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Murcko scaffold

Ring system with 3 rings and 18 atoms

40 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
40
With full pages
26
Scaffold SMILES

O=c1cnn2c(=O)c(=Cc3ccccc3)sc2n1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1cnn2c(=O)c(=Cc3ccccc3)sc2n1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 40 of 40 chemicals

6-Methyl-2-[[4-(1-methylethyl)phenyl]methylene]-7H-thiazolo[3,2-b][1,2,4]triazine-3,7(2H)-dione chemical structure, C16H15N3O2S, CAS 463364-57-0
6-Methyl-2-[[4-(1-methylethyl)phenyl]methylene]-7H-thiazolo[3,2-b][1,2,4]triazine-3,7(2H)-dione
CAS 463364-57-0C16H15N3O2S
2,6-Dimethyl-4-((Z)-(6-methyl-3,7-dioxo-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazin-2(3H)-ylidene)methyl)phenyl acetate chemical structure, C17H15N3O4S, CAS 606956-55-2
2,6-Dimethyl-4-((Z)-(6-methyl-3,7-dioxo-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazin-2(3H)-ylidene)methyl)phenyl acetate
CAS 606956-55-2C17H15N3O4S
(2E)-2-(3,4-Diethoxybenzylidene)-6-methyl-7H-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7(2H)-dione chemical structure, C17H17N3O4S, CAS 616210-26-5
(2E)-2-(3,4-Diethoxybenzylidene)-6-methyl-7H-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7(2H)-dione
CAS 616210-26-5C17H17N3O4S
(2Z)-2-(4-Chlorobenzylidene)-6-methyl-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione chemical structure, C13H8ClN3O2S, CAS 53047-88-4
(2Z)-2-(4-Chlorobenzylidene)-6-methyl-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione
CAS 53047-88-4C13H8ClN3O2S
2-Benzylidene-6-methyl-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione chemical structure, C13H9N3O2S, CAS 53047-85-1
2-Benzylidene-6-methyl-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione
CAS 53047-85-1C13H9N3O2S
(Z)-2-(4-Methoxybenzylidene)-6-methyl-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione chemical structure, C14H11N3O3S, CAS 53047-86-2
(Z)-2-(4-Methoxybenzylidene)-6-methyl-2H-thiazolo[3,2-b][1,2,4]triazine-3,7-dione
CAS 53047-86-2C14H11N3O3S
(2Z)-2-[(2-Chloro-6-fluorophenyl)methylidene]-6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione chemical structure, C13H7ClFN3O2S, CAS 307506-45-2
(2Z)-2-[(2-Chloro-6-fluorophenyl)methylidene]-6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
CAS 307506-45-2C13H7ClFN3O2S
4-((E)-(6-Methyl-3,7-dioxo-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazin-2(3H)-ylidene)methyl)phenyl acetate chemical structure, C15H11N3O4S, CAS 463959-51-5
4-((E)-(6-Methyl-3,7-dioxo-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazin-2(3H)-ylidene)methyl)phenyl acetate
CAS 463959-51-5C15H11N3O4S
(2Z)-6-Methyl-2-[(4-propoxyphenyl)methylidene]-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione chemical structure, C16H15N3O3S, CAS 380882-14-4
(2Z)-6-Methyl-2-[(4-propoxyphenyl)methylidene]-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
CAS 380882-14-4C16H15N3O3S
(2Z)-6-Methyl-2-[(2-nitrophenyl)methylidene]-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione chemical structure, C13H8N4O4S, CAS 325996-98-3
(2Z)-6-Methyl-2-[(2-nitrophenyl)methylidene]-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
CAS 325996-98-3C13H8N4O4S
(2Z)-2-[(4-Butoxy-3-methoxyphenyl)methylidene]-6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione chemical structure, C18H19N3O4S, CAS 381191-84-0
(2Z)-2-[(4-Butoxy-3-methoxyphenyl)methylidene]-6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
CAS 381191-84-0C18H19N3O4S
