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Murcko scaffold

1-Benzoyl-4-phenylpiperazine scaffold

844 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
844
With full pages
7
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzoyl-4-phenylpiperazine page
Murcko scaffold O=C(c1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 385 to 432 of 844 chemicals

[4-(3-Chlorophenyl)piperazin-1-yl]-(4,5-dimethoxy-2-nitrophenyl)methanone chemical structure, C19H20ClN3O5, CAS 349399-63-9
[4-(3-Chlorophenyl)piperazin-1-yl]-(4,5-dimethoxy-2-nitrophenyl)methanone
CAS 349399-63-9C19H20ClN3O5
4-(tert-Butyl)phenyl 4-(3-(trifluoromethyl)phenyl)piperazinyl ketone chemical structure, C22H25F3N2O, CAS 432532-43-9
4-(tert-Butyl)phenyl 4-(3-(trifluoromethyl)phenyl)piperazinyl ketone
CAS 432532-43-9C22H25F3N2O
N-[2-(4-Benzoylpiperazin-1-yl)phenyl]-2,2,2-trichloroacetamide chemical structure, C19H18Cl3N3O2, CAS 579440-84-9
N-[2-(4-Benzoylpiperazin-1-yl)phenyl]-2,2,2-trichloroacetamide
CAS 579440-84-9C19H18Cl3N3O2
{3-Chloro-4-[4-(4-propoxybenzoyl)piperazin-1-yl]phenyl}amine chemical structure, C20H24ClN3O2, CAS 640759-20-2
{3-Chloro-4-[4-(4-propoxybenzoyl)piperazin-1-yl]phenyl}amine
CAS 640759-20-2C20H24ClN3O2
4-(4-Benzoylpiperazin-1-yl)benzoic acid chemical structure, C18H18N2O3, CAS 94038-27-4
4-(4-Benzoylpiperazin-1-yl)benzoic acid
CAS 94038-27-4C18H18N2O3
(5-Chloro-2-methoxyphenyl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H21ClN2O3, CAS 782466-66-4
(5-Chloro-2-methoxyphenyl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 782466-66-4C19H21ClN2O3
1-(5-Chloro-2-methylphenyl)-4-(3,4,5-trimethoxybenzoyl)piperazine chemical structure, C21H25ClN2O4, CAS 745024-96-8
1-(5-Chloro-2-methylphenyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
CAS 745024-96-8C21H25ClN2O4
4-(2-Methylphenyl)piperazinyl 3-nitrophenyl ketone chemical structure, C18H19N3O3, CAS 680868-72-8
4-(2-Methylphenyl)piperazinyl 3-nitrophenyl ketone
CAS 680868-72-8C18H19N3O3
3,5-Dinitrophenyl 4-(2-methylphenyl)piperazinyl ketone chemical structure, C18H18N4O5, CAS 289061-09-2
3,5-Dinitrophenyl 4-(2-methylphenyl)piperazinyl ketone
CAS 289061-09-2C18H18N4O5
1-(4-Chlorobenzoyl)-4-(2-methylphenyl)piperazine chemical structure, C18H19ClN2O, CAS 868153-33-7
1-(4-Chlorobenzoyl)-4-(2-methylphenyl)piperazine
CAS 868153-33-7C18H19ClN2O
1-(3,4-Dimethoxybenzoyl)-4-(2-methylphenyl)piperazine chemical structure, C20H24N2O3, CAS 825607-13-4
1-(3,4-Dimethoxybenzoyl)-4-(2-methylphenyl)piperazine
CAS 825607-13-4C20H24N2O3
4-(2,3-Dichlorophenyl)piperazinyl 3-nitrophenyl ketone chemical structure, C17H15Cl2N3O3, CAS 868153-34-8
4-(2,3-Dichlorophenyl)piperazinyl 3-nitrophenyl ketone
CAS 868153-34-8C17H15Cl2N3O3
1-Phenyl-4-{3-[(2,2,3,3-tetrafluoropropoxy)methyl]benzoyl}piperazine chemical structure, C21H22F4N2O2, CAS 445258-70-8
1-Phenyl-4-{3-[(2,2,3,3-tetrafluoropropoxy)methyl]benzoyl}piperazine
CAS 445258-70-8C21H22F4N2O2
[4-(4-Chlorophenyl)piperazin-1-yl]-(2-methoxyphenyl)methanone chemical structure, C18H19ClN2O2, CAS 544661-19-0
[4-(4-Chlorophenyl)piperazin-1-yl]-(2-methoxyphenyl)methanone
CAS 544661-19-0C18H19ClN2O2
[4-(3-Chlorophenyl)piperazin-1-yl]-(2,4-dinitrophenyl)methanone chemical structure, C17H15ClN4O5, CAS 416891-56-0
[4-(3-Chlorophenyl)piperazin-1-yl]-(2,4-dinitrophenyl)methanone
CAS 416891-56-0C17H15ClN4O5
(2,4-Dimethoxyphenyl)[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C20H24N2O4, CAS 694501-08-1
(2,4-Dimethoxyphenyl)[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 694501-08-1C20H24N2O4
N-[4-[4-(4-Methylbenzoyl)piperazin-1-yl]phenyl]pentanamide chemical structure, C23H29N3O2, CAS 642417-11-6
N-[4-[4-(4-Methylbenzoyl)piperazin-1-yl]phenyl]pentanamide
CAS 642417-11-6C23H29N3O2
N-[4-[4-(2-Fluorophenyl)piperazine-1-carbonyl]phenyl]butanamide chemical structure, C21H24FN3O2, CAS 702647-55-0
N-[4-[4-(2-Fluorophenyl)piperazine-1-carbonyl]phenyl]butanamide
CAS 702647-55-0C21H24FN3O2
N-[4-[4-(3-Chlorophenyl)piperazine-1-carbonyl]phenyl]butanamide chemical structure, C21H24ClN3O2, CAS 702647-82-3
N-[4-[4-(3-Chlorophenyl)piperazine-1-carbonyl]phenyl]butanamide
CAS 702647-82-3C21H24ClN3O2
N-[4-[4-(2-Fluorophenyl)piperazine-1-carbonyl]phenyl]pentanamide chemical structure, C22H26FN3O2, CAS 663185-64-6
N-[4-[4-(2-Fluorophenyl)piperazine-1-carbonyl]phenyl]pentanamide
CAS 663185-64-6C22H26FN3O2
[4-(3-Chlorophenyl)piperazin-1-yl]-(3,5-dichloro-4-methoxyphenyl)methanone chemical structure, C18H17Cl3N2O2, CAS 824422-69-7
[4-(3-Chlorophenyl)piperazin-1-yl]-(3,5-dichloro-4-methoxyphenyl)methanone
CAS 824422-69-7C18H17Cl3N2O2
N-[4-[4-(3-Chlorophenyl)piperazine-1-carbonyl]phenyl]pentanamide chemical structure, C22H26ClN3O2, CAS 663183-67-3
N-[4-[4-(3-Chlorophenyl)piperazine-1-carbonyl]phenyl]pentanamide
CAS 663183-67-3C22H26ClN3O2
(2-Ethylsulfanylphenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C20H24N2O2S, CAS 663187-52-8
(2-Ethylsulfanylphenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 663187-52-8C20H24N2O2S
N-[4-[4-(2,3-Dimethylphenyl)piperazine-1-carbonyl]phenyl]pentanamide chemical structure, C24H31N3O2, CAS 663185-42-0
N-[4-[4-(2,3-Dimethylphenyl)piperazine-1-carbonyl]phenyl]pentanamide
CAS 663185-42-0C24H31N3O2