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Murcko scaffold

Ring system with 3 rings and 18 atoms

24 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 18
Chemicals: 24
With full pages: 3

Scaffold SMILES

C(=Cc1nc(-c2ccccc2)cs1)c1cccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold C(=Cc1nc(-c2ccccc2)cs1)c1cccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

(E)-2-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-3-thiophen-2-ylprop-2-enenitrile chemical structure, C16H9FN2S2, CAS 277756-72-6

(E)-2-[4-(4-Fluorophenyl)-1,3-thiazol-2-yl]-3-thiophen-2-ylprop-2-enenitrile

CAS 277756-72-6C₁₆H₉FN₂S₂

2-(4-(4-Methoxy-phenyl)-thiazol-2-yl)-3-thiophen-2-YL-acrylonitrile chemical structure, C17H12N2OS2, CAS 5315-32-2

2-(4-(4-Methoxy-phenyl)-thiazol-2-yl)-3-thiophen-2-YL-acrylonitrile

CAS 5315-32-2C₁₇H₁₂N₂OS₂

(Z)-2-(4-(4-Chlorophenyl)thiazol-2-yl)-3-(5-methylthiophen-2-yl)acrylonitrile chemical structure, C17H11ClN2S2, CAS 327167-48-6

(Z)-2-(4-(4-Chlorophenyl)thiazol-2-yl)-3-(5-methylthiophen-2-yl)acrylonitrile

CAS 327167-48-6C₁₇H₁₁ClN₂S₂

(Z)-2-(4-(4-Bromophenyl)thiazol-2-yl)-3-(5-methylthiophen-2-yl)acrylonitrile chemical structure, C17H11BrN2S2, CAS 327169-36-8

(Z)-2-(4-(4-Bromophenyl)thiazol-2-yl)-3-(5-methylthiophen-2-yl)acrylonitrile

CAS 327169-36-8C₁₇H₁₁BrN₂S₂

(E)-2-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-3-thiophen-2-ylprop-2-enenitrile chemical structure, C16H9BrN2S2, CAS 277756-71-5

(E)-2-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-3-thiophen-2-ylprop-2-enenitrile

CAS 277756-71-5C₁₆H₉BrN₂S₂

(Z)-2-(4-(4-Methoxyphenyl)thiazol-2-yl)-3-(3-methylthiophen-2-yl)acrylonitrile chemical structure, C18H14N2OS2, CAS 316358-06-2

(Z)-2-(4-(4-Methoxyphenyl)thiazol-2-yl)-3-(3-methylthiophen-2-yl)acrylonitrile

CAS 316358-06-2C₁₈H₁₄N₂OS₂

(Z)-2-(4-(4-Bromophenyl)thiazol-2-yl)-3-(3-methylthiophen-2-yl)acrylonitrile chemical structure, C17H11BrN2S2, CAS 332175-27-6

(Z)-2-(4-(4-Bromophenyl)thiazol-2-yl)-3-(3-methylthiophen-2-yl)acrylonitrile

CAS 332175-27-6C₁₇H₁₁BrN₂S₂

2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-(3-methyl-2-thienyl)acrylonitrile chemical structure, C17H11ClN2S2, CAS 332175-26-5

2-[4-(4-Chlorophenyl)-1,3-thiazol-2-yl]-3-(3-methyl-2-thienyl)acrylonitrile

CAS 332175-26-5C₁₇H₁₁ClN₂S₂

(E)-2-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-3-(3-methylthiophen-2-yl)prop-2-enenitrile chemical structure, C18H14N2S2, CAS 5910-49-6

(E)-2-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-3-(3-methylthiophen-2-yl)prop-2-enenitrile

CAS 5910-49-6C₁₈H₁₄N₂S₂

(2Z)-2-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-3-(5-methylthiophen-2-yl)prop-2-enenitrile chemical structure, C18H14N2S2, CAS 5922-18-9

(2Z)-2-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-3-(5-methylthiophen-2-yl)prop-2-enenitrile

CAS 5922-18-9C₁₈H₁₄N₂S₂

(Z)-2-(4-(4-Methoxyphenyl)thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile chemical structure, C17H12N2OS2, CAS 277756-76-0

(Z)-2-(4-(4-Methoxyphenyl)thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile

CAS 277756-76-0C₁₇H₁₂N₂OS₂

(E)-2-(4-(4-Chlorophenyl)thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile chemical structure, C16H9ClN2S2, CAS 277756-73-7

(E)-2-(4-(4-Chlorophenyl)thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile

