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Murcko scaffold

Ring system with 3 rings and 18 atoms

22 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
22
With full pages
2
Scaffold SMILES

c1ccc(Cc2ccc(-c3ccccc3)s2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Cc2ccc(-c3ccccc3)s2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene chemical structure, C18H14FIS, CAS 898566-17-1
2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene
CAS 898566-17-1C18H14FIS
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene chemical structure, C18H14BrFS, CAS 1030825-20-7
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
CAS 1030825-20-7C18H14BrFS
2-(4-Fluorophenyl)-5-(2-methylbenzyl)thiophene chemical structure, C18H15FS, CAS 2005454-69-1
2-(4-Fluorophenyl)-5-(2-methylbenzyl)thiophene
CAS 2005454-69-1C18H15FS
2-(4-Fluorophenyl)-5-[(2-methyl-5-nitrophenyl)methyl]thiophene chemical structure, C18H14FNO2S, CAS 1312810-93-7
2-(4-Fluorophenyl)-5-[(2-methyl-5-nitrophenyl)methyl]thiophene
CAS 1312810-93-7C18H14FNO2S
2-(5-Bromo-2-methylbenzyl)-5-phenylthiophene chemical structure, C18H15BrS, CAS 842137-12-6
2-(5-Bromo-2-methylbenzyl)-5-phenylthiophene
CAS 842137-12-6C18H15BrS
3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenol chemical structure, C18H15FOS, CAS 2338840-88-1
3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenol
CAS 2338840-88-1C18H15FOS
3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylbenzaldehyde chemical structure, C19H15FOS, CAS 2443502-91-6
3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylbenzaldehyde
CAS 2443502-91-6C19H15FOS
2-(5-Iodo-2-methylbenzyl)-5-phenylthiophene chemical structure, C18H15IS, CAS 2444540-01-4
2-(5-Iodo-2-methylbenzyl)-5-phenylthiophene
CAS 2444540-01-4C18H15IS
2-(2-Fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene chemical structure, C18H14FIS, CAS 2436275-33-9
2-(2-Fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene
CAS 2436275-33-9C18H14FIS
2-(3-Fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene chemical structure, C18H14FIS, CAS 2436275-39-5
2-(3-Fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene
CAS 2436275-39-5C18H14FIS
2-(4-Fluorophenyl)-5-(3-iodo-2-methylbenzyl)thiophene chemical structure, C18H14FIS, CAS 2444540-10-5
2-(4-Fluorophenyl)-5-(3-iodo-2-methylbenzyl)thiophene
CAS 2444540-10-5C18H14FIS
Methyl 2-bromo-4-((5-(4-fluorophenyl)thiophen-2-yl)methyl)benzoate chemical structure, C19H14BrFO2S, CAS 1428730-81-7
Methyl 2-bromo-4-((5-(4-fluorophenyl)thiophen-2-yl)methyl)benzoate
CAS 1428730-81-7C19H14BrFO2S
2-Bromo-4-[[5-(4-fluorophenyl)-2-thienyl]methyl]benzenemethanol chemical structure, C18H14BrFOS, CAS 1428730-82-8
2-Bromo-4-[[5-(4-fluorophenyl)-2-thienyl]methyl]benzenemethanol
CAS 1428730-82-8C18H14BrFOS
(5-(4-Fluorophenyl)thiophen-2-yl)(5-iodo-2-methylphenyl)methanol chemical structure, C18H14FIOS, CAS 1818268-45-9
(5-(4-Fluorophenyl)thiophen-2-yl)(5-iodo-2-methylphenyl)methanol
CAS 1818268-45-9C18H14FIOS
3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylbenzoic acid chemical structure, C19H15FO2S, CAS 1956355-91-1
3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylbenzoic acid
CAS 1956355-91-1C19H15FO2S
D-Glucose, 1-C-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)- chemical structure, C24H25FO6S, CAS 1809403-04-0
D-Glucose, 1-C-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-
CAS 1809403-04-0C24H25FO6S
2-(4-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene chemical structure, C18H14BrFS, CAS 2265214-89-7
2-(4-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
CAS 2265214-89-7C18H14BrFS
(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)trimethylsilane chemical structure, C21H23FSSi, CAS 2639148-37-9
(3-((5-(4-Fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)trimethylsilane
CAS 2639148-37-9C21H23FSSi
alpha-(5-Bromo-2-methylphenyl)-5-(4-fluorophenyl)-2-thiophenemethanol chemical structure, C18H14BrFOS, CAS 1818268-44-8
alpha-(5-Bromo-2-methylphenyl)-5-(4-fluorophenyl)-2-thiophenemethanol
CAS 1818268-44-8C18H14BrFOS
(3-{[5-(4-Fluorophenyl)thiophen-2-yl]methyl}-4-methylphenyl)boronic acid chemical structure, C18H16BFO2S, CAS 2338840-85-8
(3-{[5-(4-Fluorophenyl)thiophen-2-yl]methyl}-4-methylphenyl)boronic acid
CAS 2338840-85-8C18H16BFO2S
Canagliflozin impurity 76 chemical structure, C18H14FIS, CAS 2952941-15-8
Canagliflozin impurity 76
CAS 2952941-15-8C18H14FIS
(E)-2-(5-(Buta-1,3-dien-1-yl)-2-methylbenzyl)-5-(4-fluorophenyl)thiophene chemical structure, C22H19FS, CAS 3041999-67-8
(E)-2-(5-(Buta-1,3-dien-1-yl)-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
CAS 3041999-67-8C22H19FS