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Murcko scaffold

Ring system with 3 rings and 15 atoms

78 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
15
Chemicals
78
With full pages
3
Scaffold SMILES

c1ccc(-c2c[nH]c3ncncc23)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2c[nH]c3ncncc23)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 78 chemicals

1-(4-Amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo(2,3-d)pyrimidin-6-yl)-2-fluoroethanone chemical structure, C18H19FN4O2, CAS 821794-92-7
1-(4-Amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo(2,3-d)pyrimidin-6-yl)-2-fluoroethanone
CAS 821794-92-7C18H19FN4O2
5-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C12H10N4, CAS 1501-13-9
5-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 1501-13-9C12H10N4
5-(4-Methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amine chemical structure, C13H12N4O, CAS 121405-37-6
5-(4-Methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amine
CAS 121405-37-6C13H12N4O
Phenol, 3-[4-amino-7-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]- chemical structure, C15H16N4O, CAS 833481-75-7
Phenol, 3-[4-amino-7-(1-methylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-
CAS 833481-75-7C15H16N4O
Hydroxy-PP-Me chemical structure, C16H18N4O, CAS 833481-77-9
Hydroxy-PP-Me
CAS 833481-77-9C16H18N4O
4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C12H8ClN3, CAS 208459-81-8
4-Chloro-5-phenyl-7H-pyrrolo[2,3-d]pyrimidine
CAS 208459-81-8C12H8ClN3
1-[4-Amino-7-(3-tert-butyldimethylsilyloxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C22H32N4OSi, CAS 821794-84-7
1-[4-Amino-7-(3-tert-butyldimethylsilyloxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine
CAS 821794-84-7C22H32N4OSi
6-Bromo-7-(3-(((1,1-dimethylethyl)dimethylsilyl)oxy)propyl)-5-(4-methylphenyl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine chemical structure, C22H31BrN4OSi, CAS 821794-85-8
6-Bromo-7-(3-(((1,1-dimethylethyl)dimethylsilyl)oxy)propyl)-5-(4-methylphenyl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine
CAS 821794-85-8C22H31BrN4OSi
5-(p-Tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C13H12N4, CAS 121405-36-5
5-(p-Tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 121405-36-5C13H12N4
1-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-chloroethanone chemical structure, C18H19ClN4O2, CAS 821794-90-5
1-(4-Amino-7-(3-hydroxypropyl)-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-chloroethanone
CAS 821794-90-5C18H19ClN4O2
4-Chloro-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C13H10ClN3, CAS 208459-77-2
4-Chloro-5-(p-tolyl)-7H-pyrrolo[2,3-d]pyrimidine
CAS 208459-77-2C13H10ClN3
4-Chloro-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C13H10ClN3O, CAS 208459-78-3
4-Chloro-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine
CAS 208459-78-3C13H10ClN3O
5-(4-Fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C12H9FN4, CAS 1230845-28-9
5-(4-Fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 1230845-28-9C12H9FN4
5-(3-Methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amine chemical structure, C13H12N4O, CAS 194787-34-3
5-(3-Methoxy-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amine
CAS 194787-34-3C13H12N4O
5-(3-(Trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C13H9F3N4, CAS 1230844-92-4
5-(3-(Trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 1230844-92-4C13H9F3N4
5-(m-Tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C13H12N4, CAS 1230847-80-9
5-(m-Tolyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 1230847-80-9C13H12N4
5-(4-Chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C12H9ClN4, CAS 1151652-95-7
5-(4-Chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 1151652-95-7C12H9ClN4
5-(3-Chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C12H9ClN4, CAS 1230845-40-5
5-(3-Chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 1230845-40-5C12H9ClN4
5-(3-Fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C12H9FN4, CAS 1230845-27-8
5-(3-Fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 1230845-27-8C12H9FN4
5-(4-(Trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C13H9F3N4, CAS 1230845-05-2
5-(4-(Trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 1230845-05-2C13H9F3N4
4-Amino-7-isopropyl-5-(4-methoxyphenyl) pyrrolo[2,3-d]pyrimidine chemical structure, C16H18N4O, CAS 213744-87-7
4-Amino-7-isopropyl-5-(4-methoxyphenyl) pyrrolo[2,3-d]pyrimidine
CAS 213744-87-7C16H18N4O
4-Chloro-5-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidine chemical structure, C13H7ClF3N3, CAS 1072027-17-8
4-Chloro-5-(4-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidine
CAS 1072027-17-8C13H7ClF3N3
7-tert-Butyl-5-(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine chemical structure, C16H17ClN4, CAS 309739-67-1
7-tert-Butyl-5-(4-chlorophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
CAS 309739-67-1C16H17ClN4
3-(4-Amino-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-ol chemical structure, C16H18N4O, CAS 821794-94-9
3-(4-Amino-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propan-1-ol
CAS 821794-94-9C16H18N4O