Murcko scaffold
1-Benzyl-4-phenylpiperazine scaffold
489 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 19
- Chemicals
- 489
- With full pages
- 40
Scaffold SMILES
c1ccc(CN2CCN(c3ccccc3)CC2)cc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 489 chemicals
1-(3-Methoxy-4-hydroxybenzyl)-4-phenylpiperazine
CAS 63867-54-9C18H22N2O2
1-(3,4-Dimethoxy-benzyl)-4-(2-chlorophenyl)piperazine
CAS 63978-29-0C19H23ClN2O2
1-(3,4-Dimethoxybenzyl)-4-(4-chlorophenyl)piperazine
CAS 63978-30-3C19H23ClN2O2
Piperazine, 1-(3,4-dimethoxybenzyl)-4-(4-methoxyphenyl)-
CAS 63978-35-8C20H26N2O3
Piperazine, 1-(2,5-dimethoxybenzyl)-4-phenyl-
CAS 63978-38-1C19H24N2O2
Piperazine, 1-(3,4-dimethoxybenzyl)-4-phenyl-
CAS 63978-39-2C19H24N2O2
2-(4-Methylphenyl)-2-(4-phenylpiperazin-1-yl)ethan-1-ol
CAS 7550-24-5C19H24N2O
1-Benzyl-4-(4-chlorophenyl)piperazine
CAS 6334-05-0C17H19ClN2
1-(4-Nitrobenzyl)-4-phenylpiperazine
CAS 40224-22-4C17H19N3O2
![N-[4-Hydroxy-3-[(4-phenylpiperazin-1-yl)methyl]phenyl]acetamide chemical structure, C19H23N3O2, CAS 77726-10-4](/s/QUKJEHJRISSJIB-UHFFFAOYSA-N.svg)
N-[4-Hydroxy-3-[(4-phenylpiperazin-1-yl)methyl]phenyl]acetamide
CAS 77726-10-4C19H23N3O2
1-(4-Chlorobenzyl)-4-phenylpiperazine
CAS 210831-42-8C17H19ClN2
1-Benzyl-4-phenylpiperazine
CAS 3074-46-2C17H20N2
1-Benzyl-4-(2-nitrophenyl)piperazine
CAS 199105-16-3C17H19N3O2
![N-[4-(4-Benzylpiperazin-1-yl)phenyl]propanamide chemical structure, C20H25N3O, CAS 640239-46-9](/s/KANFRUSNGPHTDQ-UHFFFAOYSA-N.svg)
N-[4-(4-Benzylpiperazin-1-yl)phenyl]propanamide
CAS 640239-46-9C20H25N3O
![N-{4-[4-(2-Fluoro-benzyl)-piperazin-1-yl]-phenyl}-acetamide chemical structure, C19H22FN3O, CAS 797781-63-6](/s/JKEVCKARBFJSSC-UHFFFAOYSA-N.svg)
N-{4-[4-(2-Fluoro-benzyl)-piperazin-1-yl]-phenyl}-acetamide
CAS 797781-63-6C19H22FN3O
![Ethyl 2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-phenylacetate chemical structure, C21H26N2O3, CAS 690991-57-2](/s/WOHBAKBGVKUKMH-UHFFFAOYSA-N.svg)
Ethyl 2-[4-(4-methoxyphenyl)piperazin-1-yl]-2-phenylacetate
CAS 690991-57-2C21H26N2O3
3-((4-Phenylpiperazin-1-yl)methyl)benzoic acid
CAS 294876-97-4C18H20N2O2
![4-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}benzoic acid chemical structure, C19H22N2O3, CAS 358387-25-4](/s/KPXOKVXKHGAASR-UHFFFAOYSA-N.svg)
4-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}benzoic acid
CAS 358387-25-4C19H22N2O3
4-(4-Benzylpiperazin-1-yl)aniline
CAS 16154-69-1C17H21N3
1-(2,4-Dichlorobenzyl)-4-(2-fluorophenyl)piperazine
CAS 331976-15-9C17H17Cl2FN2
![1-[4-(4-Benzylpiperazin-1-yl)phenyl]ethanone chemical structure, C19H22N2O, CAS 163733-55-9](/s/AUTPNGXKYQJLBF-UHFFFAOYSA-N.svg)
1-[4-(4-Benzylpiperazin-1-yl)phenyl]ethanone
CAS 163733-55-9C19H22N2O
![1-(2,3-Dimethylphenyl)-4-[(3-nitrophenyl)methyl]piperazine chemical structure, C19H23N3O2, CAS 414881-08-6](/s/AEHLQHIGYPNBIT-UHFFFAOYSA-N.svg)
1-(2,3-Dimethylphenyl)-4-[(3-nitrophenyl)methyl]piperazine
CAS 414881-08-6C19H23N3O2
![4-[(4-Phenylpiperazin-1-yl)methyl]phenol chemical structure, C17H20N2O, CAS 82965-59-1](/s/KFFAXWKHIJAKRD-UHFFFAOYSA-N.svg)
4-[(4-Phenylpiperazin-1-yl)methyl]phenol
CAS 82965-59-1C17H20N2O
![1-[(2-Methylphenyl)methyl]-4-phenylpiperazine chemical structure, C18H22N2, CAS 203637-74-5](/s/SBZDGERKAMLRED-UHFFFAOYSA-N.svg)
