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Murcko scaffold

4-Phenyl-1,2,3,4-tetrahydro-isoquinoline scaffold

112 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
112
With full pages
18
Scaffold SMILES

c1ccc(C2CNCc3ccccc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenyl-1,2,3,4-tetrahydro-isoquinoline page
Murcko scaffold c1ccc(C2CNCc3ccccc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 112 chemicals

Nomifensine chemical structure, C16H18N2, CAS 24526-64-5
Nomifensine
CAS 24526-64-5C16H18N2
Isoquinoline, 1,2,3,4-tetrahydro-4-phenyl-2,3,8-trimethyl-, (E)- chemical structure, C18H21N, CAS 40830-61-3
Isoquinoline, 1,2,3,4-tetrahydro-4-phenyl-2,3,8-trimethyl-, (E)-
CAS 40830-61-3C18H21N
6-tert-Butyl-2,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C21H27N, CAS 41958-50-3
6-tert-Butyl-2,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
CAS 41958-50-3C21H27N
Ethyl 6-tert-butyl-3-methyl-4-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate chemical structure, C23H29NO2, CAS 41958-51-4
Ethyl 6-tert-butyl-3-methyl-4-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS 41958-51-4C23H29NO2
3-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline--hydrogen bromide (1/1) chemical structure, C16H18BrN, CAS 41958-56-9
3-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline--hydrogen bromide (1/1)
CAS 41958-56-9C16H18BrN
Ethyl 3-methyl-4-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate chemical structure, C19H21NO2, CAS 41958-57-0
Ethyl 3-methyl-4-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS 41958-57-0C19H21NO2
6-Chloro-2,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1) chemical structure, C17H19Cl2N, CAS 41958-58-1
6-Chloro-2,3-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1)
CAS 41958-58-1C17H19Cl2N
Isoquinoline, 1,2,3,4-tetrahydro-6,8-dichloro-2,3-dimethyl-4-phenyl-, hydrochloride, (E)- chemical structure, C17H18Cl3N, CAS 41958-59-2
Isoquinoline, 1,2,3,4-tetrahydro-6,8-dichloro-2,3-dimethyl-4-phenyl-, hydrochloride, (E)-
CAS 41958-59-2C17H18Cl3N
2,3-Dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-6-amine chemical structure, C17H20N2, CAS 41958-61-6
2,3-Dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-6-amine
CAS 41958-61-6C17H20N2
N-(2,3-Dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-6-yl)ethanimidic acid chemical structure, C19H22N2O, CAS 41958-62-7
N-(2,3-Dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-6-yl)ethanimidic acid
CAS 41958-62-7C19H22N2O
3-(3-Methyl-4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propanenitrile chemical structure, C19H20N2, CAS 41958-63-8
3-(3-Methyl-4-phenyl-3,4-dihydroisoquinolin-2(1H)-yl)propanenitrile
CAS 41958-63-8C19H20N2
2(1H)-Isoquinolinepropionamide, 3,4-dihydro-3-methyl-4-phenyl-, (E)- chemical structure, C19H22N2O, CAS 41958-64-9
2(1H)-Isoquinolinepropionamide, 3,4-dihydro-3-methyl-4-phenyl-, (E)-
CAS 41958-64-9C19H22N2O
2,3-Dimethyl-6-nitro-4-phenyl-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1) chemical structure, C17H19ClN2O2, CAS 63937-33-7
2,3-Dimethyl-6-nitro-4-phenyl-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1)
CAS 63937-33-7C17H19ClN2O2
(S)-Nomifensine chemical structure, C16H18N2, CAS 89664-18-6
(S)-Nomifensine
CAS 89664-18-6C16H18N2
Diclofensine chemical structure, C17H17Cl2NO, CAS 67165-56-4
Diclofensine
CAS 67165-56-4C17H17Cl2NO
Cherylline chemical structure, C17H19NO3, CAS 23367-61-5
Cherylline
CAS 23367-61-5C17H19NO3
4-Phenyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C15H15N, CAS 89160-45-2
4-Phenyl-1,2,3,4-tetrahydroisoquinoline
CAS 89160-45-2C15H15N
4-(3,4-Dihydroxyphenyl)-7-hydroxy-8-methyl-1,2,3,4-tetrahydroisoquinoline chemical structure, C16H17NO3, CAS 139233-51-5
4-(3,4-Dihydroxyphenyl)-7-hydroxy-8-methyl-1,2,3,4-tetrahydroisoquinoline
CAS 139233-51-5C16H17NO3
Gastrofenzin chemical structure, C19H22Cl2N2O2, CAS 89845-17-0
Gastrofenzin
CAS 89845-17-0C19H22Cl2N2O2
Ethyl N-[4-(4-chlorophenyl)-2-methyl-3,4-dihydro-1H-isoquinolin-8-yl]carbamate chemical structure, C19H21ClN2O2, CAS 89845-16-9
Ethyl N-[4-(4-chlorophenyl)-2-methyl-3,4-dihydro-1H-isoquinolin-8-yl]carbamate
CAS 89845-16-9C19H21ClN2O2
2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine hydrochloride chemical structure, C16H19ClN2, CAS 78164-59-7
2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine hydrochloride
CAS 78164-59-7C16H19ClN2
Diclofensine hydrochloride chemical structure, C17H18Cl3NO, CAS 34041-84-4
Diclofensine hydrochloride
CAS 34041-84-4C17H18Cl3NO
4-(8-Amino-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl)phenol chemical structure, C16H18N2O, CAS 55774-26-0
4-(8-Amino-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl)phenol
CAS 55774-26-0C16H18N2O
3'-Hydroxy-4'-methoxynomifensine chemical structure, C17H20N2O2, CAS 60520-18-5
3'-Hydroxy-4'-methoxynomifensine
CAS 60520-18-5C17H20N2O2