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Murcko scaffold

Ring system with 3 rings and 22 atoms

35 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
35
With full pages
8
Scaffold SMILES

O=C(CSc1nnc(-c2ccccc2)o1)NC1CCCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(-c2ccccc2)o1)NC1CCCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 35 of 35 chemicals

N-Cyclohexyl-2-(5-o-tolyl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetamide chemical structure, C17H21N3O2S, CAS 484694-94-2
N-Cyclohexyl-2-(5-o-tolyl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetamide
CAS 484694-94-2C17H21N3O2S
N-Cyclohexyl-2-{[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C17H21N3O3S, CAS 340818-49-7
N-Cyclohexyl-2-{[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 340818-49-7C17H21N3O3S
N-Cyclohexyl-2-{[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C17H21N3O2S, CAS 335215-54-8
N-Cyclohexyl-2-{[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 335215-54-8C17H21N3O2S
N-Cyclohexyl-2-{[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C16H18FN3O2S, CAS 459846-31-2
N-Cyclohexyl-2-{[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 459846-31-2C16H18FN3O2S
N-Cyclohexyl-2-{[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C17H21N3O2S, CAS 461001-01-4
N-Cyclohexyl-2-{[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 461001-01-4C17H21N3O2S
N-Cyclohexyl-2-{[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C16H18FN3O2S, CAS 459861-04-2
N-Cyclohexyl-2-{[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 459861-04-2C16H18FN3O2S
N-Cyclohexyl-2-{[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C18H23N3O2S, CAS 850471-74-8
N-Cyclohexyl-2-{[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 850471-74-8C18H23N3O2S
N-Cyclohexyl-2-{[5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C18H23N3O4S, CAS 460728-13-6
N-Cyclohexyl-2-{[5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 460728-13-6C18H23N3O4S
2-{[5-(3-Chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-cyclohexylacetamide chemical structure, C16H18ClN3O2S, CAS 797810-70-9
2-{[5-(3-Chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-cyclohexylacetamide
CAS 797810-70-9C16H18ClN3O2S
N-Cyclohexyl-2-((5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamide chemical structure, C18H23N3O4S, CAS 486398-00-9
N-Cyclohexyl-2-((5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamide
CAS 486398-00-9C18H23N3O4S
2-[[5-(3-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-cyclohexylacetamide chemical structure, C16H18BrN3O2S, CAS 827012-29-3
2-[[5-(3-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-cyclohexylacetamide
CAS 827012-29-3C16H18BrN3O2S
N-Cyclohexyl-2-[[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide chemical structure, C17H21N3O3S, CAS 850936-88-8
N-Cyclohexyl-2-[[5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
CAS 850936-88-8C17H21N3O3S
N-Cyclohexyl-2-{[5-(3-methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C17H21N3O3S, CAS 484695-61-6
N-Cyclohexyl-2-{[5-(3-methoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 484695-61-6C17H21N3O3S
N-Cyclohexyl-2-{[5-(4-ethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C18H23N3O3S, CAS 850937-18-7
N-Cyclohexyl-2-{[5-(4-ethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 850937-18-7C18H23N3O3S
N-Cyclohexyl-2-{[5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C19H25N3O5S, CAS 444151-45-5
N-Cyclohexyl-2-{[5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 444151-45-5C19H25N3O5S
N-Cyclohexyl-2-{[5-(2,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C18H23N3O4S, CAS 851129-68-5
N-Cyclohexyl-2-{[5-(2,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 851129-68-5C18H23N3O4S
2-{[5-(4-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-cyclohexylacetamide chemical structure, C16H18BrN3O2S, CAS 332161-64-5
2-{[5-(4-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-cyclohexylacetamide
CAS 332161-64-5C16H18BrN3O2S
N-(2-Methylcyclohexyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide chemical structure, C17H21N3O2S, CAS 591765-10-5
N-(2-Methylcyclohexyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
CAS 591765-10-5C17H21N3O2S
2-{[5-(4-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(2-methylcyclohexyl)acetamide chemical structure, C17H20BrN3O2S, CAS 693241-13-3
2-{[5-(4-Bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-(2-methylcyclohexyl)acetamide
CAS 693241-13-3C17H20BrN3O2S
N-Cyclohexyl-2-[[5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide chemical structure, C16H19N3O3S, CAS 883276-16-2
N-Cyclohexyl-2-[[5-(3-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
CAS 883276-16-2C16H19N3O3S
2-((5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(1-cyanocyclohexyl)-N-methylacetamide chemical structure, C18H19ClN4O2S, CAS 854136-39-3
2-((5-(4-Chlorophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(1-cyanocyclohexyl)-N-methylacetamide
CAS 854136-39-3C18H19ClN4O2S
N-(1-Cyanocyclohexyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide chemical structure, C17H18N4O2S, CAS 850335-86-3
N-(1-Cyanocyclohexyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
CAS 850335-86-3C17H18N4O2S
N-(1-Cyanocyclohexyl)-2-{[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide chemical structure, C17H17FN4O2S, CAS 931636-93-0
N-(1-Cyanocyclohexyl)-2-{[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
CAS 931636-93-0C17H17FN4O2S
N-(1-Cyanocyclohexyl)-2-{[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-methylacetamide chemical structure, C18H19FN4O2S, CAS 903798-01-6
N-(1-Cyanocyclohexyl)-2-{[5-(2-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-N-methylacetamide
CAS 903798-01-6C18H19FN4O2S