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Murcko scaffold

Pyrazolo(1,5-a)pyrimidine scaffold

2,195 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 9
Chemicals: 2,195
With full pages: 244

Scaffold SMILES

c1cnc2ccnn2c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the Pyrazolo(1,5-a)pyrimidine page

Murcko scaffold c1cnc2ccnn2c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 2,195 chemicals

Ethyl 5,7-bis(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C11H9F4N3O2, CAS 512823-09-5

Ethyl 5,7-bis(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

CAS 512823-09-5C₁₁H₉F₄N₃O₂

5-Isopropyl-7-trifluoromethyl-pyrazolo-[1,5-a]pyrimidine-2-carboxylic acid chemical structure, C11H10F3N3O2, CAS 436088-49-2

5-Isopropyl-7-trifluoromethyl-pyrazolo-[1,5-a]pyrimidine-2-carboxylic acid

CAS 436088-49-2C₁₁H₁₀F₃N₃O₂

5-Methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile chemical structure, C9H5F3N4, CAS 444144-39-2

5-Methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

CAS 444144-39-2C₉H₅F₃N₄

Ethyl 5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C11H10F3N3O2, CAS 514799-12-3

Ethyl 5-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate

CAS 514799-12-3C₁₁H₁₀F₃N₃O₂

7-(Chlorodifluoromethyl)-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxylic acid chemical structure, C9H6ClF2N3O2, CAS 676522-75-1

7-(Chlorodifluoromethyl)-5-methylpyrazolo[1,5-a]pyrimidine-2-carboxylic acid

CAS 676522-75-1C₉H₆ClF₂N₃O₂

5-tert-Butyl-2-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C11H16N4, CAS 714278-28-1

5-tert-Butyl-2-methylpyrazolo[1,5-a]pyrimidin-7-amine

CAS 714278-28-1C₁₁H₁₆N₄

Ethyl 7-amino-3-cyano-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate chemical structure, C11H11N5O2, CAS 701228-22-0

Ethyl 7-amino-3-cyano-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

CAS 701228-22-0C₁₁H₁₁N₅O₂

Ethyl 7-amino-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate chemical structure, C10H12N4O2, CAS 2627-58-9

Ethyl 7-amino-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate

CAS 2627-58-9C₁₀H₁₂N₄O₂

3-Chloro-6-(2-hydroxyethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid chemical structure, C9H8ClN3O3, CAS 842974-84-9

3-Chloro-6-(2-hydroxyethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

CAS 842974-84-9C₉H₈ClN₃O₃

Pyrazolo(1,5-a)pyrimidine-2-carboxylic acid, 3-chloro-5-methyl-7-(trifluoromethyl)- chemical structure, C9H5ClF3N3O2, CAS 524036-11-1

Pyrazolo(1,5-a)pyrimidine-2-carboxylic acid, 3-chloro-5-methyl-7-(trifluoromethyl)-

CAS 524036-11-1C₉H₅ClF₃N₃O₂

Ethyl 7-(difluoromethyl)-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate chemical structure, C11H11F2N3O2, CAS 438218-16-7

Ethyl 7-(difluoromethyl)-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate

CAS 438218-16-7C₁₁H₁₁F₂N₃O₂

5-(Difluoromethyl)-2,7-dimethylpyrazolo[1,5-a]pyrimidine chemical structure, C9H9F2N3, CAS 438224-02-3

5-(Difluoromethyl)-2,7-dimethylpyrazolo[1,5-a]pyrimidine

CAS 438224-02-3C₉H₉F₂N₃

5,7-Bis(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid chemical structure, C9H5F4N3O2, CAS 438228-65-0

5,7-Bis(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

CAS 438228-65-0C₉H₅F₄N₃O₂

6-(2-Hydroxyethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid chemical structure, C9H9N3O3, CAS 712319-12-5

6-(2-Hydroxyethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

CAS 712319-12-5C₉H₉N₃O₃

6-Bromo-3-nitropyrazolo[1,5-a]pyrimidine chemical structure, C6H3BrN4O2, CAS 300361-77-7

6-Bromo-3-nitropyrazolo[1,5-a]pyrimidine

CAS 300361-77-7C₆H₃BrN₄O₂

7-Amino-2-methylpyrazolo[1,5-a]pyrimidine-6-carbonitrile chemical structure, C8H7N5, CAS 255389-59-4

7-Amino-2-methylpyrazolo[1,5-a]pyrimidine-6-carbonitrile

CAS 255389-59-4C₈H₇N₅

2-(7-Chloro-3-cyano-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)ethyl acetate chemical structure, C12H11ClN4O2, CAS 865658-51-1

2-(7-Chloro-3-cyano-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)ethyl acetate

CAS 865658-51-1C₁₂H₁₁ClN₄O₂

7-(Dimethoxymethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile chemical structure, C10H10N4O2, CAS 478046-33-2

7-(Dimethoxymethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile

CAS 478046-33-2C₁₀H₁₀N₄O₂

7-(Dimethoxymethyl)-2-methylpyrazolo[1,5-a]pyrimidine chemical structure, C10H13N3O2, CAS 478046-46-7

7-(Dimethoxymethyl)-2-methylpyrazolo[1,5-a]pyrimidine

CAS 478046-46-7C₁₀H₁₃N₃O₂

6-Methanesulfonyl-2-methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C8H10N4O2S, CAS 439108-98-2

6-Methanesulfonyl-2-methylpyrazolo[1,5-a]pyrimidin-7-amine

CAS 439108-98-2C₈H₁₀N₄O₂S

2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxamide chemical structure, C8H8N4O, CAS 338953-49-4

2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxamide

CAS 338953-49-4C₈H₈N₄O

2-Methylpyrazolo[1,5-a]pyrimidin-7-amine chemical structure, C7H8N4, CAS 2369-83-7

2-Methylpyrazolo[1,5-a]pyrimidin-7-amine

CAS 2369-83-7C₇H₈N₄

Ethyl 3-bromo-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate chemical structure, C11H9BrF3N3O2, CAS 685108-14-9

Ethyl 3-bromo-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate

CAS 685108-14-9C₁₁H₉BrF₃N₃O₂

Ethyl 3-chloro-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate chemical structure, C11H9ClF3N3O2, CAS 685108-15-0

Ethyl 3-chloro-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate

CAS 685108-15-0C₁₁H₉ClF₃N₃O₂