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Murcko scaffold

Ring system with 2 rings and 16 atoms

23 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
16
Chemicals
23
With full pages
5
Scaffold SMILES

O=C(CSc1nncs1)NC1CCCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nncs1)NC1CCCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 23 of 23 chemicals

2-((5-Acetamido-1,3,4-thiadiazol-2-yl)thio)-N-cyclohexylacetamide chemical structure, C12H18N4O2S2, CAS 531547-82-7
2-((5-Acetamido-1,3,4-thiadiazol-2-yl)thio)-N-cyclohexylacetamide
CAS 531547-82-7C12H18N4O2S2
2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-cyclohexylacetamide chemical structure, C10H16N4OS2, CAS 690689-63-5
2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-cyclohexylacetamide
CAS 690689-63-5C10H16N4OS2
2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-(4-methylcyclohexyl)acetamide chemical structure, C11H18N4OS2, CAS 849134-90-3
2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-(4-methylcyclohexyl)acetamide
CAS 849134-90-3C11H18N4OS2
2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-cyclohexyl-N-methylacetamide chemical structure, C11H18N4OS2, CAS 849054-33-7
2-((5-Amino-1,3,4-thiadiazol-2-yl)thio)-N-cyclohexyl-N-methylacetamide
CAS 849054-33-7C11H18N4OS2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(1-cyanocyclohexyl)acetamide chemical structure, C11H15N5OS2, CAS 848905-08-8
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(1-cyanocyclohexyl)acetamide
CAS 848905-08-8C11H15N5OS2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(1-cyanocyclohexyl)propanamide chemical structure, C12H17N5OS2, CAS 848907-11-9
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(1-cyanocyclohexyl)propanamide
CAS 848907-11-9C12H17N5OS2
N-(1-Cyanocyclohexyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide chemical structure, C13H18N4OS2, CAS 848904-19-8
N-(1-Cyanocyclohexyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
CAS 848904-19-8C13H18N4OS2
N-(1-Cyanocyclohexyl)-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanamide chemical structure, C12H16N4OS2, CAS 848905-42-0
N-(1-Cyanocyclohexyl)-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanamide
CAS 848905-42-0C12H16N4OS2
N-(1-Cyanocyclohexyl)-N-methyl-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide chemical structure, C12H16N4OS2, CAS 876697-05-1
N-(1-Cyanocyclohexyl)-N-methyl-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide
CAS 876697-05-1C12H16N4OS2
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(2-methylcyclohexyl)propanamide chemical structure, C12H20N4OS2, CAS 1005265-44-0
2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(2-methylcyclohexyl)propanamide
CAS 1005265-44-0C12H20N4OS2
N-(1-Cyanocyclohexyl)-2-({5-[(propan-2-yl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C14H21N5OS2, CAS 923744-44-9
N-(1-Cyanocyclohexyl)-2-({5-[(propan-2-yl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide
CAS 923744-44-9C14H21N5OS2
N-(1-Cyanocyclohexyl)-N-methyl-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanamide chemical structure, C13H18N4OS2, CAS 930848-86-5
N-(1-Cyanocyclohexyl)-N-methyl-2-(1,3,4-thiadiazol-2-ylsulfanyl)propanamide
CAS 930848-86-5C13H18N4OS2
N-(1-Cyanocyclohexyl)-N-methyl-2-{[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl}propanamide chemical structure, C14H21N5OS2, CAS 931616-69-2
N-(1-Cyanocyclohexyl)-N-methyl-2-{[5-(methylamino)-1,3,4-thiadiazol-2-yl]sulfanyl}propanamide
CAS 931616-69-2C14H21N5OS2
2-((5-(3-(tert-Butyl)ureido)-1,3,4-thiadiazol-2-yl)thio)-N-cyclohexylacetamide chemical structure, C15H25N5O2S2, CAS 886940-77-8
2-((5-(3-(tert-Butyl)ureido)-1,3,4-thiadiazol-2-yl)thio)-N-cyclohexylacetamide
CAS 886940-77-8C15H25N5O2S2
2-{[5-(Butylamino)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(1-cyanocyclohexyl)-N-methylacetamide chemical structure, C16H25N5OS2, CAS 1012170-55-6
2-{[5-(Butylamino)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(1-cyanocyclohexyl)-N-methylacetamide
CAS 1012170-55-6C16H25N5OS2
N-(5-((2-(Cyclohexylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-methylbutanamide chemical structure, C15H24N4O2S2, CAS 893148-53-3
N-(5-((2-(Cyclohexylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-3-methylbutanamide
CAS 893148-53-3C15H24N4O2S2
N-(5-((2-(Cyclohexylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)pentanamide chemical structure, C15H24N4O2S2, CAS 893347-18-7
N-(5-((2-(Cyclohexylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)pentanamide
CAS 893347-18-7C15H24N4O2S2
N-(1-Cyanocyclohexyl)-N-methyl-2-[[5-(2-methylpropylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide chemical structure, C16H24N4OS3, CAS 1240830-15-2
N-(1-Cyanocyclohexyl)-N-methyl-2-[[5-(2-methylpropylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
CAS 1240830-15-2C16H24N4OS3
2-{[5-({[(1-Cyanocyclohexyl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N,N-diethylacetamide chemical structure, C17H25N5O2S3, CAS 1110958-06-9
2-{[5-({[(1-Cyanocyclohexyl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N,N-diethylacetamide
CAS 1110958-06-9C17H25N5O2S3
Acetamide, 2-[[5-[(2-methoxyethyl)amino]-1,3,4-thiadiazol-2-yl]thio]-N-(2-methylcyclohexyl)- chemical structure, C14H24N4O2S2, CAS 1008075-44-2
Acetamide, 2-[[5-[(2-methoxyethyl)amino]-1,3,4-thiadiazol-2-yl]thio]-N-(2-methylcyclohexyl)-
CAS 1008075-44-2C14H24N4O2S2
N-(1-Cyanocyclohexyl)-2-({5-[(2-methoxyethyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)propanamide chemical structure, C15H23N5O2S2, CAS 1209069-19-1
N-(1-Cyanocyclohexyl)-2-({5-[(2-methoxyethyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)propanamide
CAS 1209069-19-1C15H23N5O2S2
N-(1-Cyanocyclohexyl)-N-methyl-2-({5-[(2-methylpropyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)propanamide chemical structure, C17H26N4OS3, CAS 1209058-64-9
N-(1-Cyanocyclohexyl)-N-methyl-2-({5-[(2-methylpropyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)propanamide
CAS 1209058-64-9C17H26N4OS3
N-(1-Cyanocyclohexyl)-2-({5-[(2-methylpropyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)propanamide chemical structure, C16H25N5OS2, CAS 1326421-92-4
N-(1-Cyanocyclohexyl)-2-({5-[(2-methylpropyl)amino]-1,3,4-thiadiazol-2-yl}sulfanyl)propanamide
CAS 1326421-92-4C16H25N5OS2