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Murcko scaffold

1-Benzyl-5-phenyl-1,5-dihydro-2H-pyrrol-2-one scaffold

16 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
16
With full pages
7
Scaffold SMILES

O=C1C=CC(c2ccccc2)N1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzyl-5-phenyl-1,5-dihydro-2H-pyrrol-2-one page
Murcko scaffold O=C1C=CC(c2ccccc2)N1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 16 of 16 chemicals

3-Acetyl-1-benzyl-4-hydroxy-2-(3-nitrophenyl)-2H-pyrrol-5-one chemical structure, C19H16N2O5, CAS 296797-87-0
3-Acetyl-1-benzyl-4-hydroxy-2-(3-nitrophenyl)-2H-pyrrol-5-one
CAS 296797-87-0C19H16N2O5
4-Acetyl-1-benzyl-3-hydroxy-5-phenyl-1,5-dihydro-2H-pyrrol-2-one chemical structure, C19H17NO3, CAS 331751-42-9
4-Acetyl-1-benzyl-3-hydroxy-5-phenyl-1,5-dihydro-2H-pyrrol-2-one
CAS 331751-42-9C19H17NO3
3-Acetyl-1-benzyl-4-hydroxy-2-(4-nitrophenyl)-2H-pyrrol-5-one chemical structure, C19H16N2O5, CAS 311321-11-6
3-Acetyl-1-benzyl-4-hydroxy-2-(4-nitrophenyl)-2H-pyrrol-5-one
CAS 311321-11-6C19H16N2O5
3-Acetyl-1-benzyl-4-hydroxy-2-(4-methoxyphenyl)-2H-pyrrol-5-one chemical structure, C20H19NO4, CAS 339218-58-5
3-Acetyl-1-benzyl-4-hydroxy-2-(4-methoxyphenyl)-2H-pyrrol-5-one
CAS 339218-58-5C20H19NO4
4-Acetyl-1-benzyl-5-(3,4-dimethoxyphenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H21NO5, CAS 339310-85-9
4-Acetyl-1-benzyl-5-(3,4-dimethoxyphenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
CAS 339310-85-9C21H21NO5
4-Acetyl-1-benzyl-5-[4-(dimethylamino)phenyl]-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one chemical structure, C21H22N2O3, CAS 296771-66-9
4-Acetyl-1-benzyl-5-[4-(dimethylamino)phenyl]-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
CAS 296771-66-9C21H22N2O3
3-Acetyl-1-benzyl-2-(2,4-dimethoxyphenyl)-4-hydroxy-2H-pyrrol-5-one chemical structure, C21H21NO5, CAS 370582-67-5
3-Acetyl-1-benzyl-2-(2,4-dimethoxyphenyl)-4-hydroxy-2H-pyrrol-5-one
CAS 370582-67-5C21H21NO5
4-Acetyl-1-benzyl-5-(2-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one chemical structure, C19H16FNO3, CAS 312502-03-7
4-Acetyl-1-benzyl-5-(2-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
CAS 312502-03-7C19H16FNO3
4-Acetyl-1-benzyl-5-(4-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one chemical structure, C19H16FNO3, CAS 309266-26-0
4-Acetyl-1-benzyl-5-(4-fluorophenyl)-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one
CAS 309266-26-0C19H16FNO3
1-Benzyl-3-(1-ethylsulfanyl-2,2,2-trifluoroethyl)-5-hydroxy-5-phenylpyrrol-2-one chemical structure, C21H20F3NO2S, CAS 7232-02-2
1-Benzyl-3-(1-ethylsulfanyl-2,2,2-trifluoroethyl)-5-hydroxy-5-phenylpyrrol-2-one
CAS 7232-02-2C21H20F3NO2S
3-Acetyl-4-hydroxy-5-oxo-2-phenyl-1-(phenylethyl)-3-pyrroline chemical structure, C20H19NO3, CAS 1017632-43-7
3-Acetyl-4-hydroxy-5-oxo-2-phenyl-1-(phenylethyl)-3-pyrroline
CAS 1017632-43-7C20H19NO3
1-Benzyl-5-(4-bromophenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C17H14BrNO, CAS 824935-57-1
1-Benzyl-5-(4-bromophenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 824935-57-1C17H14BrNO
1-Benzyl-5-(4-methylphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C18H17NO, CAS 824935-56-0
1-Benzyl-5-(4-methylphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 824935-56-0C18H17NO
1-Benzyl-5-(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one chemical structure, C18H17NO2, CAS 824935-55-9
1-Benzyl-5-(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one
CAS 824935-55-9C18H17NO2
1-Benzyl-5-phenyl-1,5-dihydro-2H-pyrrol-2-one chemical structure, C17H15NO, CAS 824935-47-9
1-Benzyl-5-phenyl-1,5-dihydro-2H-pyrrol-2-one
CAS 824935-47-9C17H15NO
4-Acetyl-5-(4-chlorophenyl)-3-hydroxy-1-[(4-methoxyphenyl)methyl]-2,5-dihydro-1H-pyrrol-2-one chemical structure, C20H18ClNO4, CAS 1639116-07-6
4-Acetyl-5-(4-chlorophenyl)-3-hydroxy-1-[(4-methoxyphenyl)methyl]-2,5-dihydro-1H-pyrrol-2-one
CAS 1639116-07-6C20H18ClNO4