1-[(2-Methylphenyl)methyl]-4-phenylpiperazine
CAS 203637-74-5C18H22N2
- 1-(2,4-Dimethylbenzyl)-4-(4-fluorophenyl)piperazine52899-80-6C19H23FN2
- 1-(4-Chlorophenyl)-4-(4-methoxy-2,5-dimethylbenzyl)piperazine5302-05-6C20H25ClN2O
- 1-((4-Bromophenyl)methyl)-4-phenylpiperazine368879-18-9C17H19BrN2
- 1-(2,4-Dichlorobenzyl)-4-phenylpiperazine21057-50-1C17H18Cl2N2
- 1-(4-Fluorobenzyl)-4-phenylpiperazine414884-36-9C17H19FN2
- 1-(4-Chlorophenyl)-4-(4-ethoxybenzyl)piperazine321673-44-3C19H23ClN2O
- 1-(3-Chlorophenyl)-4-[(4-methoxy-2,5-dimethylphenyl)methyl]piperazine5266-53-5C20H25ClN2O
- Piperazine, 1-(4-fluorophenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-12-0C20H26ClFN2O3
- Piperazine, 1-(3-methoxyphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-14-2C21H29ClN2O4
- Piperazine, 1-(2-ethylphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochloride80305-15-3C22H32Cl2N2O3
- Piperazine, 1-(2-ethoxyphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochloride80305-16-4C22H32Cl2N2O4
- Piperazine, 1-(2-nitrophenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-17-5C20H26ClN3O5
- Phenol, 4-(4-((3,4,5-trimethoxyphenyl)methyl)-1-piperazinyl)-, monohydrochloride80305-18-6C20H27ClN2O4
- Piperazine, 1-(2-chlorophenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochloride80305-19-7C20H27Cl3N2O3
- Piperazine, 1-(2-methoxyphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochloride80305-20-0C21H30Cl2N2O4
- Piperazine, 1-(4-methoxyphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, dihydrochloride80305-21-1C21H30Cl2N2O4
- Piperazine, 1-(2-fluorophenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-23-3C20H26ClFN2O3
- Piperazine, 1-(3-methylphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-24-4C21H29ClN2O3
- Piperazine, 1-(4-methylphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-25-5C21H29ClN2O3
- Piperazine, 1-(3,4-dimethylphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-27-7C22H31ClN2O3
- Piperazine, 1-(4-chloro-3-(trifluoromethyl)phenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-30-2C21H25Cl2F3N2O3
- Piperazine, 1-(3,4,5-trimethoxyphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-32-4C23H33ClN2O6
- Piperazine, 1-(3,5-bis(trifluoromethyl)phenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-33-5C22H25ClF6N2O3
- Piperazine, 1-(2,6-dimethylphenyl)-4-((3,4,5-trimethoxyphenyl)methyl)-, monohydrochloride80305-34-6C22H31ClN2O3
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(c1ccccc1)N1CCN(c2ccccc2)CC1177 chemicals
O=S(=O)(c1ccccc1)N1CCN(c2ccccc2)CC1130 chemicals
O=c1ccoc(CN2CCN(c3ccccc3)CC2)c130 chemicals
O=C(c1ccccc1)N1CCN(c2ccccn2)CC129 chemicals
O=S(=O)(c1ccccc1)N1CCN(c2ccccn2)CC124 chemicals
O=S(=O)(c1ccccc1)N1CCN(c2ncccn2)CC115 chemicals![Scaffold O=c1[nH]cc(S(=O)(=O)N2CCN(c3ccccc3)CC2)c(=O)[nH]1](/scaffold/NDLNPZDGZZJEQK-UHFFFAOYSA-N/structure.svg)
O=c1[nH]cc(S(=O)(=O)N2CCN(c3ccccc3)CC2)c(=O)[nH]114 chemicals
O=C(N1CCOCC1)N1CCN(c2ccccc2)CC113 chemicals
S=C(c1ccccc1)N1CCN(c2ccccc2)CC113 chemicals
c1ccc(CN2CCN(c3ccccn3)CC2)cc112 chemicals
O=C(c1ccccc1)N1CCN(c2ncccn2)CC112 chemicals
c1ccc(CN2CCC(c3ccccc3)CC2)cc110 chemicals