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Murcko scaffold

1-Benzoyl-4-phenylpiperazine scaffold

844 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
844
With full pages
7
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-Benzoyl-4-phenylpiperazine page
Murcko scaffold O=C(c1ccccc1)N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 337 to 384 of 844 chemicals

N-[3-[4-(3-Chlorophenyl)piperazine-1-carbonyl]phenyl]-2-methylpropanamide chemical structure, C21H24ClN3O2, CAS 599189-30-7
N-[3-[4-(3-Chlorophenyl)piperazine-1-carbonyl]phenyl]-2-methylpropanamide
CAS 599189-30-7C21H24ClN3O2
4-({4-[3-(Trifluoromethyl)phenyl]piperazinyl}carbonyl)phenyl acetate chemical structure, C20H19F3N2O3, CAS 724734-49-0
4-({4-[3-(Trifluoromethyl)phenyl]piperazinyl}carbonyl)phenyl acetate
CAS 724734-49-0C20H19F3N2O3
(4-Methoxy-3-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C19H18F3N3O4, CAS 432503-46-3
(4-Methoxy-3-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 432503-46-3C19H18F3N3O4
(3-Bromophenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C17H16BrFN2O, CAS 432508-00-4
(3-Bromophenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 432508-00-4C17H16BrFN2O
(4,5-Dimethoxy-2-nitrophenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C19H20FN3O5, CAS 432520-54-2
(4,5-Dimethoxy-2-nitrophenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 432520-54-2C19H20FN3O5
[4-(2-Fluorophenyl)piperazin-1-yl]-(3-iodophenyl)methanone chemical structure, C17H16FIN2O, CAS 667408-60-8
[4-(2-Fluorophenyl)piperazin-1-yl]-(3-iodophenyl)methanone
CAS 667408-60-8C17H16FIN2O
(4-Chloro-3-nitrophenyl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone chemical structure, C18H15ClF3N3O3, CAS 432526-03-9
(4-Chloro-3-nitrophenyl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone
CAS 432526-03-9C18H15ClF3N3O3
(4-Chloro-2-nitrophenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C17H15ClFN3O3, CAS 433235-19-9
(4-Chloro-2-nitrophenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 433235-19-9C17H15ClFN3O3
4-(tert-Butyl)phenyl 4-(5-chloro-2-methylphenyl)piperazinyl ketone chemical structure, C22H27ClN2O, CAS 693800-01-0
4-(tert-Butyl)phenyl 4-(5-chloro-2-methylphenyl)piperazinyl ketone
CAS 693800-01-0C22H27ClN2O
(3,5-Dichloro-4-ethoxyphenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C20H22Cl2N2O3, CAS 692265-64-8
(3,5-Dichloro-4-ethoxyphenyl)-[4-(2-methoxyphenyl)piperazin-1-yl]methanone
CAS 692265-64-8C20H22Cl2N2O3
1-(4-tert-Butylbenzoyl)-4-(4-methoxyphenyl)piperazine chemical structure, C22H28N2O2, CAS 431937-66-5
1-(4-tert-Butylbenzoyl)-4-(4-methoxyphenyl)piperazine
CAS 431937-66-5C22H28N2O2
(2,4-Dichlorophenyl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone chemical structure, C18H18Cl2N2O2, CAS 290363-50-7
(2,4-Dichlorophenyl)-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
CAS 290363-50-7C18H18Cl2N2O2
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl](4-methyl-3-nitrophenyl)methanone chemical structure, C19H20ClN3O3, CAS 693820-87-0
[4-(5-Chloro-2-methylphenyl)piperazin-1-yl](4-methyl-3-nitrophenyl)methanone
CAS 693820-87-0C19H20ClN3O3
(2-Chloro-4-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C18H15ClF3N3O3, CAS 432497-89-7
(2-Chloro-4-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 432497-89-7C18H15ClF3N3O3
1-(3-Fluorobenzoyl)-4-[3-(trifluoromethyl)phenyl]piperazine chemical structure, C18H16F4N2O, CAS 546119-82-8
1-(3-Fluorobenzoyl)-4-[3-(trifluoromethyl)phenyl]piperazine
CAS 546119-82-8C18H16F4N2O
[4-(2-Fluorophenyl)piperazin-1-yl]-(4-methoxy-3-nitrophenyl)methanone chemical structure, C18H18FN3O4, CAS 432500-05-5
[4-(2-Fluorophenyl)piperazin-1-yl]-(4-methoxy-3-nitrophenyl)methanone
CAS 432500-05-5C18H18FN3O4
(4-Fluorophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C18H16F4N2O, CAS 288312-16-3
(4-Fluorophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 288312-16-3C18H16F4N2O
(4,5-Dimethoxy-2-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C20H20F3N3O5, CAS 432533-79-4
(4,5-Dimethoxy-2-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 432533-79-4C20H20F3N3O5
(3-Methyl-4-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C19H18F3N3O3, CAS 432534-73-1
(3-Methyl-4-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 432534-73-1C19H18F3N3O3
(4-Chloro-2-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone chemical structure, C18H15ClF3N3O3, CAS 432540-65-3
(4-Chloro-2-nitrophenyl)-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methanone
CAS 432540-65-3C18H15ClF3N3O3
[4-(2-Fluorophenyl)piperazin-1-yl]-(2-iodophenyl)methanone chemical structure, C17H16FIN2O, CAS 432541-30-5
[4-(2-Fluorophenyl)piperazin-1-yl]-(2-iodophenyl)methanone
CAS 432541-30-5C17H16FIN2O
4-Bromophenyl 4-[3-(trifluoromethyl)phenyl]piperazinyl ketone chemical structure, C18H16BrF3N2O, CAS 433234-11-8
4-Bromophenyl 4-[3-(trifluoromethyl)phenyl]piperazinyl ketone
CAS 433234-11-8C18H16BrF3N2O
(2,4-Dichlorophenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone chemical structure, C17H15Cl2FN2O, CAS 432017-52-2
(2,4-Dichlorophenyl)-[4-(2-fluorophenyl)piperazin-1-yl]methanone
CAS 432017-52-2C17H15Cl2FN2O
(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone chemical structure, C17H15ClFN3O3, CAS 432020-20-7
(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone
CAS 432020-20-7C17H15ClFN3O3