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Murcko scaffold

2-Piperazin-1-ylmethyl-1H-benzoimidazole scaffold

65 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
65
With full pages
9
Scaffold SMILES

c1ccc2[nH]c(CN3CCNCC3)nc2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-Piperazin-1-ylmethyl-1H-benzoimidazole page
Murcko scaffold c1ccc2[nH]c(CN3CCNCC3)nc2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

2-[4-[(1-Butylbenzimidazol-2-yl)methyl]piperazin-1-yl]ethanol chemical structure, C18H28N4O, CAS 896805-49-5
2-[4-[(1-Butylbenzimidazol-2-yl)methyl]piperazin-1-yl]ethanol
CAS 896805-49-5C18H28N4O
1-Butyl-2-[(4-methylpiperazin-1-yl)methyl]benzimidazole chemical structure, C17H26N4, CAS 896857-18-4
1-Butyl-2-[(4-methylpiperazin-1-yl)methyl]benzimidazole
CAS 896857-18-4C17H26N4
1-[4-[(1-Methyl-5-nitrobenzimidazol-2-yl)methyl]piperazin-1-yl]ethanone chemical structure, C15H19N5O3, CAS 696636-14-3
1-[4-[(1-Methyl-5-nitrobenzimidazol-2-yl)methyl]piperazin-1-yl]ethanone
CAS 696636-14-3C15H19N5O3
N-[2-[(4-Acetylpiperazin-1-yl)methyl]-1-methylbenzimidazol-5-yl]methanesulfonamide chemical structure, C16H23N5O3S, CAS 704877-74-7
N-[2-[(4-Acetylpiperazin-1-yl)methyl]-1-methylbenzimidazol-5-yl]methanesulfonamide
CAS 704877-74-7C16H23N5O3S
Ethyl {2-[(4-acetyl-1-piperazinyl)methyl]-1-methyl-1H-benzimidazol-5-yl}carbamate chemical structure, C18H25N5O3, CAS 704877-73-6
Ethyl {2-[(4-acetyl-1-piperazinyl)methyl]-1-methyl-1H-benzimidazol-5-yl}carbamate
CAS 704877-73-6C18H25N5O3
2-Piperazin-1-ylmethyl-1H-benzoimidazole chemical structure, C12H16N4, CAS 59052-85-6
2-Piperazin-1-ylmethyl-1H-benzoimidazole
CAS 59052-85-6C12H16N4
2-[(4-Methylpiperazin-1-yl)methyl]-1-propylbenzimidazole chemical structure, C16H24N4, CAS 896591-87-0
2-[(4-Methylpiperazin-1-yl)methyl]-1-propylbenzimidazole
CAS 896591-87-0C16H24N4
2-[4-[(1-Propylbenzimidazol-2-yl)methyl]piperazin-1-yl]ethanol chemical structure, C17H26N4O, CAS 876889-96-2
2-[4-[(1-Propylbenzimidazol-2-yl)methyl]piperazin-1-yl]ethanol
CAS 876889-96-2C17H26N4O
1-Ethyl-2-[(4-methylpiperazin-1-yl)methyl]benzimidazole chemical structure, C15H22N4, CAS 876889-71-3
1-Ethyl-2-[(4-methylpiperazin-1-yl)methyl]benzimidazole
CAS 876889-71-3C15H22N4
1H-Benzimidazole, 1-(2-(ethenyloxy)ethyl)-2-((4-methyl-1-piperazinyl)methyl)- chemical structure, C17H24N4O, CAS 95894-10-3
1H-Benzimidazole, 1-(2-(ethenyloxy)ethyl)-2-((4-methyl-1-piperazinyl)methyl)-
CAS 95894-10-3C17H24N4O
1-Methyl-2-[(4-methylsulfonylpiperazin-1-yl)methyl]-5-nitrobenzimidazole chemical structure, C14H19N5O4S, CAS 895821-99-5
1-Methyl-2-[(4-methylsulfonylpiperazin-1-yl)methyl]-5-nitrobenzimidazole
CAS 895821-99-5C14H19N5O4S
2-[(4-Methyl-1-piperazinyl)methyl]-6-nitro-1H-benzimidazole chemical structure, C13H17N5O2, CAS 789438-66-0
2-[(4-Methyl-1-piperazinyl)methyl]-6-nitro-1H-benzimidazole
