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Murcko scaffold

Ring system with 3 rings and 18 atoms

32 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
32
With full pages
5
Scaffold SMILES

c1ccc(-c2nccc(N3CCOCC3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2nccc(N3CCOCC3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

4-(6-Methyl-2-phenylpyrimidin-4-yl)morpholine chemical structure, C15H17N3O, CAS 83216-95-9
4-(6-Methyl-2-phenylpyrimidin-4-yl)morpholine
CAS 83216-95-9C15H17N3O
2-(4-Methyl-6-morpholin-4-yl-pyrimidin-2-yl)-phenol chemical structure, C15H17N3O2, CAS 300358-29-6
2-(4-Methyl-6-morpholin-4-yl-pyrimidin-2-yl)-phenol
CAS 300358-29-6C15H17N3O2
Ethyl 4-morpholin-4-yl-2-phenylpyrimidine-5-carboxylate chemical structure, C17H19N3O3, CAS 439094-76-5
Ethyl 4-morpholin-4-yl-2-phenylpyrimidine-5-carboxylate
CAS 439094-76-5C17H19N3O3
4-(6-Chloro-2-phenyl-4-pyrimidinyl)morpholine chemical structure, C14H14ClN3O, CAS 343373-72-8
4-(6-Chloro-2-phenyl-4-pyrimidinyl)morpholine
CAS 343373-72-8C14H14ClN3O
4-(6-((Methylsulfanyl)methyl)-2-phenyl-4-pyrimidinyl)morpholine chemical structure, C16H19N3OS, CAS 477886-25-2
4-(6-((Methylsulfanyl)methyl)-2-phenyl-4-pyrimidinyl)morpholine
CAS 477886-25-2C16H19N3OS
4-[6-(Methoxymethyl)-2-phenylpyrimidin-4-yl]morpholine chemical structure, C16H19N3O2, CAS 339278-90-9
4-[6-(Methoxymethyl)-2-phenylpyrimidin-4-yl]morpholine
CAS 339278-90-9C16H19N3O2
Methyl (6-morpholino-2-phenyl-4-pyrimidinyl)methyl sulfone chemical structure, C16H19N3O3S, CAS 339278-96-5
Methyl (6-morpholino-2-phenyl-4-pyrimidinyl)methyl sulfone
CAS 339278-96-5C16H19N3O3S
Ethyl 4-(2,6-dimethylmorpholin-4-yl)-2-phenylpyrimidine-5-carboxylate chemical structure, C19H23N3O3, CAS 477854-61-8
Ethyl 4-(2,6-dimethylmorpholin-4-yl)-2-phenylpyrimidine-5-carboxylate
CAS 477854-61-8C19H23N3O3
4-Pyrimidineacetamide, 2-(4-chlorophenyl)-N-hydroxy-6-(4-morpholinyl)- chemical structure, C16H17ClN4O3, CAS 42055-64-1
4-Pyrimidineacetamide, 2-(4-chlorophenyl)-N-hydroxy-6-(4-morpholinyl)-
CAS 42055-64-1C16H17ClN4O3
4-Pyrimidineacetamide, N-hydroxy-6-(4-morpholinyl)-2-(3,4,5-trimethoxyphenyl)- chemical structure, C19H24N4O6, CAS 42055-67-4
4-Pyrimidineacetamide, N-hydroxy-6-(4-morpholinyl)-2-(3,4,5-trimethoxyphenyl)-
CAS 42055-67-4C19H24N4O6
4-Pyrimidineacetamide, N-hydroxy-6-(4-morpholinyl)-2-(3-(trifluoromethyl)phenyl)- chemical structure, C17H17F3N4O3, CAS 42055-71-0
4-Pyrimidineacetamide, N-hydroxy-6-(4-morpholinyl)-2-(3-(trifluoromethyl)phenyl)-
CAS 42055-71-0C17H17F3N4O3
4-Pyrimidineacetamide, 2-(3-chlorophenyl)-N-hydroxy-6-(4-morpholinyl)- chemical structure, C16H17ClN4O3, CAS 42055-76-5
4-Pyrimidineacetamide, 2-(3-chlorophenyl)-N-hydroxy-6-(4-morpholinyl)-
CAS 42055-76-5C16H17ClN4O3
4-Pyrimidineacetamide, 2-(3-fluorophenyl)-N-hydroxy-6-(4-morpholinyl)- chemical structure, C16H17FN4O3, CAS 42055-82-3
4-Pyrimidineacetamide, 2-(3-fluorophenyl)-N-hydroxy-6-(4-morpholinyl)-
CAS 42055-82-3C16H17FN4O3
4-(5-Methoxy-2-phenylpyrimidin-4-yl)morpholine chemical structure, C15H17N3O2, CAS 477863-69-7
4-(5-Methoxy-2-phenylpyrimidin-4-yl)morpholine
CAS 477863-69-7C15H17N3O2
4-[6-(Methoxymethyl)-2-phenylpyrimidin-4-yl]-2,6-dimethylmorpholine chemical structure, C18H23N3O2, CAS 339278-95-4
4-[6-(Methoxymethyl)-2-phenylpyrimidin-4-yl]-2,6-dimethylmorpholine
CAS 339278-95-4C18H23N3O2
4-(5-Methoxy-2-phenyl-4-pyrimidinyl)-2,6-dimethylmorpholine chemical structure, C17H21N3O2, CAS 477863-83-5
4-(5-Methoxy-2-phenyl-4-pyrimidinyl)-2,6-dimethylmorpholine
CAS 477863-83-5C17H21N3O2
Methyl (6-morpholino-2-phenyl-4-pyrimidinyl)methyl sulfoxide chemical structure, C16H19N3O2S, CAS 338967-72-9
Methyl (6-morpholino-2-phenyl-4-pyrimidinyl)methyl sulfoxide
CAS 338967-72-9C16H19N3O2S
4-[(E)-2-(Dimethylamino)ethenyl]-2-(3-hydroxyphenyl)-6-morpholin-4-ylpyrimidine-5-carbonitrile chemical structure, C19H21N5O2, CAS 1309087-83-9
4-[(E)-2-(Dimethylamino)ethenyl]-2-(3-hydroxyphenyl)-6-morpholin-4-ylpyrimidine-5-carbonitrile
CAS 1309087-83-9C19H21N5O2
4-Chloro-2-(3-hydroxyphenyl)-6-morpholinopyrimidine chemical structure, C14H14ClN3O2, CAS 873566-68-8
4-Chloro-2-(3-hydroxyphenyl)-6-morpholinopyrimidine
CAS 873566-68-8C14H14ClN3O2
3-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]benzamide chemical structure, C17H20N4O4S, CAS 944057-14-1
3-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]benzamide
CAS 944057-14-1C17H20N4O4S
[3-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]methanol chemical structure, C17H21N3O4S, CAS 944057-09-4
[3-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]methanol
CAS 944057-09-4C17H21N3O4S
[4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]methanol chemical structure, C17H21N3O4S, CAS 944057-10-7
[4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]methanol
CAS 944057-10-7C17H21N3O4S
Methyl 2-amino-5-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]benzoate chemical structure, C18H22N4O5S, CAS 944057-90-3
Methyl 2-amino-5-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]benzoate
CAS 944057-90-3C18H22N4O5S
4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline chemical structure, C16H20N4O3S, CAS 944058-10-0
4-[4-(Methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine-2-yl]aniline
CAS 944058-10-0C16H20N4O3S