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Murcko scaffold

Ring system with 2 rings and 18 atoms

15 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
18
Chemicals
15
With full pages
11
Scaffold SMILES

O=C(C=Cc1ccccc1)NC1CCS(=O)(=O)C1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1ccccc1)NC1CCS(=O)(=O)C1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

(2E)-N-(1,1-Dioxothiolan-3-yl)-3-(2-chlorophenyl)prop-2-enamide chemical structure, C13H14ClNO3S, CAS 324071-00-3
(2E)-N-(1,1-Dioxothiolan-3-yl)-3-(2-chlorophenyl)prop-2-enamide
CAS 324071-00-3C13H14ClNO3S
2-Cyano-3-[4-(diethylamino)phenyl]-N-(1,1-dioxo-1lambda6-thiolan-3-yl)prop-2-enamide chemical structure, C18H23N3O3S, CAS 324567-12-6
2-Cyano-3-[4-(diethylamino)phenyl]-N-(1,1-dioxo-1lambda6-thiolan-3-yl)prop-2-enamide
CAS 324567-12-6C18H23N3O3S
(E)-3-(4-tert-Butylphenyl)-N-(1,1-dioxothiolan-3-yl)prop-2-enamide chemical structure, C17H23NO3S, CAS 431926-31-7
(E)-3-(4-tert-Butylphenyl)-N-(1,1-dioxothiolan-3-yl)prop-2-enamide
CAS 431926-31-7C17H23NO3S
N-(1,1-Dioxidotetrahydro-3-thienyl)-N-methyl-3-phenylacrylamide chemical structure, C14H17NO3S, CAS 1164460-32-5
N-(1,1-Dioxidotetrahydro-3-thienyl)-N-methyl-3-phenylacrylamide
CAS 1164460-32-5C14H17NO3S
(E)-3-(4-Chlorophenyl)-N-(1,1-dioxothiolan-3-yl)prop-2-enamide chemical structure, C13H14ClNO3S, CAS 324546-91-0
(E)-3-(4-Chlorophenyl)-N-(1,1-dioxothiolan-3-yl)prop-2-enamide
CAS 324546-91-0C13H14ClNO3S
(E)-2-Cyano-N-(1,1-dioxothiolan-3-yl)-3-(4-ethylphenyl)prop-2-enamide chemical structure, C16H18N2O3S, CAS 381704-94-5
(E)-2-Cyano-N-(1,1-dioxothiolan-3-yl)-3-(4-ethylphenyl)prop-2-enamide
CAS 381704-94-5C16H18N2O3S
(E)-2-Cyano-N-(1,1-dioxothiolan-3-yl)-3-(3-methoxyphenyl)prop-2-enamide chemical structure, C15H16N2O4S, CAS 1164541-52-9
(E)-2-Cyano-N-(1,1-dioxothiolan-3-yl)-3-(3-methoxyphenyl)prop-2-enamide
CAS 1164541-52-9C15H16N2O4S
(E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-3-(4-methoxyphenyl)acrylamide chemical structure, C14H17NO4S, CAS 515125-92-5
(E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-3-(4-methoxyphenyl)acrylamide
CAS 515125-92-5C14H17NO4S
(E)-3-(3-Bromo-4-hydroxy-5-methoxyphenyl)-2-cyano-N-(1,1-dioxidotetrahydrothiophen-3-yl)acrylamide chemical structure, C15H15BrN2O5S, CAS 618065-29-5
(E)-3-(3-Bromo-4-hydroxy-5-methoxyphenyl)-2-cyano-N-(1,1-dioxidotetrahydrothiophen-3-yl)acrylamide
CAS 618065-29-5C15H15BrN2O5S
(E)-3-(4-Methoxyphenyl)-N-methyl-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)acrylamide chemical structure, C16H21NO4S, CAS 874594-49-7
(E)-3-(4-Methoxyphenyl)-N-methyl-N-(3-methyl-1,1-dioxidotetrahydrothiophen-3-yl)acrylamide
CAS 874594-49-7C16H21NO4S
(E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-3-(4-methoxyphenyl)-N-methylacrylamide chemical structure, C15H19NO4S, CAS 874594-55-5
(E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-3-(4-methoxyphenyl)-N-methylacrylamide
CAS 874594-55-5C15H19NO4S
(E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-ethyl-3-(4-methoxyphenyl)acrylamide chemical structure, C16H21NO4S, CAS 874787-52-7
(E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-ethyl-3-(4-methoxyphenyl)acrylamide
CAS 874787-52-7C16H21NO4S
(E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-isobutyl-3-(4-methoxyphenyl)acrylamide chemical structure, C18H25NO4S, CAS 874788-39-3
(E)-N-(1,1-Dioxidotetrahydrothiophen-3-yl)-N-isobutyl-3-(4-methoxyphenyl)acrylamide
CAS 874788-39-3C18H25NO4S
N-Butyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)cinnamamide chemical structure, C17H23NO3S, CAS 898405-37-3
N-Butyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)cinnamamide
CAS 898405-37-3C17H23NO3S
(E)-N-Butyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-methoxyphenyl)acrylamide chemical structure, C18H25NO4S, CAS 898425-95-1
(E)-N-Butyl-N-(1,1-dioxidotetrahydrothiophen-3-yl)-3-(4-methoxyphenyl)acrylamide
CAS 898425-95-1C18H25NO4S