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Murcko scaffold

Ring system with 3 rings and 18 atoms

65 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
65
With full pages
4
Scaffold SMILES

O=C1C(C=Nc2ccccc2)=Cc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1C(C=Nc2ccccc2)=Cc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 65 chemicals

(E)-3-Hydroxy-2-(1-((2-methyl-5-nitrophenyl)imino)ethyl)-1H-inden-1-one chemical structure, C18H14N2O4, CAS 325985-69-1
(E)-3-Hydroxy-2-(1-((2-methyl-5-nitrophenyl)imino)ethyl)-1H-inden-1-one
CAS 325985-69-1C18H14N2O4
2-(1,3-Dioxoindan-2-ylidene)-2-((2-chlorophenyl)amino)ethanenitrile chemical structure, C17H9ClN2O2, CAS 685550-68-9
2-(1,3-Dioxoindan-2-ylidene)-2-((2-chlorophenyl)amino)ethanenitrile
CAS 685550-68-9C17H9ClN2O2
2-(1,3-Dioxoindan-2-ylidene)-2-((2-chloro-6-methylphenyl)amino)ethanenitrile chemical structure, C18H11ClN2O2, CAS 1023883-24-0
2-(1,3-Dioxoindan-2-ylidene)-2-((2-chloro-6-methylphenyl)amino)ethanenitrile
CAS 1023883-24-0C18H11ClN2O2
2-{[(4-Nitrophenyl)amino]methylidene}-2,3-dihydro-1H-indene-1,3-dione chemical structure, C16H10N2O4, CAS 40462-01-9
2-{[(4-Nitrophenyl)amino]methylidene}-2,3-dihydro-1H-indene-1,3-dione
CAS 40462-01-9C16H10N2O4
2-[(2-Methoxy-4-nitroanilino)methylene]-1H-indene-1,3(2H)-dione chemical structure, C17H12N2O5, CAS 5789-41-3
2-[(2-Methoxy-4-nitroanilino)methylene]-1H-indene-1,3(2H)-dione
CAS 5789-41-3C17H12N2O5
Methyl 4-{[(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl]amino}benzoate chemical structure, C18H13NO4, CAS 300808-83-7
Methyl 4-{[(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl]amino}benzoate
CAS 300808-83-7C18H13NO4
2-(((4-(Trifluoromethyl)phenyl)amino)methylene)indane-1,3-dione chemical structure, C17H10F3NO2, CAS 6476-24-0
2-(((4-(Trifluoromethyl)phenyl)amino)methylene)indane-1,3-dione
CAS 6476-24-0C17H10F3NO2
2-(((2-Nitro-5-(trifluoromethyl)phenyl)amino)methylene)indane-1,3-dione chemical structure, C17H9F3N2O4, CAS 1023502-21-7
2-(((2-Nitro-5-(trifluoromethyl)phenyl)amino)methylene)indane-1,3-dione
CAS 1023502-21-7C17H9F3N2O4
1H-Indene-1,3(2H)-dione, 2-((phenylamino)methylene)- chemical structure, C16H11NO2, CAS 38337-19-8
1H-Indene-1,3(2H)-dione, 2-((phenylamino)methylene)-
CAS 38337-19-8C16H11NO2
3-(((1,3-Dioxoindan-2-ylidene)methyl)amino)-4-chlorobenzoic acid chemical structure, C17H10ClNO4, CAS 1024375-27-6
3-(((1,3-Dioxoindan-2-ylidene)methyl)amino)-4-chlorobenzoic acid
CAS 1024375-27-6C17H10ClNO4
N-(4-(((1,3-Dioxoindan-2-ylidene)methyl)amino)phenyl)ethanamide chemical structure, C18H14N2O3, CAS 134828-25-4
N-(4-(((1,3-Dioxoindan-2-ylidene)methyl)amino)phenyl)ethanamide
CAS 134828-25-4C18H14N2O3
3-(((1,3-Dioxoindan-2-ylidene)methyl)amino)benzamide chemical structure, C17H12N2O3, CAS 1022652-51-2
