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Murcko scaffold

1-Benzoyl-4-phenylpiperazine scaffold

844 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
844
With full pages
177
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzoyl-4-phenylpiperazine page
Murcko scaffold O=C(c1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 289 to 336 of 844 chemicals

N-[4-[4-[3-(Trifluoromethyl)phenyl]piperazine-1-carbonyl]phenyl]butanamide chemical structure, C22H24F3N3O2, CAS 702648-51-9
N-[4-[4-[3-(Trifluoromethyl)phenyl]piperazine-1-carbonyl]phenyl]butanamide
CAS 702648-51-9C22H24F3N3O2
(2,4-Dichlorophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H20Cl2N2O2, CAS 312704-85-1
(2,4-Dichlorophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 312704-85-1C19H20Cl2N2O2
(3-Bromophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H21BrN2O2, CAS 353780-62-8
(3-Bromophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 353780-62-8C19H21BrN2O2
(2-Bromophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H21BrN2O2, CAS 314023-81-9
(2-Bromophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 314023-81-9C19H21BrN2O2
(2,4-Dichlorophenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C19H20Cl2N2O, CAS 314023-74-0
(2,4-Dichlorophenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone
CAS 314023-74-0C19H20Cl2N2O
(4-Chloro-2-nitrophenyl)(4-(2-methoxyphenyl)piperazin-1-yl)methanone chemical structure, C18H18ClN3O4, CAS 330215-54-8
(4-Chloro-2-nitrophenyl)(4-(2-methoxyphenyl)piperazin-1-yl)methanone
CAS 330215-54-8C18H18ClN3O4
4-(2-Ethoxyphenyl)piperazinyl 4-nitrophenyl ketone chemical structure, C19H21N3O4, CAS 5702-37-4
4-(2-Ethoxyphenyl)piperazinyl 4-nitrophenyl ketone
CAS 5702-37-4C19H21N3O4
[4-(4-Chlorophenyl)piperazin-1-yl]-(2,6-dichlorophenyl)methanone chemical structure, C17H15Cl3N2O, CAS 353473-21-9
[4-(4-Chlorophenyl)piperazin-1-yl]-(2,6-dichlorophenyl)methanone
CAS 353473-21-9C17H15Cl3N2O
(3,5-Dimethoxyphenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C21H26N2O3, CAS 329050-02-4
(3,5-Dimethoxyphenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone
CAS 329050-02-4C21H26N2O3
(2,6-Dimethoxyphenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C21H26N2O4, CAS 352679-27-7
(2,6-Dimethoxyphenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 352679-27-7C21H26N2O4
(2-Chloro-4-nitrophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone chemical structure, C19H20ClN3O4, CAS 354994-78-8
(2-Chloro-4-nitrophenyl)-[4-(2-ethoxyphenyl)piperazin-1-yl]methanone
CAS 354994-78-8C19H20ClN3O4
(4-Chloro-2-nitrophenyl)-[4-(4-chlorophenyl)piperazin-1-yl]methanone chemical structure, C17H15Cl2N3O3, CAS 550306-34-8
(4-Chloro-2-nitrophenyl)-[4-(4-chlorophenyl)piperazin-1-yl]methanone
CAS 550306-34-8C17H15Cl2N3O3
1-{5-Chloro-2-nitrobenzoyl}-4-(4-fluorophenyl)piperazine chemical structure, C17H15ClFN3O3, CAS 340014-67-7
1-{5-Chloro-2-nitrobenzoyl}-4-(4-fluorophenyl)piperazine
CAS 340014-67-7C17H15ClFN3O3
1-(4-Bromobenzoyl)-4-(2,3-dimethylphenyl)piperazine chemical structure, C19H21BrN2O, CAS 349613-47-4
1-(4-Bromobenzoyl)-4-(2,3-dimethylphenyl)piperazine
CAS 349613-47-4C19H21BrN2O
(5-Chloro-2-nitrophenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C18H18ClN3O4, CAS 352693-04-0
(5-Chloro-2-nitrophenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 352693-04-0C18H18ClN3O4
(5-Chloro-2-nitrophenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone chemical structure, C19H20ClN3O3, CAS 540802-22-0
(5-Chloro-2-nitrophenyl)-[4-(2,3-dimethylphenyl)piperazin-1-yl]methanone
CAS 540802-22-0C19H20ClN3O3
(2,6-Difluorophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C18H15F5N2O, CAS 444907-13-5
(2,6-Difluorophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 444907-13-5C18H15F5N2O
[4-(3-Chlorophenyl)piperazin-1-yl]-(2-ethylsulfanylphenyl)methanone chemical structure, C19H21ClN2OS, CAS 663186-18-3
[4-(3-Chlorophenyl)piperazin-1-yl]-(2-ethylsulfanylphenyl)methanone
CAS 663186-18-3C19H21ClN2OS
[4-(4-Methoxyphenyl)piperazin-1-yl]-(2-methyl-3-nitrophenyl)methanone chemical structure, C19H21N3O4, CAS 432021-00-6
[4-(4-Methoxyphenyl)piperazin-1-yl]-(2-methyl-3-nitrophenyl)methanone
CAS 432021-00-6C19H21N3O4
1-[4-[4-(2-Chloro-4,5-difluorobenzoyl)piperazin-1-yl]-3-fluorophenyl]ethanone chemical structure, C19H16ClF3N2O2, CAS 330636-58-3
1-[4-[4-(2-Chloro-4,5-difluorobenzoyl)piperazin-1-yl]-3-fluorophenyl]ethanone
CAS 330636-58-3C19H16ClF3N2O2
1-[4-(4-Benzoylpiperazin-1-yl)phenyl]ethanone chemical structure, C19H20N2O2, CAS 717857-64-2
1-[4-(4-Benzoylpiperazin-1-yl)phenyl]ethanone
CAS 717857-64-2C19H20N2O2
(2-Fluorophenyl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C18H19FN2O2, CAS 774589-64-9
(2-Fluorophenyl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 774589-64-9C18H19FN2O2
(2-Iodophenyl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C18H19IN2O2, CAS 830349-41-2
(2-Iodophenyl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 830349-41-2C18H19IN2O2
[4-(3,4-Dichlorophenyl)piperazin-1-yl]-[4-(3-hydroxy-3-methylbut-1-ynyl)phenyl]methanone chemical structure, C22H22Cl2N2O2, CAS 361465-65-8
[4-(3,4-Dichlorophenyl)piperazin-1-yl]-[4-(3-hydroxy-3-methylbut-1-ynyl)phenyl]methanone
CAS 361465-65-8C22H22Cl2N2O2