(2Z)-6-Methyl-2-[(4-prop-2-enoxyphenyl)methylidene]-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione chemical structure, C16H13N3O3S, CAS 378222-72-1
(2Z)-6-Methyl-2-[(4-prop-2-enoxyphenyl)methylidene]-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
CAS 378222-72-1C16H13N3O3S
(2Z)-6-Methyl-2-[(3-nitrophenyl)methylidene]-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione chemical structure, C13H8N4O4S, CAS 325997-00-0
(2Z)-6-Methyl-2-[(3-nitrophenyl)methylidene]-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
CAS 325997-00-0C13H8N4O4S
(2Z)-6-Methyl-2-(2-propoxybenzylidene)-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione chemical structure, C16H15N3O3S, CAS 609794-94-7
(2Z)-6-Methyl-2-(2-propoxybenzylidene)-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione
CAS 609794-94-7C16H15N3O3S
(2E)-2-(4-Butoxy-3-ethoxybenzylidene)-6-methyl-7H-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7(2H)-dione chemical structure, C19H21N3O4S, CAS 616213-59-3
(2E)-2-(4-Butoxy-3-ethoxybenzylidene)-6-methyl-7H-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7(2H)-dione
CAS 616213-59-3C19H21N3O4S
(2Z)-2-[3-Methoxy-4-(octyloxy)benzylidene]-6-methyl-7H-[1,3]thiazolo[3,2-B][1,2,4]triazine-3,7(2H)-dione chemical structure, C22H27N3O4S, CAS 617694-34-5
(2Z)-2-[3-Methoxy-4-(octyloxy)benzylidene]-6-methyl-7H-[1,3]thiazolo[3,2-B][1,2,4]triazine-3,7(2H)-dione
CAS 617694-34-5C22H27N3O4S
(2E)-6-Methyl-2-[2-(pentyloxy)benzylidene]-7H-[1,3]thiazolo[3,2-B][1,2,4]triazine-3,7(2H)-dione chemical structure, C18H19N3O3S, CAS 617694-60-7
(2E)-6-Methyl-2-[2-(pentyloxy)benzylidene]-7H-[1,3]thiazolo[3,2-B][1,2,4]triazine-3,7(2H)-dione
CAS 617694-60-7C18H19N3O3S
(2Z)-2-(3-Ethoxy-4-propoxybenzylidene)-6-methyl-7H-[1,3]thiazolo[3,2-B][1,2,4]triazine-3,7(2H)-dione chemical structure, C18H19N3O4S, CAS 617694-39-0
(2Z)-2-(3-Ethoxy-4-propoxybenzylidene)-6-methyl-7H-[1,3]thiazolo[3,2-B][1,2,4]triazine-3,7(2H)-dione
CAS 617694-39-0C18H19N3O4S
(2E)-2-[(2-Butoxyphenyl)methylidene]-6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione chemical structure, C17H17N3O3S, CAS 608120-09-8
(2E)-2-[(2-Butoxyphenyl)methylidene]-6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
CAS 608120-09-8C17H17N3O3S
(2E)-2-(2-(Hexyloxy)benzylidene)-6-methyl-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione chemical structure, C19H21N3O3S, CAS 617695-18-8
(2E)-2-(2-(Hexyloxy)benzylidene)-6-methyl-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione
CAS 617695-18-8C19H21N3O3S
2-(4-Ethylbenzylidene)-6-ME-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione chemical structure, C15H13N3O2S, CAS 606955-88-8
2-(4-Ethylbenzylidene)-6-ME-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione
CAS 606955-88-8C15H13N3O2S
(2Z)-2-(2,5-Dimethoxybenzylidene)-6-methyl-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione chemical structure, C15H13N3O4S, CAS 606955-36-6
(2Z)-2-(2,5-Dimethoxybenzylidene)-6-methyl-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione
CAS 606955-36-6C15H13N3O4S
(2E)-2-(4-(Dimethylamino)benzylidene)-6-methyl-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione chemical structure, C15H14N4O2S, CAS 463364-55-8
(2E)-2-(4-(Dimethylamino)benzylidene)-6-methyl-7H-(1,3)thiazolo(3,2-B)(1,2,4)triazine-3,7(2H)-dione
CAS 463364-55-8C15H14N4O2S
(2Z)-2-[(3-Bromophenyl)methylidene]-6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione chemical structure, C13H8BrN3O2S, CAS 463367-03-5
(2Z)-2-[(3-Bromophenyl)methylidene]-6-methyl-[1,3]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
CAS 463367-03-5C13H8BrN3O2S