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Murcko scaffold

Ring system with 3 rings and 18 atoms

48 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
48
With full pages
20
Scaffold SMILES

O=c1[nH]c(=O)c2[nH]c(CN3CCOCC3)nc2[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1[nH]c(=O)c2[nH]c(CN3CCOCC3)nc2[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 48 chemicals

3-Methyl-8-(morpholin-4-ylmethyl)-7H-purine-2,6-dione chemical structure, C11H15N5O3, CAS 838874-68-3
3-Methyl-8-(morpholin-4-ylmethyl)-7H-purine-2,6-dione
CAS 838874-68-3C11H15N5O3
7-(2,3-Dihydroxypropyl)-1,3-dimethyl-8-(morpholinomethyl)-1H-purine-2,6(3H,7H)-dione chemical structure, C15H23N5O5, CAS 577766-03-1
7-(2,3-Dihydroxypropyl)-1,3-dimethyl-8-(morpholinomethyl)-1H-purine-2,6(3H,7H)-dione
CAS 577766-03-1C15H23N5O5
7-(2,3-Dihydroxypropyl)-8-[(2,6-dimethylmorpholin-4-yl)methyl]-1,3-dimethylpurine-2,6-dione chemical structure, C17H27N5O5, CAS 1005262-35-0
7-(2,3-Dihydroxypropyl)-8-[(2,6-dimethylmorpholin-4-yl)methyl]-1,3-dimethylpurine-2,6-dione
CAS 1005262-35-0C17H27N5O5
8-[(2,6-Dimethylmorpholin-4-yl)methyl]-7-(3-hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione chemical structure, C17H27N5O4, CAS 838881-75-7
8-[(2,6-Dimethylmorpholin-4-yl)methyl]-7-(3-hydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
CAS 838881-75-7C17H27N5O4
1,3-Dimethyl-7-(2-methylallyl)-8-(morpholinomethyl)-1H-purine-2,6(3H,7H)-dione chemical structure, C16H23N5O3, CAS 573931-49-4
1,3-Dimethyl-7-(2-methylallyl)-8-(morpholinomethyl)-1H-purine-2,6(3H,7H)-dione
CAS 573931-49-4C16H23N5O3
7-Ethyl-1,3-dimethyl-8-(morpholin-4-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione chemical structure, C14H21N5O3, CAS 838876-89-4
7-Ethyl-1,3-dimethyl-8-(morpholin-4-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione
CAS 838876-89-4C14H21N5O3
1,3-Dimethyl-8-(morpholin-4-ylmethyl)-7-propan-2-ylpurine-2,6-dione chemical structure, C15H23N5O3, CAS 797028-32-1
1,3-Dimethyl-8-(morpholin-4-ylmethyl)-7-propan-2-ylpurine-2,6-dione
CAS 797028-32-1C15H23N5O3
1,3-Dimethyl-7-(2-methylpropyl)-8-(morpholin-4-ylmethyl)purine-2,6-dione chemical structure, C16H25N5O3, CAS 843622-87-7
1,3-Dimethyl-7-(2-methylpropyl)-8-(morpholin-4-ylmethyl)purine-2,6-dione
CAS 843622-87-7C16H25N5O3
1,3-Dimethyl-8-(morpholin-4-ylmethyl)-7H-purine-2,6-dione chemical structure, C12H17N5O3, CAS 108871-83-6
1,3-Dimethyl-8-(morpholin-4-ylmethyl)-7H-purine-2,6-dione
CAS 108871-83-6C12H17N5O3
1,3-Dimethyl-8-morpholin-4-ylmethyl-7-propyl-3,7-dihydro-purine-2,6-dione chemical structure, C15H23N5O3, CAS 585563-69-5
1,3-Dimethyl-8-morpholin-4-ylmethyl-7-propyl-3,7-dihydro-purine-2,6-dione
CAS 585563-69-5C15H23N5O3
1,3-Dimethyl-8-(morpholinomethyl)-7-(2-oxopropyl)-1H-purine-2,6(3H,7H)-dione chemical structure, C15H21N5O4, CAS 587012-22-4
1,3-Dimethyl-8-(morpholinomethyl)-7-(2-oxopropyl)-1H-purine-2,6(3H,7H)-dione
CAS 587012-22-4C15H21N5O4
