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Murcko scaffold

Ring system with 3 rings and 16 atoms

37 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
37
With full pages
7
Scaffold SMILES

O=C1CC(c2ccccc2)Cc2[nH]ccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)Cc2[nH]ccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 37 of 37 chemicals

Methyl 6-(4-chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C17H16ClNO3, CAS 27463-39-4
Methyl 6-(4-chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 27463-39-4C17H16ClNO3
6-(4-Chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid chemical structure, C16H14ClNO3, CAS 702665-70-1
6-(4-Chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid
CAS 702665-70-1C16H14ClNO3
Methyl 3-methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C17H17NO3, CAS 27398-74-9
Methyl 3-methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 27398-74-9C17H17NO3
Methyl 6-(4-tert-butylphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C21H25NO3, CAS 717827-79-7
Methyl 6-(4-tert-butylphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 717827-79-7C21H25NO3
Ethyl 4-oxo-6-phenyl-3-propyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C20H23NO3, CAS 27398-81-8
Ethyl 4-oxo-6-phenyl-3-propyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 27398-81-8C20H23NO3
Ethyl 6-(2,5-dimethoxyphenyl)-4-oxo-3-propyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C22H27NO5, CAS 717829-86-2
Ethyl 6-(2,5-dimethoxyphenyl)-4-oxo-3-propyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 717829-86-2C22H27NO5
6-(4-Methoxyphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid chemical structure, C17H17NO4, CAS 833430-21-0
6-(4-Methoxyphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid
CAS 833430-21-0C17H17NO4
Ethyl 6-(3,4-dimethoxyphenyl)-4-oxo-3-propyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C22H27NO5, CAS 833439-43-3
Ethyl 6-(3,4-dimethoxyphenyl)-4-oxo-3-propyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 833439-43-3C22H27NO5
Propan-2-yl 6-(2-chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C19H20ClNO3, CAS 835895-60-8
Propan-2-yl 6-(2-chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 835895-60-8C19H20ClNO3
Ethyl 6-(4-fluorophenyl)-4-oxo-3-propyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C20H22FNO3, CAS 836665-95-3
Ethyl 6-(4-fluorophenyl)-4-oxo-3-propyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 836665-95-3C20H22FNO3
Methyl 6-(4-ethylphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C19H21NO3, CAS 838380-55-5
Methyl 6-(4-ethylphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 838380-55-5C19H21NO3
6-(2-Chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid chemical structure, C16H14ClNO3, CAS 838870-79-4
6-(2-Chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylic acid
CAS 838870-79-4C16H14ClNO3
Propan-2-yl 6-[4-(dimethylamino)phenyl]-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C21H26N2O3, CAS 847465-66-1
Propan-2-yl 6-[4-(dimethylamino)phenyl]-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 847465-66-1C21H26N2O3
Prop-2-en-1-yl 6-[4-(dimethylamino)phenyl]-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C21H24N2O3, CAS 847465-13-8
Prop-2-en-1-yl 6-[4-(dimethylamino)phenyl]-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 847465-13-8C21H24N2O3
Ethyl 6-(3,4-dimethoxyphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C20H23NO5, CAS 725687-34-3
Ethyl 6-(3,4-dimethoxyphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 725687-34-3C20H23NO5
Ethyl 6-(4-ethoxy-3-methoxyphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C21H25NO5, CAS 725687-31-0
Ethyl 6-(4-ethoxy-3-methoxyphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 725687-31-0C21H25NO5
2-Propoxyethyl 6-(4-fluorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C21H24FNO4, CAS 695194-92-4
2-Propoxyethyl 6-(4-fluorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 695194-92-4C21H24FNO4
Ethyl 6-(3-methoxyphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C19H21NO4, CAS 27462-92-6
Ethyl 6-(3-methoxyphenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 27462-92-6C19H21NO4
Ethyl 6-(2-chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C18H18ClNO3, CAS 725687-53-6
Ethyl 6-(2-chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 725687-53-6C18H18ClNO3
Ethyl 3-methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C18H19NO3, CAS 27398-61-4
Ethyl 3-methyl-4-oxo-6-phenyl-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 27398-61-4C18H19NO3
Propan-2-yl 6-(4-chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C19H20ClNO3, CAS 725687-39-8
Propan-2-yl 6-(4-chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 725687-39-8C19H20ClNO3
Prop-2-en-1-yl 3-methyl-4-oxo-6-(3,4,5-trimethoxyphenyl)-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C22H25NO6, CAS 847463-91-6
Prop-2-en-1-yl 3-methyl-4-oxo-6-(3,4,5-trimethoxyphenyl)-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 847463-91-6C22H25NO6
2-(Propan-2-yloxy)ethyl 3-methyl-4-oxo-6-(3,4,5-trimethoxyphenyl)-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C24H31NO7, CAS 847463-87-0
2-(Propan-2-yloxy)ethyl 3-methyl-4-oxo-6-(3,4,5-trimethoxyphenyl)-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 847463-87-0C24H31NO7
Butan-2-yl 6-(4-chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate chemical structure, C20H22ClNO3, CAS 725687-42-3
Butan-2-yl 6-(4-chlorophenyl)-3-methyl-4-oxo-4,5,6,7-tetrahydro-1H-indole-2-carboxylate
CAS 725687-42-3C20H22ClNO3