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Murcko scaffold

Phenyl 4-(2-pyridyl)piperazinyl ketone scaffold

97 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
97
With full pages
29
Scaffold SMILES

O=C(c1ccccc1)N1CCN(c2ccccn2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Phenyl 4-(2-pyridyl)piperazinyl ketone page
Murcko scaffold O=C(c1ccccc1)N1CCN(c2ccccn2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 97 chemicals

Ketone, 4-(2-pyridyl)piperazinyl 3,4,5-trimethoxyphenyl chemical structure, C19H23N3O4, CAS 17766-77-7
Ketone, 4-(2-pyridyl)piperazinyl 3,4,5-trimethoxyphenyl
CAS 17766-77-7C19H23N3O4
(2-Bromophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C16H16BrN3O, CAS 310456-58-7
(2-Bromophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 310456-58-7C16H16BrN3O
(4-Bromophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C16H16BrN3O, CAS 296882-88-7
(4-Bromophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 296882-88-7C16H16BrN3O
1-(4-Methylbenzoyl)-4-(2-pyridinyl)piperazine chemical structure, C17H19N3O, CAS 325779-61-1
1-(4-Methylbenzoyl)-4-(2-pyridinyl)piperazine
CAS 325779-61-1C17H19N3O
(4-tert-Butylphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C20H25N3O, CAS 429630-04-6
(4-tert-Butylphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 429630-04-6C20H25N3O
1-(3,5-Dimethoxybenzoyl)-4-(2-pyridinyl)piperazine chemical structure, C18H21N3O3, CAS 369400-61-3
1-(3,5-Dimethoxybenzoyl)-4-(2-pyridinyl)piperazine
CAS 369400-61-3C18H21N3O3
(2-Fluoro-phenyl)-(4-pyridin-2-yl-piperazin-1-yl)-methanone chemical structure, C16H16FN3O, CAS 326613-25-6
(2-Fluoro-phenyl)-(4-pyridin-2-yl-piperazin-1-yl)-methanone
CAS 326613-25-6C16H16FN3O
4-Fluorophenyl 4-(2-pyridyl)piperazinyl ketone chemical structure, C16H16FN3O, CAS 332168-99-7
4-Fluorophenyl 4-(2-pyridyl)piperazinyl ketone
CAS 332168-99-7C16H16FN3O
(3-Methylphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C17H19N3O, CAS 352343-50-1
(3-Methylphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 352343-50-1C17H19N3O
(2-Chlorophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C16H16ClN3O, CAS 332391-27-2
(2-Chlorophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 332391-27-2C16H16ClN3O
(4-Methoxyphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C17H19N3O2, CAS 331989-73-2
(4-Methoxyphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 331989-73-2C17H19N3O2
(3-Methyl-4-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C17H18N4O3, CAS 431934-76-8
(3-Methyl-4-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 431934-76-8C17H18N4O3
(2,4-Dimethoxyphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C18H21N3O3, CAS 433329-18-1
(2,4-Dimethoxyphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 433329-18-1C18H21N3O3
(2-Chloro-4-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C16H15ClN4O3, CAS 381197-59-7
(2-Chloro-4-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 381197-59-7C16H15ClN4O3
(3-Chlorophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C16H16ClN3O, CAS 351892-68-7
(3-Chlorophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 351892-68-7C16H16ClN3O
(4-Chlorophenyl)-[4-(2-pyridinyl)-1-piperazinyl]methanone chemical structure, C16H16ClN3O, CAS 325779-60-0
(4-Chlorophenyl)-[4-(2-pyridinyl)-1-piperazinyl]methanone
CAS 325779-60-0C16H16ClN3O
1-(3-Bromobenzoyl)-4-(2-pyridinyl)piperazine chemical structure, C16H16BrN3O, CAS 425421-21-2
1-(3-Bromobenzoyl)-4-(2-pyridinyl)piperazine
CAS 425421-21-2C16H16BrN3O
(2-Methyl-3-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C17H18N4O3, CAS 351338-86-8
(2-Methyl-3-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 351338-86-8C17H18N4O3
(4-Methyl-3-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C17H18N4O3, CAS 335282-53-6
(4-Methyl-3-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 335282-53-6C17H18N4O3
(2,4-Dichlorophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C16H15Cl2N3O, CAS 335282-36-5
(2,4-Dichlorophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 335282-36-5C16H15Cl2N3O
(2-Chloro-5-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C16H15ClN4O3, CAS 383903-94-4
(2-Chloro-5-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 383903-94-4C16H15ClN4O3
(4-Chloro-3-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C16H15ClN4O3, CAS 426213-85-6
(4-Chloro-3-nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 426213-85-6C16H15ClN4O3
(4-Nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C16H16N4O3, CAS 335282-39-8
(4-Nitrophenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 335282-39-8C16H16N4O3
(3,4-Dimethylphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone chemical structure, C18H21N3O, CAS 690985-14-9
(3,4-Dimethylphenyl)-(4-pyridin-2-ylpiperazin-1-yl)methanone
CAS 690985-14-9C18H21N3O