-(2-chlorobenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 1081130-60-0C20H20ClN3O3
N-[3-(Acetylamino)phenyl]-1-(4-chlorobenzyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C20H20ClN3O3, CAS 1081137-37-2
N-[3-(Acetylamino)phenyl]-1-(4-chlorobenzyl)-5-oxopyrrolidine-3-carboxamide
CAS 1081137-37-2C20H20ClN3O3
1-(2-Chlorobenzyl)-N-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxamide chemical structure, C18H17ClN2O3, CAS 1081130-96-2
1-(2-Chlorobenzyl)-N-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxamide
CAS 1081130-96-2C18H17ClN2O3