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Murcko scaffold

Ring system with 4 rings and 25 atoms

565 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
565
With full pages
14
Scaffold SMILES

O=C(NCC1CCCCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCC1CCCCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 433 to 480 of 565 chemicals

2-[2-({1-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)ethoxy]acetic acid chemical structure, C27H32N2O6, CAS 2172439-46-0
2-[2-({1-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)ethoxy]acetic acid
CAS 2172439-46-0C27H32N2O6
2-(1-{3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}-N-methylformamido)-2-methylpropanoic acid chemical structure, C28H34N2O5, CAS 2172483-47-3
2-(1-{3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}-N-methylformamido)-2-methylpropanoic acid
CAS 2172483-47-3C28H34N2O5
(2R)-2-({3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)-3-hydroxypropanoic acid chemical structure, C26H30N2O6, CAS 2648935-33-3
(2R)-2-({3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)-3-hydroxypropanoic acid
CAS 2648935-33-3C26H30N2O6
3-(4,4-Difluorocyclohexyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid chemical structure, C24H25F2NO4, CAS 2288073-66-3
3-(4,4-Difluorocyclohexyl)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CAS 2288073-66-3C24H25F2NO4
rac-3-[(1R,3S)-3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl]prop-2-ynoic acid chemical structure, C25H25NO4, CAS 2382587-68-8
rac-3-[(1R,3S)-3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl]prop-2-ynoic acid
CAS 2382587-68-8C25H25NO4
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-[3-(trifluoromethyl)cyclohexyl]acetic acid chemical structure, C24H24F3NO4, CAS 2156805-89-7
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-[3-(trifluoromethyl)cyclohexyl]acetic acid
CAS 2156805-89-7C24H24F3NO4
2-[(1-{2-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}-N-methylformamido)oxy]acetic acid chemical structure, C26H30N2O6, CAS 2172512-16-0
2-[(1-{2-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}-N-methylformamido)oxy]acetic acid
CAS 2172512-16-0C26H30N2O6
4-(2-{1-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}acetamido)but-2-ynoic acid chemical structure, C28H30N2O5, CAS 2172493-02-4
4-(2-{1-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}acetamido)but-2-ynoic acid
CAS 2172493-02-4C28H30N2O5
(2R)-2-({3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)-4-hydroxybutanoic acid chemical structure, C27H32N2O6, CAS 2648932-70-9
(2R)-2-({3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)-4-hydroxybutanoic acid
CAS 2648932-70-9C27H32N2O6
2-({3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)butanoic acid chemical structure, C27H32N2O5, CAS 2171714-78-4
2-({3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)butanoic acid
CAS 2171714-78-4C27H32N2O5
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(2-methoxycyclohexyl)acetic acid chemical structure, C24H27NO5, CAS 1849647-15-9
2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2-(2-methoxycyclohexyl)acetic acid
CAS 1849647-15-9C24H27NO5
(2S)-2-({1-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-4-methylcyclohexyl}formamido)butanoic acid chemical structure, C28H34N2O5, CAS 2171238-03-0
(2S)-2-({1-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]-4-methylcyclohexyl}formamido)butanoic acid
CAS 2171238-03-0C28H34N2O5
2-(N-Ethyl-1-{3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)acetic acid chemical structure, C27H32N2O5, CAS 2172091-45-9
2-(N-Ethyl-1-{3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)acetic acid
CAS 2172091-45-9C27H32N2O5
3-({3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)butanoic acid chemical structure, C27H32N2O5, CAS 2172557-13-8
3-({3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)butanoic acid
CAS 2172557-13-8C27H32N2O5
(2S,3R)-2-({3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)-3-hydroxybutanoic acid chemical structure, C27H32N2O6, CAS 2648917-71-7
(2S,3R)-2-({3-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}formamido)-3-hydroxybutanoic acid
CAS 2648917-71-7C27H32N2O6
3-(1-{2-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}-N-methylformamido)propanoic acid chemical structure, C27H32N2O5, CAS 2172437-81-7
3-(1-{2-[({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclohexyl}-N-methylformamido)propanoic acid
CAS 2172437-81-7C27H32N2O5
(9H-Fluoren-9-yl)methyl N-{[1-(2-hydroxyethyl)cyclohexyl]methyl}carbamate chemical structure, C24H29NO3, CAS 2764015-27-0
(9H-Fluoren-9-yl)methyl N-{[1-(2-hydroxyethyl)cyclohexyl]methyl}carbamate
CAS 2764015-27-0C24H29NO3
(9H-Fluoren-9-yl)methyl N-{[(1r,4r)-4-(hydroxymethyl)cyclohexyl]methyl}carbamate chemical structure, C23H27NO3, CAS 2763887-82-5
(9H-Fluoren-9-yl)methyl N-{[(1r,4r)-4-(hydroxymethyl)cyclohexyl]methyl}carbamate
CAS 2763887-82-5C23H27NO3
(9H-Fluoren-9-yl)methyl N-{[(1R,2S,5R)-1-hydroxy-5-methyl-2-(propan-2-yl)cyclohexyl]methyl}carbamate chemical structure, C26H33NO3, CAS 2763894-92-2
(9H-Fluoren-9-yl)methyl N-{[(1R,2S,5R)-1-hydroxy-5-methyl-2-(propan-2-yl)cyclohexyl]methyl}carbamate
CAS 2763894-92-2C26H33NO3
(9H-Fluoren-9-yl)methyl N-(2-cyclohexyl-1-hydroxypropan-2-yl)carbamate chemical structure, C24H29NO3, CAS 2763916-28-3
(9H-Fluoren-9-yl)methyl N-(2-cyclohexyl-1-hydroxypropan-2-yl)carbamate
CAS 2763916-28-3C24H29NO3
(9H-Fluoren-9-yl)methyl N-[1-(1-hydroxycyclohexyl)ethyl]carbamate chemical structure, C23H27NO3, CAS 2763919-00-0
(9H-Fluoren-9-yl)methyl N-[1-(1-hydroxycyclohexyl)ethyl]carbamate
CAS 2763919-00-0C23H27NO3
(9H-Fluoren-9-yl)methyl N-[1-(4,4-difluorocyclohexyl)-3-hydroxypropyl]carbamate chemical structure, C24H27F2NO3, CAS 2763955-50-4
(9H-Fluoren-9-yl)methyl N-[1-(4,4-difluorocyclohexyl)-3-hydroxypropyl]carbamate
CAS 2763955-50-4C24H27F2NO3
(9H-Fluoren-9-yl)methyl N-{[4-(difluoromethyl)-1-(2-hydroxyethoxy)cyclohexyl]methyl}carbamate chemical structure, C25H29F2NO4, CAS 2763999-64-8
(9H-Fluoren-9-yl)methyl N-{[4-(difluoromethyl)-1-(2-hydroxyethoxy)cyclohexyl]methyl}carbamate
CAS 2763999-64-8C25H29F2NO4
rac-(9H-Fluoren-9-yl)methyl N-{[(1R,3S)-3-(hydroxymethyl)cyclohexyl]methyl}carbamate chemical structure, C23H27NO3, CAS 2763946-92-3
rac-(9H-Fluoren-9-yl)methyl N-{[(1R,3S)-3-(hydroxymethyl)cyclohexyl]methyl}carbamate
CAS 2763946-92-3C23H27NO3