Ethyl [1,3-dimethyl-8-(morpholin-4-ylmethyl)-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl]acetate chemical structure, C16H23N5O5, CAS 573950-86-4
Ethyl [1,3-dimethyl-8-(morpholin-4-ylmethyl)-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl]acetate
CAS 573950-86-4C16H23N5O5
3-Methyl-7-(2-methylprop-2-enyl)-8-(morpholin-4-ylmethyl)purine-2,6-dione chemical structure, C15H21N5O3, CAS 868143-62-8
3-Methyl-7-(2-methylprop-2-enyl)-8-(morpholin-4-ylmethyl)purine-2,6-dione
CAS 868143-62-8C15H21N5O3
8-[(2,6-Dimethylmorpholin-4-yl)methyl]-3-methyl-7H-purine-2,6-dione chemical structure, C13H19N5O3, CAS 838873-58-8
8-[(2,6-Dimethylmorpholin-4-yl)methyl]-3-methyl-7H-purine-2,6-dione
CAS 838873-58-8C13H19N5O3
8-((2,6-Dimethylmorpholino)methyl)-1,3-dimethyl-7-(3-oxobutan-2-yl)-1H-purine-2,6(3H,7H)-dione chemical structure, C18H27N5O4, CAS 1005127-17-2
8-((2,6-Dimethylmorpholino)methyl)-1,3-dimethyl-7-(3-oxobutan-2-yl)-1H-purine-2,6(3H,7H)-dione
CAS 1005127-17-2C18H27N5O4
7-Butyl-1,3-dimethyl-8-(morpholin-4-ylmethyl)purine-2,6-dione chemical structure, C16H25N5O3, CAS 573697-31-1
7-Butyl-1,3-dimethyl-8-(morpholin-4-ylmethyl)purine-2,6-dione
CAS 573697-31-1C16H25N5O3
1,3-Dimethyl-8-(morpholinomethyl)-7-(3-oxobutan-2-yl)-1H-purine-2,6(3H,7H)-dione chemical structure, C16H23N5O4, CAS 573933-25-2
1,3-Dimethyl-8-(morpholinomethyl)-7-(3-oxobutan-2-yl)-1H-purine-2,6(3H,7H)-dione
CAS 573933-25-2C16H23N5O4
7-(2-Methoxyethyl)-1,3-dimethyl-8-(morpholin-4-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione chemical structure, C15H23N5O4, CAS 573707-05-8
7-(2-Methoxyethyl)-1,3-dimethyl-8-(morpholin-4-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione
CAS 573707-05-8C15H23N5O4
8-[(2,6-Dimethylmorpholin-4-yl)methyl]-1,3-dimethyl-7-(3-methylbutyl)-3,7-dihydro-1H-purine-2,6-dione chemical structure, C19H31N5O3, CAS 838905-06-9
8-[(2,6-Dimethylmorpholin-4-yl)methyl]-1,3-dimethyl-7-(3-methylbutyl)-3,7-dihydro-1H-purine-2,6-dione
CAS 838905-06-9C19H31N5O3
7-(2-Ethoxyethyl)-1,3-dimethyl-8-(morpholinomethyl)-1H-purine-2,6(3H,7H)-dione chemical structure, C16H25N5O4, CAS 577769-09-6
7-(2-Ethoxyethyl)-1,3-dimethyl-8-(morpholinomethyl)-1H-purine-2,6(3H,7H)-dione
CAS 577769-09-6C16H25N5O4
8-[(2,6-Dimethylmorpholin-4-yl)methyl]-1,3-dimethyl-7H-purine-2,6-dione chemical structure, C14H21N5O3, CAS 673493-99-7
8-[(2,6-Dimethylmorpholin-4-yl)methyl]-1,3-dimethyl-7H-purine-2,6-dione
CAS 673493-99-7C14H21N5O3
7-(3,3-Dimethyl-2-oxobutyl)-1,3-dimethyl-8-(morpholin-4-ylmethyl)purine-2,6-dione chemical structure, C18H27N5O4, CAS 878420-90-7
7-(3,3-Dimethyl-2-oxobutyl)-1,3-dimethyl-8-(morpholin-4-ylmethyl)purine-2,6-dione
CAS 878420-90-7C18H27N5O4
1,3-Dimethyl-8-(morpholin-4-ylmethyl)-7-nonylpurine-2,6-dione chemical structure, C21H35N5O3, CAS 676156-01-7
1,3-Dimethyl-8-(morpholin-4-ylmethyl)-7-nonylpurine-2,6-dione
CAS 676156-01-7C21H35N5O3
7-Hexyl-1,3-dimethyl-8-(morpholin-4-ylmethyl)purine-2,6-dione chemical structure, C18H29N5O3, CAS 851942-04-6
7-Hexyl-1,3-dimethyl-8-(morpholin-4-ylmethyl)purine-2,6-dione
CAS 851942-04-6C18H29N5O3