CAS 789438-66-0C13H17N5O2
2-[4-(5-Nitro-1H-benzimidazol-2-ylmethyl)-piperazin-1-yl]-ethanol chemical structure, C14H19N5O3, CAS 703401-07-4
2-[4-(5-Nitro-1H-benzimidazol-2-ylmethyl)-piperazin-1-yl]-ethanol
CAS 703401-07-4C14H19N5O3
2-[4-[(5-Methoxy-1-methylbenzimidazol-2-yl)methyl]piperazin-1-yl]ethanol chemical structure, C16H24N4O2, CAS 878436-55-6
2-[4-[(5-Methoxy-1-methylbenzimidazol-2-yl)methyl]piperazin-1-yl]ethanol
CAS 878436-55-6C16H24N4O2
1-Methyl-2-(piperazinylmethyl)benzimidazole chemical structure, C13H18N4, CAS 59037-72-8
1-Methyl-2-(piperazinylmethyl)benzimidazole
CAS 59037-72-8C13H18N4
Ethyl 4-((1H-benzo[d]imidazol-2-yl)methyl)piperazine-1-carboxylate chemical structure, C15H20N4O2, CAS 94720-60-2
Ethyl 4-((1H-benzo[d]imidazol-2-yl)methyl)piperazine-1-carboxylate
CAS 94720-60-2C15H20N4O2
1-Piperazinecarboxaldehyde, 4-(1H-benzimidazol-2-ylmethyl)- chemical structure, C13H16N4O, CAS 95893-92-8
1-Piperazinecarboxaldehyde, 4-(1H-benzimidazol-2-ylmethyl)-
CAS 95893-92-8C13H16N4O
N-(1-Methyl-2-{[4-(2-methylpropanoyl)piperazin-1-yl]methyl}-1H-benzimidazol-5-yl)acetamide chemical structure, C19H27N5O2, CAS 919721-11-2
N-(1-Methyl-2-{[4-(2-methylpropanoyl)piperazin-1-yl]methyl}-1H-benzimidazol-5-yl)acetamide
CAS 919721-11-2C19H27N5O2
N-(1-Methyl-2-{[4-(2-methylpropanoyl)piperazin-1-yl]methyl}-1H-benzimidazol-5-yl)methanesulfonamide chemical structure, C18H27N5O3S, CAS 919728-82-8
N-(1-Methyl-2-{[4-(2-methylpropanoyl)piperazin-1-yl]methyl}-1H-benzimidazol-5-yl)methanesulfonamide
CAS 919728-82-8C18H27N5O3S
1-Isopropyl-2-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole hydrochloride chemical structure, C16H25ClN4, CAS 1217180-19-2
1-Isopropyl-2-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazole hydrochloride
CAS 1217180-19-2C16H25ClN4
N-(1-Methyl-2-{[4-(2-methylpropanoyl)piperazin-1-yl]methyl}-1H-benzimidazol-5-yl)propanamide chemical structure, C20H29N5O2, CAS 919743-15-0
N-(1-Methyl-2-{[4-(2-methylpropanoyl)piperazin-1-yl]methyl}-1H-benzimidazol-5-yl)propanamide
CAS 919743-15-0C20H29N5O2
2-[4-[(1,5-Dimethylbenzimidazol-2-yl)methyl]piperazin-1-yl]ethanol chemical structure, C16H24N4O, CAS 915915-48-9
2-[4-[(1,5-Dimethylbenzimidazol-2-yl)methyl]piperazin-1-yl]ethanol
CAS 915915-48-9C16H24N4O
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(1-piperazinylmethyl)-, (E)-2-butenedioate, hydrate (1:1:1) chemical structure, C20H30N4O6, CAS 95893-94-0
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-(1-piperazinylmethyl)-, (E)-2-butenedioate, hydrate (1:1:1)
CAS 95893-94-0C20H30N4O6
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-((4-ethyl-1-piperazinyl)methyl)-, (E)-2-butenedioate (2:3) chemical structure, C48H68N8O14, CAS 95894-02-3
1H-Benzimidazole, 1-(2-ethoxyethyl)-2-((4-ethyl-1-piperazinyl)methyl)-, (E)-2-butenedioate (2:3)
CAS 95894-02-3C48H68N8O14