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Murcko scaffold

Ring system with 3 rings and 19 atoms

53 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
53
With full pages
9
Scaffold SMILES

C1=CN(Cc2ccccc2)C=CC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C1=CN(Cc2ccccc2)C=CC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 53 chemicals

Dimethyl 4-(3-chlorophenyl)-1-(1-phenylethyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C23H22ClNO4, CAS 347326-82-3
Dimethyl 4-(3-chlorophenyl)-1-(1-phenylethyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 347326-82-3C23H22ClNO4
Dimethyl 4-(4-chlorophenyl)-1-(1-phenylethyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C23H22ClNO4, CAS 347329-96-8
Dimethyl 4-(4-chlorophenyl)-1-(1-phenylethyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 347329-96-8C23H22ClNO4
Diethyl 1-benzyl-4-{4-nitrophenyl}-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate chemical structure, C26H28N2O6, CAS 30131-53-4
Diethyl 1-benzyl-4-{4-nitrophenyl}-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
CAS 30131-53-4C26H28N2O6
Dimethyl 4-(2,5-dimethoxyphenyl)-1-(4-fluorobenzyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C24H24FNO6, CAS 347313-20-6
Dimethyl 4-(2,5-dimethoxyphenyl)-1-(4-fluorobenzyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 347313-20-6C24H24FNO6
Dimethyl 1-(3,4-dimethoxybenzyl)-4-(3,4-dimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C26H29NO8, CAS 347352-16-3
Dimethyl 1-(3,4-dimethoxybenzyl)-4-(3,4-dimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 347352-16-3C26H29NO8
Dimethyl 4-(4-chlorophenyl)-1-(4-fluorobenzyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C22H19ClFNO4, CAS 346716-55-0
Dimethyl 4-(4-chlorophenyl)-1-(4-fluorobenzyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 346716-55-0C22H19ClFNO4
Dimethyl 4-(3-hydroxy-4-methoxyphenyl)-1-(4-methoxybenzyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C24H25NO7, CAS 423143-80-0
Dimethyl 4-(3-hydroxy-4-methoxyphenyl)-1-(4-methoxybenzyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 423143-80-0C24H25NO7
Dimethyl 1-(4-chlorobenzyl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C22H19ClFNO4, CAS 423141-32-6
Dimethyl 1-(4-chlorobenzyl)-4-(4-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 423141-32-6C22H19ClFNO4
1-[(4-Fluorophenyl)methyl]-4-(3,4,5-trimethoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester chemical structure, C25H26FNO7, CAS 305865-75-2
1-[(4-Fluorophenyl)methyl]-4-(3,4,5-trimethoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester
CAS 305865-75-2C25H26FNO7
1-[(4-Methylphenyl)methyl]-4-(3,4,5-trimethoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester chemical structure, C26H29NO7, CAS 346714-77-0
1-[(4-Methylphenyl)methyl]-4-(3,4,5-trimethoxyphenyl)-4H-pyridine-3,5-dicarboxylic acid dimethyl ester
CAS 346714-77-0C26H29NO7
Dimethyl 1-benzyl-4-(4-hydroxy-3-methoxyphenyl)-4H-pyridine-3,5-dicarboxylate chemical structure, C23H23NO6, CAS 669736-23-6
Dimethyl 1-benzyl-4-(4-hydroxy-3-methoxyphenyl)-4H-pyridine-3,5-dicarboxylate
CAS 669736-23-6C23H23NO6
Dimethyl 1-(3,4-dimethoxybenzyl)-4-(2,3-dimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C26H29NO8, CAS 347328-88-5
Dimethyl 1-(3,4-dimethoxybenzyl)-4-(2,3-dimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 347328-88-5C26H29NO8
Dimethyl 4-(2,4-dimethoxyphenyl)-1-(4-fluorobenzyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C24H24FNO6, CAS 347312-74-7
Dimethyl 4-(2,4-dimethoxyphenyl)-1-(4-fluorobenzyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 347312-74-7C24H24FNO6
Diethyl 1-(4-fluorobenzyl)-4-(4-hydroxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C24H24FNO5, CAS 832106-03-3
Diethyl 1-(4-fluorobenzyl)-4-(4-hydroxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 832106-03-3C24H24FNO5
Dimethyl 1-benzyl-4-(2,5-dimethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C24H25NO4, CAS 667415-63-6
Dimethyl 1-benzyl-4-(2,5-dimethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 667415-63-6C24H25NO4
Diethyl 1-(4-methoxybenzyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C25H26N2O7, CAS 667415-93-2
Diethyl 1-(4-methoxybenzyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 667415-93-2C25H26N2O7
Dimethyl 1-(2-methoxybenzyl)-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C24H22F3NO5, CAS 694442-51-8
Dimethyl 1-(2-methoxybenzyl)-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 694442-51-8C24H22F3NO5
Dimethyl 1-(4-methoxybenzyl)-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C23H22N2O7, CAS 423140-47-0
Dimethyl 1-(4-methoxybenzyl)-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 423140-47-0C23H22N2O7
Dimethyl 1-(4-chlorobenzyl)-4-(2,4-dimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C24H24ClNO6, CAS 423142-48-7
Dimethyl 1-(4-chlorobenzyl)-4-(2,4-dimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 423142-48-7C24H24ClNO6
Dimethyl 4-(3-chloro-4-hydroxy-5-methoxyphenyl)-1-(4-methoxybenzyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C24H24ClNO7, CAS 423143-08-2
Dimethyl 4-(3-chloro-4-hydroxy-5-methoxyphenyl)-1-(4-methoxybenzyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 423143-08-2C24H24ClNO7
Dimethyl 1-(4-chlorobenzyl)-4-(2,5-dimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C24H24ClNO6, CAS 423139-84-8
Dimethyl 1-(4-chlorobenzyl)-4-(2,5-dimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 423139-84-8C24H24ClNO6
Dimethyl 1-(4-chlorobenzyl)-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C23H19ClF3NO4, CAS 346716-63-0
Dimethyl 1-(4-chlorobenzyl)-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 346716-63-0C23H19ClF3NO4
Dimethyl 1-(4-fluorobenzyl)-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C23H19F4NO4, CAS 346716-34-5
Dimethyl 1-(4-fluorobenzyl)-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 346716-34-5C23H19F4NO4
Dimethyl 1-benzyl-4-(3,4-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate chemical structure, C22H19Cl2NO4, CAS 346714-66-7
Dimethyl 1-benzyl-4-(3,4-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS 346714-66-7C22H19Cl2NO4