Murcko scaffold
N'-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)benzohydrazide scaffold
91 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 23
- Chemicals
- 91
- With full pages
- 4
Scaffold SMILES
O=C(NNC1CC(=O)N(c2ccccc2)C1=O)c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 91 chemicals
![N'-[1-(2-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide chemical structure, C17H14ClN3O3, CAS 496941-65-2](/s/UELDDNXZCLTEEA-UHFFFAOYSA-N.svg)
N'-[1-(2-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide
CAS 496941-65-2C17H14ClN3O3
N'-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)benzohydrazide
CAS 111420-95-2C17H15N3O3
![4-(Dimethylamino)-N'-[1-(4-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide chemical structure, C19H19FN4O3, CAS 956203-76-2](/s/OGZBCZOOVZHMCW-UHFFFAOYSA-N.svg)
4-(Dimethylamino)-N'-[1-(4-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide
CAS 956203-76-2C19H19FN4O3
![Dimethyl 5-{3-[2-(2-bromobenzoyl)hydrazino]-2,5-dioxo-1-pyrrolidinyl}isophthalate chemical structure, C21H18BrN3O7, CAS 956203-49-9](/s/YHBURLVXPOKIJS-UHFFFAOYSA-N.svg)
Dimethyl 5-{3-[2-(2-bromobenzoyl)hydrazino]-2,5-dioxo-1-pyrrolidinyl}isophthalate
CAS 956203-49-9C21H18BrN3O7
![2-Bromo-N'-[1-(2-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide chemical structure, C17H13BrFN3O3, CAS 957038-06-1](/s/XAJBNTGJLMBWNV-UHFFFAOYSA-N.svg)
2-Bromo-N'-[1-(2-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide
CAS 957038-06-1C17H13BrFN3O3
![N'-Acetyl-2-chloro-N'-[1-(4-methylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide chemical structure, C20H18ClN3O4, CAS 956202-37-2](/s/SAGKLNSSYNPQDW-UHFFFAOYSA-N.svg)
N'-Acetyl-2-chloro-N'-[1-(4-methylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide
CAS 956202-37-2C20H18ClN3O4
![N'-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-2-methylbenzohydrazide chemical structure, C18H16BrN3O3, CAS 485394-63-6](/s/QHNUVQDQZWQWEJ-UHFFFAOYSA-N.svg)
N'-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-2-methylbenzohydrazide
CAS 485394-63-6C18H16BrN3O3
![N'-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-3-methylbenzohydrazide chemical structure, C18H16BrN3O3, CAS 485394-64-7](/s/RADGCEDQONHTFI-UHFFFAOYSA-N.svg)
N'-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-3-methylbenzohydrazide
CAS 485394-64-7C18H16BrN3O3
![N'-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-4-methylbenzohydrazide chemical structure, C18H16BrN3O3, CAS 485394-65-8](/s/IYXJDZLDYZMOBQ-UHFFFAOYSA-N.svg)
N'-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-4-methylbenzohydrazide
CAS 485394-65-8C18H16BrN3O3
![N'-[1-(4-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-2-methylbenzohydrazide chemical structure, C18H16ClN3O3, CAS 485394-86-3](/s/AZQCSTSZZKRLNE-UHFFFAOYSA-N.svg)
N'-[1-(4-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-2-methylbenzohydrazide
CAS 485394-86-3C18H16ClN3O3
![N'-[1-(4-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-3-methylbenzohydrazide chemical structure, C18H16ClN3O3, CAS 485394-87-4](/s/SEMUVSDFMYHXIE-UHFFFAOYSA-N.svg)
N'-[1-(4-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-3-methylbenzohydrazide
CAS 485394-87-4C18H16ClN3O3