3-(((1,3-Dioxoindan-2-ylidene)methyl)amino)benzamide
CAS 1022652-51-2C17H12N2O3
2-(((2,5-Dimethoxyphenyl)amino)methylene)indane-1,3-dione chemical structure, C18H15NO4, CAS 1020252-29-2
2-(((2,5-Dimethoxyphenyl)amino)methylene)indane-1,3-dione
CAS 1020252-29-2C18H15NO4
1H-Indene-1,3(2H)-dione, 2-[[(4-methoxyphenyl)amino]methylene]- chemical structure, C17H13NO3, CAS 38756-21-7
1H-Indene-1,3(2H)-dione, 2-[[(4-methoxyphenyl)amino]methylene]-
CAS 38756-21-7C17H13NO3
2-(1,3-Dioxoindan-2-ylidene)-2-((3-(1,1,2,2-tetrafluoroethoxy)phenyl)amino)ethanenitrile chemical structure, C19H10F4N2O3, CAS 1022404-19-8
2-(1,3-Dioxoindan-2-ylidene)-2-((3-(1,1,2,2-tetrafluoroethoxy)phenyl)amino)ethanenitrile
CAS 1022404-19-8C19H10F4N2O3
1H-Indene-1,3(2H)-dione, 2-[[(methylphenyl)amino]methylene]- chemical structure, C17H13NO2, CAS 113006-67-0
1H-Indene-1,3(2H)-dione, 2-[[(methylphenyl)amino]methylene]-
CAS 113006-67-0C17H13NO2
2-(((4-Fluorophenyl)amino)ethylidene)indane-1,3-dione chemical structure, C17H12FNO2, CAS 59876-60-7
2-(((4-Fluorophenyl)amino)ethylidene)indane-1,3-dione
CAS 59876-60-7C17H12FNO2
2-{[2-Chloro-5-(trifluoromethyl)anilino]methylene}-1H-indene-1,3(2H)-dione chemical structure, C17H9ClF3NO2, CAS 1020252-62-3
2-{[2-Chloro-5-(trifluoromethyl)anilino]methylene}-1H-indene-1,3(2H)-dione
CAS 1020252-62-3C17H9ClF3NO2
Dimethyl 5-{[1-(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)ethyl]amino}benzene-1,3-dicarboxylate chemical structure, C21H17NO6, CAS 586998-28-9
Dimethyl 5-{[1-(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)ethyl]amino}benzene-1,3-dicarboxylate
CAS 586998-28-9C21H17NO6
Methyl 5-(((1,3-dioxoindan-2-ylidene)methyl)amino)-3-(methoxycarbonyl)benzoate chemical structure, C20H15NO6, CAS 432530-68-2
Methyl 5-(((1,3-dioxoindan-2-ylidene)methyl)amino)-3-(methoxycarbonyl)benzoate
CAS 432530-68-2C20H15NO6
2-(((4-(2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)amino)ethylidene)indane-1,3-dione chemical structure, C20H13F6NO3, CAS 1024227-89-1
2-(((4-(2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)amino)ethylidene)indane-1,3-dione
CAS 1024227-89-1C20H13F6NO3
2-({[3,5-Bis(trifluoromethyl)phenyl]amino}methylidene)-1H-indene-1,3(2H)-dione chemical structure, C18H9F6NO2, CAS 375835-84-0
2-({[3,5-Bis(trifluoromethyl)phenyl]amino}methylidene)-1H-indene-1,3(2H)-dione
CAS 375835-84-0C18H9F6NO2
(4-Chloroanilino)(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)acetonitrile chemical structure, C17H9ClN2O2, CAS 38756-09-1
(4-Chloroanilino)(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)acetonitrile
CAS 38756-09-1C17H9ClN2O2
2-((2,5-Dimethoxyphenyl)amino)-2-(1,3-dioxoindan-2-ylidene)ethanenitrile chemical structure, C19H14N2O4, CAS 685550-63-4
2-((2,5-Dimethoxyphenyl)amino)-2-(1,3-dioxoindan-2-ylidene)ethanenitrile
CAS 685550-63-4C19H14N2O4