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Murcko scaffold

1-Phenyl-4-(pyridin-2-yl)piperazine scaffold

244 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
244
With full pages
2
Scaffold SMILES

c1ccc(N2CCN(c3ccccn3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Phenyl-4-(pyridin-2-yl)piperazine page
Murcko scaffold c1ccc(N2CCN(c3ccccn3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 244 chemicals

1-(2,4-Dimethylphenyl)-4-(5-nitropyridin-2-yl)piperazine chemical structure, C17H20N4O2, CAS 400088-99-5
1-(2,4-Dimethylphenyl)-4-(5-nitropyridin-2-yl)piperazine
CAS 400088-99-5C17H20N4O2
N-[2-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}-5-(trifluoromethyl)phenyl](trifluoro)methanesulfonamide chemical structure, C18H14ClF9N4O2S, CAS 338411-86-2
N-[2-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}-5-(trifluoromethyl)phenyl](trifluoro)methanesulfonamide
CAS 338411-86-2C18H14ClF9N4O2S
1-{6-[4-(4-Fluorophenyl)piperazino]-2-methyl-3-pyridinyl}-1-ethanone chemical structure, C18H20FN3O, CAS 478260-06-9
1-{6-[4-(4-Fluorophenyl)piperazino]-2-methyl-3-pyridinyl}-1-ethanone
CAS 478260-06-9C18H20FN3O
1-(3-Nitropyridin-2-yl)-4-phenylpiperazine chemical structure, C15H16N4O2, CAS 73291-11-9
1-(3-Nitropyridin-2-yl)-4-phenylpiperazine
CAS 73291-11-9C15H16N4O2
1-(3,4-Dichlorophenyl)-4-(5-nitro-2-pyridinyl)piperazine chemical structure, C15H14Cl2N4O2, CAS 400088-96-2
1-(3,4-Dichlorophenyl)-4-(5-nitro-2-pyridinyl)piperazine
CAS 400088-96-2C15H14Cl2N4O2
Allyl 6-[4-(2,5-dimethylphenyl)piperazino]nicotinate chemical structure, C21H25N3O2, CAS 400086-77-3
Allyl 6-[4-(2,5-dimethylphenyl)piperazino]nicotinate
CAS 400086-77-3C21H25N3O2
4-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}benzenecarboxamide chemical structure, C17H16ClF3N4O, CAS 338979-27-4
4-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}benzenecarboxamide
CAS 338979-27-4C17H16ClF3N4O
1-(4-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}phenyl)-1-ethanone chemical structure, C18H17ClF3N3O, CAS 338979-19-4
1-(4-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}phenyl)-1-ethanone
CAS 338979-19-4C18H17ClF3N3O
1-(3,4-Dichlorophenyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine chemical structure, C16H14Cl2F3N3, CAS 400089-02-3
1-(3,4-Dichlorophenyl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine
CAS 400089-02-3C16H14Cl2F3N3
4-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}-N-[(dimethylamino)methylene]benzenecarboxamide chemical structure, C20H21ClF3N5O, CAS 1164512-96-2
4-{4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]piperazino}-N-[(dimethylamino)methylene]benzenecarboxamide
CAS 1164512-96-2C20H21ClF3N5O
Allyl 6-[4-(3-chlorophenyl)piperazino]nicotinate chemical structure, C19H20ClN3O2, CAS 400086-65-9
Allyl 6-[4-(3-chlorophenyl)piperazino]nicotinate
CAS 400086-65-9C19H20ClN3O2
Isopropyl 2-[4-(3-chlorophenyl)piperazino]nicotinate chemical structure, C19H22ClN3O2, CAS 400825-60-7
Isopropyl 2-[4-(3-chlorophenyl)piperazino]nicotinate
CAS 400825-60-7C19H22ClN3O2
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(4-nitrophenyl)piperazine chemical structure, C16H14ClF3N4O2, CAS 478262-11-2
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-(4-nitrophenyl)piperazine
CAS 478262-11-2C16H14ClF3N4O2
Allyl 6-[4-(2-fluorophenyl)piperazino]nicotinate chemical structure, C19H20FN3O2, CAS 400086-64-8
Allyl 6-[4-(2-fluorophenyl)piperazino]nicotinate
CAS 400086-64-8C19H20FN3O2
1-(4-Fluorophenyl)-4-(5-nitropyridin-2-yl)piperazine chemical structure, C15H15FN4O2, CAS 400088-82-6
1-(4-Fluorophenyl)-4-(5-nitropyridin-2-yl)piperazine
CAS 400088-82-6C15H15FN4O2
1-(5-Nitro-2-pyridinyl)-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C16H15F3N4O2, CAS 400088-85-9
1-(5-Nitro-2-pyridinyl)-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 400088-85-9C16H15F3N4O2
Isopropyl 2-(4-phenylpiperazino)nicotinate chemical structure, C19H23N3O2, CAS 338792-72-6
Isopropyl 2-(4-phenylpiperazino)nicotinate
CAS 338792-72-6C19H23N3O2
1-(2,5-Dimethylphenyl)-4-(3-nitropyridin-2-yl)piperazine chemical structure, C17H20N4O2, CAS 400088-95-1
1-(2,5-Dimethylphenyl)-4-(3-nitropyridin-2-yl)piperazine
CAS 400088-95-1C17H20N4O2
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[2,6-dinitro-4-(trifluoromethyl)phenyl]piperazine chemical structure, C17H12ClF6N5O4, CAS 338979-22-9
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-4-[2,6-dinitro-4-(trifluoromethyl)phenyl]piperazine
CAS 338979-22-9C17H12ClF6N5O4
Methyl 3-nitro-4-[4-(2-pyridinyl)piperazino]benzenecarboxylate chemical structure, C17H18N4O4, CAS 478246-35-4
Methyl 3-nitro-4-[4-(2-pyridinyl)piperazino]benzenecarboxylate
CAS 478246-35-4C17H18N4O4
1-(4-Methanesulfonylphenyl)-4-(pyridin-2-yl)piperazine chemical structure, C16H19N3O2S, CAS 887451-68-5
1-(4-Methanesulfonylphenyl)-4-(pyridin-2-yl)piperazine
CAS 887451-68-5C16H19N3O2S
Propan-2-yl 2-[4-(4-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate chemical structure, C19H22FN3O2, CAS 400085-30-5
Propan-2-yl 2-[4-(4-fluorophenyl)piperazin-1-yl]pyridine-3-carboxylate
CAS 400085-30-5C19H22FN3O2
1-(4-Fluorophenyl)-4-(3-nitro-2-pyridinyl)piperazine chemical structure, C15H15FN4O2, CAS 400088-90-6
1-(4-Fluorophenyl)-4-(3-nitro-2-pyridinyl)piperazine
CAS 400088-90-6C15H15FN4O2
1-(2,4-Dimethylphenyl)-4-(3-nitropyridin-2-yl)piperazine chemical structure, C17H20N4O2, CAS 400089-01-2
1-(2,4-Dimethylphenyl)-4-(3-nitropyridin-2-yl)piperazine
CAS 400089-01-2C17H20N4O2