![N'-[1-(4-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-methylbenzohydrazide chemical structure, C18H16ClN3O3, CAS 485394-88-5](/s/CUICXMWCGWEPOI-UHFFFAOYSA-N.svg)
N'-[1-(4-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-4-methylbenzohydrazide
CAS 485394-88-5C18H16ClN3O3
![4-Chloro-N'-[1-(3,5-dimethylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide chemical structure, C19H18ClN3O3, CAS 956779-70-7](/s/LDEISLQNJQCYJJ-UHFFFAOYSA-N.svg)
4-Chloro-N'-[1-(3,5-dimethylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide
CAS 956779-70-7C19H18ClN3O3
![N'-[1-(2,4-Dimethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-methylbenzohydrazide chemical structure, C20H21N3O5, CAS 956755-64-9](/s/HIZVHOLNTGDTKM-UHFFFAOYSA-N.svg)
N'-[1-(2,4-Dimethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-4-methylbenzohydrazide
CAS 956755-64-9C20H21N3O5
Dimethyl 5-(3-(2-((2,4-dichlorophenyl)carbonyl)hydrazino)-2,5-dioxo-1-pyrrolidinyl)-1,3-benzenedicarboxylate
CAS 956779-75-2C21H17Cl2N3O7
![N'-[1-(3,5-Dichlorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide chemical structure, C17H13Cl2N3O3, CAS 367927-88-6](/s/KRNBJSREVFVVBO-UHFFFAOYSA-N.svg)
N'-[1-(3,5-Dichlorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide
CAS 367927-88-6C17H13Cl2N3O3
N'-(1-(4-(1-Methylethyl)phenyl)-2,5-dioxo-3-pyrrolidinyl)benzohydrazide
CAS 956753-81-4C20H21N3O3
![2-Chloro-N'-[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide chemical structure, C18H16ClN3O4, CAS 956753-67-6](/s/YLPMXKCWTKWKHK-UHFFFAOYSA-N.svg)
2-Chloro-N'-[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide
CAS 956753-67-6C18H16ClN3O4
![2-Chloro-N'-{2,5-dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}benzohydrazide chemical structure, C18H13ClF3N3O3, CAS 956960-39-7](/s/MJGSZPZTKKMDFU-UHFFFAOYSA-N.svg)
2-Chloro-N'-{2,5-dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}benzohydrazide
CAS 956960-39-7C18H13ClF3N3O3
Dimethyl 5-(3-(2-((2-chlorophenyl)carbonyl)hydrazino)-2,5-dioxo-1-pyrrolidinyl)-1,3-benzenedicarboxylate
CAS 956755-37-6C21H18ClN3O7
![N'-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-2-nitrobenzohydrazide chemical structure, C17H13FN4O5, CAS 956754-09-9](/s/LRTQTUZJKXMKBO-UHFFFAOYSA-N.svg)
N'-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-2-nitrobenzohydrazide
CAS 956754-09-9C17H13FN4O5
![N'-{2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}-3,4,5-trimethoxybenzohydrazide chemical structure, C21H20F3N3O6, CAS 956204-35-6](/s/OQKVNNQWVDLLBZ-UHFFFAOYSA-N.svg)
N'-{2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}-3,4,5-trimethoxybenzohydrazide
CAS 956204-35-6C21H20F3N3O6
![3,4,5-Trimethoxy-N'-[1-(5-methoxy-2-methylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide chemical structure, C22H25N3O7, CAS 956779-86-5](/s/XLQAOFWXTKRZNB-UHFFFAOYSA-N.svg)
3,4,5-Trimethoxy-N'-[1-(5-methoxy-2-methylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide
CAS 956779-86-5C22H25N3O7
![2-Bromo-N'-[1-(4-methylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide chemical structure, C18H16BrN3O3, CAS 487001-77-4](/s/HWIQMLRVQVPMDN-UHFFFAOYSA-N.svg)
2-Bromo-N'-[1-(4-methylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide
CAS 487001-77-4C18H16BrN3O3
- Ethyl 4-{2,5-dioxo-3-[2-(3,4,5-trimethoxybenzoyl)hydrazino]-1-pyrrolidinyl}benzoate956763-50-1C23H25N3O8
