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Murcko scaffold

1,4-Dioxa-7-azaspiro(4.4)nonane scaffold

51 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
9
Chemicals
51
With full pages
7
Scaffold SMILES

C1CC2(CN1)OCCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1,4-Dioxa-7-azaspiro(4.4)nonane page
Murcko scaffold C1CC2(CN1)OCCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 51 of 51 chemicals

(8R)-7-[(Prop-2-en-1-yloxy)carbonyl]-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid chemical structure, C11H15NO6, CAS 2920084-91-7
(8R)-7-[(Prop-2-en-1-yloxy)carbonyl]-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS 2920084-91-7C11H15NO6
(8R)-7-Acetyl-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid chemical structure, C9H13NO5, CAS 2920085-64-7
(8R)-7-Acetyl-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS 2920085-64-7C9H13NO5
(8R)-7-(2,2,2-Trifluoroacetyl)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid chemical structure, C9H10F3NO5, CAS 2920089-06-9
(8R)-7-(2,2,2-Trifluoroacetyl)-1,4-dioxa-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS 2920089-06-9C9H10F3NO5