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Murcko scaffold

Ring system with 3 rings and 18 atoms

22 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
22
With full pages
9
Scaffold SMILES

c1ccc(CSc2ncc3c(n2)CCCC3)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CSc2ncc3c(n2)CCCC3)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 22 of 22 chemicals

4-Methyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline chemical structure, C17H20N2S, CAS 689750-04-7
4-Methyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline
CAS 689750-04-7C17H20N2S
4-Methyl-2-[(3-nitrobenzyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline chemical structure, C16H17N3O2S, CAS 577786-85-7
4-Methyl-2-[(3-nitrobenzyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline
CAS 577786-85-7C16H17N3O2S
2-(Benzylsulfanyl)-4-methyl-5,6,7,8-tetrahydroquinazoline chemical structure, C16H18N2S, CAS 578721-53-6
2-(Benzylsulfanyl)-4-methyl-5,6,7,8-tetrahydroquinazoline
CAS 578721-53-6C16H18N2S
2-[(3-Chlorobenzyl)sulfanyl]-4-methyl-5,6,7,8-tetrahydroquinazoline chemical structure, C16H17ClN2S, CAS 587002-34-4
2-[(3-Chlorobenzyl)sulfanyl]-4-methyl-5,6,7,8-tetrahydroquinazoline
CAS 587002-34-4C16H17ClN2S
4-Chloro-2-[(2-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline chemical structure, C15H14Cl2N2S, CAS 338963-53-4
4-Chloro-2-[(2-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline
CAS 338963-53-4C15H14Cl2N2S
N-Isopropyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine chemical structure, C19H25N3S, CAS 338776-84-4
N-Isopropyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine
CAS 338776-84-4C19H25N3S
N-Methyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine chemical structure, C17H21N3S, CAS 338776-86-6
N-Methyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine
CAS 338776-86-6C17H21N3S
4-Chloro-2-[(4-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline chemical structure, C15H14Cl2N2S, CAS 338776-91-3
4-Chloro-2-[(4-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline
CAS 338776-91-3C15H14Cl2N2S
N-Ethyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine chemical structure, C18H23N3S, CAS 343373-56-8
N-Ethyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine
CAS 343373-56-8C18H23N3S
Methyl 2-({2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}sulfanyl)acetate chemical structure, C19H22N2O2S2, CAS 343374-11-8
Methyl 2-({2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}sulfanyl)acetate
CAS 343374-11-8C19H22N2O2S2
2-({2-[(4-Methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}sulfanyl)acetic acid chemical structure, C18H20N2O2S2, CAS 339018-80-3
2-({2-[(4-Methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}sulfanyl)acetic acid
CAS 339018-80-3C18H20N2O2S2
N-{2-[(2-Chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}-N-methylamine chemical structure, C16H18ClN3S, CAS 339019-32-8
N-{2-[(2-Chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}-N-methylamine
CAS 339019-32-8C16H18ClN3S
Methyl 2-({2-[(2-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}sulfanyl)acetate chemical structure, C18H19ClN2O2S2, CAS 339019-38-4
Methyl 2-({2-[(2-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}sulfanyl)acetate
CAS 339019-38-4C18H19ClN2O2S2
N-{2-[(2-Chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}-N,N-dimethylamine chemical structure, C17H20ClN3S, CAS 478246-71-8
N-{2-[(2-Chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}-N,N-dimethylamine
CAS 478246-71-8C17H20ClN3S
N-{2-[(4-Chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}-N,N-dimethylamine chemical structure, C17H20ClN3S, CAS 478246-72-9
N-{2-[(4-Chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}-N,N-dimethylamine
CAS 478246-72-9C17H20ClN3S
N,N-Dimethyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine chemical structure, C18H23N3S, CAS 338776-87-7
N,N-Dimethyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine
CAS 338776-87-7C18H23N3S
N-Allyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine chemical structure, C19H23N3S, CAS 338776-75-3
N-Allyl-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine
CAS 338776-75-3C19H23N3S
4-Chloro-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline chemical structure, C16H17ClN2S, CAS 338963-39-6
4-Chloro-2-[(4-methylbenzyl)sulfanyl]-5,6,7,8-tetrahydroquinazoline
CAS 338963-39-6C16H17ClN2S
N-Allyl-2-[(2-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine chemical structure, C18H20ClN3S, CAS 339019-33-9
N-Allyl-2-[(2-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine
CAS 339019-33-9C18H20ClN3S
tert-Butyl 2-[(4-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl sulfide chemical structure, C19H23ClN2S2, CAS 339019-15-7
tert-Butyl 2-[(4-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl sulfide
CAS 339019-15-7C19H23ClN2S2
N-Allyl-2-[(4-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine chemical structure, C18H20ClN3S, CAS 339019-11-3
N-Allyl-2-[(4-chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinamine
CAS 339019-11-3C18H20ClN3S
2-({2-[(2-Chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}sulfanyl)acetic acid chemical structure, C17H17ClN2O2S2, CAS 339019-39-5
2-({2-[(2-Chlorobenzyl)sulfanyl]-5,6,7,8-tetrahydro-4-quinazolinyl}sulfanyl)acetic acid
CAS 339019-39-5C17H17ClN2O2S2