- 3-Chloro-N'-[1-(3-methylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide956612-31-0C18H16ClN3O3
- 3-Chloro-N'-[1-(2,3-dichlorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide956612-70-7C17H12Cl3N3O3
- N'-[1-(4-Chloro-3-methylphenyl)-2,5-dioxopyrrolidin-3-yl]-4-methylbenzohydrazide956204-08-3C19H18ClN3O3
- 2-Chloro-N'-{2,5-dioxo-1-[4-(propan-2-yl)phenyl]pyrrolidin-3-yl}benzohydrazide956741-71-2C20H20ClN3O3
- 3,4,5-Trimethoxy-N'-[1-(3-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-N'-propanoylbenzohydrazide956370-87-9C24H27N3O8
- N'-{2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}-N'-propanoylbenzohydrazide956441-72-8C21H18F3N3O4
- N'-[1-(3-Methylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide956369-44-1C18H17N3O3
- Ethyl 4-{2,5-dioxo-3-[(phenylcarbonylamino)amino]azolidinyl}benzoate667404-25-3C20H19N3O5
- Dimethyl 5-{3-[2-(4-methylbenzoyl)hydrazino]-2,5-dioxo-1-pyrrolidinyl}isophthalate956394-45-9C22H21N3O7
- N'-[1-(3-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide519168-78-6C18H17N3O4
- 3-Chloro-N'-[1-(2,5-dimethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide956206-37-4C19H18ClN3O5
- 3-Chloro-N'-[1-(4-methylphenyl)-2,5-dioxopyrrolidin-3-yl]-N'-(2-methylpropanoyl)benzohydrazide956262-30-9C22H22ClN3O4
- N'-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)-3,4,5-trimethoxybenzohydrazide956264-33-8C20H21N3O6
- N'-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide956368-39-1C17H14FN3O3
- N'-{2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}benzohydrazide667404-26-4C18H14F3N3O3
- 2-Chloro-N'-[1-(4-fluorophenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide956977-36-9C17H13ClFN3O3
- N'-[1-(4-Ethylphenyl)-2,5-dioxopyrrolidin-3-yl]-3,4,5-trimethoxybenzohydrazide956206-52-3C22H25N3O6
- 2-Chloro-N'-[1-(2-ethylphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide956625-43-7C19H18ClN3O3
- N'-[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide360784-29-8C18H17N3O4
- N'-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)-4-methyl-N'-(2-methylpropanoyl)benzohydrazide956441-19-3C22H23N3O4
- N'-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-3,4,5-trimethoxybenzohydrazide956780-03-3C20H20FN3O6
- N'-[1-(2,4-Dimethylphenyl)-2,5-dioxopyrrolidin-3-yl]-3,4,5-trimethoxybenzohydrazide956183-45-2C22H25N3O6
- 2-Bromo-N'-[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]benzohydrazide956795-07-6C18H16BrN3O4
Related scaffolds
Same ring framework with different atoms or bond orders
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O=C(CSc1nnc(-c2ccccc2)o1)N1CCCCC127 chemicals
O=C(C=Cc1ccc(-c2ccccc2)o1)c1ccccc117 chemicals
O=C(Cc1ccccc1)Nc1nc(-c2ccccc2)cs115 chemicals
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C(=NNc1nc(-c2ccccc2)cs1)c1ccccc112 chemicals
O=S(=O)(NCc1nc(-c2ccccc2)no1)c1ccccc111 chemicals![Scaffold O=C(Nc1ccccc1)Nc1c[nH]n(-c2ccccc2)c1=O](/scaffold/QSSZUVFMHJMXDP-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)Nc1c[nH]n(-c2ccccc2)c1=O11 chemicals
O=C(Cc1ccccc1)Nc1nnc(-c2ccccc2)o111 chemicals![Scaffold O=C(CSc1nnc(-c2ccccc2)[nH]1)c1ccccc1](/scaffold/DLNCASBDPGAELF-UHFFFAOYSA-N/structure.svg)
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O=c1n(-c2ccccc2)cnn1CCOc1ccccc110 chemicals