CAS 277756-73-7C₁₆H₉ClN₂S₂

(E)-3-(Thiophen-2-yl)-2-(4-(p-tolyl)thiazol-2-yl)acrylonitrile chemical structure, C17H12N2S2, CAS 277756-79-3

(E)-3-(Thiophen-2-yl)-2-(4-(p-tolyl)thiazol-2-yl)acrylonitrile

CAS 277756-79-3C₁₇H₁₂N₂S₂

(E)-2-[4-(4-Butylphenyl)-1,3-thiazol-2-yl]-3-thiophen-2-ylprop-2-enenitrile chemical structure, C20H18N2S2, CAS 312757-87-2

(E)-2-[4-(4-Butylphenyl)-1,3-thiazol-2-yl]-3-thiophen-2-ylprop-2-enenitrile

CAS 312757-87-2C₂₀H₁₈N₂S₂

(E)-2-(4-Phenylthiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile chemical structure, C16H10N2S2, CAS 243975-40-8

(E)-2-(4-Phenylthiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile

CAS 243975-40-8C₁₆H₁₀N₂S₂

(E)-2-(4-(3,4-Dichlorophenyl)thiazol-2-yl)-3-(3-methylthiophen-2-yl)acrylonitrile chemical structure, C17H10Cl2N2S2, CAS 476675-13-5

(E)-2-(4-(3,4-Dichlorophenyl)thiazol-2-yl)-3-(3-methylthiophen-2-yl)acrylonitrile

CAS 476675-13-5C₁₇H₁₀Cl₂N₂S₂

(E)-2-(4-(4-Ethoxyphenyl)thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile chemical structure, C18H14N2OS2, CAS 313687-61-5

(E)-2-(4-(4-Ethoxyphenyl)thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile

CAS 313687-61-5C₁₈H₁₄N₂OS₂

(E)-2-(4-(4-Methoxyphenyl)thiazol-2-yl)-3-(5-methylthiophen-2-yl)acrylonitrile chemical structure, C18H14N2OS2, CAS 328068-78-6

(E)-2-(4-(4-Methoxyphenyl)thiazol-2-yl)-3-(5-methylthiophen-2-yl)acrylonitrile

CAS 328068-78-6C₁₈H₁₄N₂OS₂

(Z)-3-(5-Methylthiophen-2-yl)-2-(4-phenylthiazol-2-yl)acrylonitrile chemical structure, C17H12N2S2, CAS 332175-28-7

(Z)-3-(5-Methylthiophen-2-yl)-2-(4-phenylthiazol-2-yl)acrylonitrile

CAS 332175-28-7C₁₇H₁₂N₂S₂

(Z)-2-(4-(3-Bromophenyl)thiazol-2-yl)-3-(3-methylthiophen-2-yl)acrylonitrile chemical structure, C17H11BrN2S2, CAS 423734-67-2

(Z)-2-(4-(3-Bromophenyl)thiazol-2-yl)-3-(3-methylthiophen-2-yl)acrylonitrile

CAS 423734-67-2C₁₇H₁₁BrN₂S₂

(2Z)-2-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-(3-methylthiophen-2-yl)prop-2-enenitrile chemical structure, C17H10Cl2N2S2, CAS 476675-12-4

(2Z)-2-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-3-(3-methylthiophen-2-yl)prop-2-enenitrile

CAS 476675-12-4C₁₇H₁₀Cl₂N₂S₂

(E)-2-(4-(4-Isobutylphenyl)thiazol-2-yl)-3-(3-methylthiophen-2-yl)acrylonitrile chemical structure, C21H20N2S2, CAS 1321897-66-8

(E)-2-(4-(4-Isobutylphenyl)thiazol-2-yl)-3-(3-methylthiophen-2-yl)acrylonitrile

CAS 1321897-66-8C₂₁H₂₀N₂S₂

(E)-3-(5-Bromothiophen-2-yl)-2-(4-phenylthiazol-2-yl)acrylonitrile chemical structure, C16H9BrN2S2, CAS 1049119-78-9

(E)-3-(5-Bromothiophen-2-yl)-2-(4-phenylthiazol-2-yl)acrylonitrile

CAS 1049119-78-9C₁₆H₉BrN₂S₂

(2Z)-2-[4-(3-Methoxyphenyl)-1,3-thiazol-2-yl]-3-(thiophen-2-yl)prop-2-enenitrile chemical structure, C17H12N2OS2, CAS 476675-19-1

(2Z)-2-[4-(3-Methoxyphenyl)-1,3-thiazol-2-yl]-3-(thiophen-2-yl)prop-2-enenitrile

CAS 476675-19-1C₁₇H₁₂N₂OS₂