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Murcko scaffold

Ring system with 3 rings and 22 atoms

34 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 34
With full pages: 5

Scaffold SMILES

O=C(C=Cc1cnn(-c2ccccc2)c1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(C=Cc1cnn(-c2ccccc2)c1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(3,4-dimethoxyphenyl)prop-2-enamide chemical structure, C22H18ClFN4O3, CAS 956611-41-9

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(3,4-dimethoxyphenyl)prop-2-enamide

CAS 956611-41-9C₂₂H₁₈ClFN₄O₃

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(2-methoxyphenyl)prop-2-enamide chemical structure, C21H16ClFN4O2, CAS 956611-42-0

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(2-methoxyphenyl)prop-2-enamide

CAS 956611-42-0C₂₁H₁₆ClFN₄O₂

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(2-ethoxyphenyl)prop-2-enamide chemical structure, C22H18ClFN4O2, CAS 956040-35-0

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(2-ethoxyphenyl)prop-2-enamide

CAS 956040-35-0C₂₂H₁₈ClFN₄O₂

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-[3-(trifluoromethyl)phenyl]prop-2-enamide chemical structure, C21H13ClF4N4O, CAS 882142-52-1

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-[3-(trifluoromethyl)phenyl]prop-2-enamide

CAS 882142-52-1C₂₁H₁₃ClF₄N₄O

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-N-(3-chloro-4-methoxyphenyl)-2-cyanoprop-2-enamide chemical structure, C21H15Cl2FN4O2, CAS 1164510-76-2

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-N-(3-chloro-4-methoxyphenyl)-2-cyanoprop-2-enamide

CAS 1164510-76-2C₂₁H₁₅Cl₂FN₄O₂

3-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-cyano-N-(2-ethoxyphenyl)prop-2-enamide chemical structure, C22H19ClN4O2, CAS 1164488-00-9

3-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-cyano-N-(2-ethoxyphenyl)prop-2-enamide

CAS 1164488-00-9C₂₂H₁₉ClN₄O₂

(E)-3-(5-Chloro-3-methyl-1-phenylpyrazol-4-yl)-2-cyano-N-(2-methylphenyl)prop-2-enamide chemical structure, C21H17ClN4O, CAS 302945-27-3

(E)-3-(5-Chloro-3-methyl-1-phenylpyrazol-4-yl)-2-cyano-N-(2-methylphenyl)prop-2-enamide

CAS 302945-27-3C₂₁H₁₇ClN₄O

(E)-3-[5-Chloro-1-(4-chlorophenyl)-3-methylpyrazol-4-yl]-2-cyano-N-(3,4-dimethoxyphenyl)prop-2-enamide chemical structure, C22H18Cl2N4O3, CAS 956453-71-7

(E)-3-[5-Chloro-1-(4-chlorophenyl)-3-methylpyrazol-4-yl]-2-cyano-N-(3,4-dimethoxyphenyl)prop-2-enamide

CAS 956453-71-7C₂₂H₁₈Cl₂N₄O₃

(E)-3-[5-Chloro-1-(2-chlorophenyl)-3-methylpyrazol-4-yl]-2-cyano-N-(2,6-diethylphenyl)prop-2-enamide chemical structure, C24H22Cl2N4O, CAS 882226-86-0

(E)-3-[5-Chloro-1-(2-chlorophenyl)-3-methylpyrazol-4-yl]-2-cyano-N-(2,6-diethylphenyl)prop-2-enamide

CAS 882226-86-0C₂₄H₂₂Cl₂N₄O

(E)-3-[5-Chloro-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]-2-cyano-N-(3,4-dimethoxyphenyl)prop-2-enamide chemical structure, C23H18ClF3N4O3, CAS 882238-65-5

(E)-3-[5-Chloro-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]-2-cyano-N-(3,4-dimethoxyphenyl)prop-2-enamide

CAS 882238-65-5C₂₃H₁₈ClF₃N₄O₃

(E)-3-[5-Chloro-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]-2-cyano-N-[4-(difluoromethylsulfanyl)phenyl]prop-2-enamide chemical structure, C22H14ClF5N4OS, CAS 882239-41-0

(E)-3-[5-Chloro-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]-2-cyano-N-[4-(difluoromethylsulfanyl)phenyl]prop-2-enamide

CAS 882239-41-0C₂₂H₁₄ClF₅N₄OS

(E)-3-(5-Chloro-3-methyl-1-phenylpyrazol-4-yl)-2-cyano-N-(4-methoxyphenyl)prop-2-enamide chemical structure, C21H17ClN4O2, CAS 303199-33-9

(E)-3-(5-Chloro-3-methyl-1-phenylpyrazol-4-yl)-2-cyano-N-(4-methoxyphenyl)prop-2-enamide

CAS 303199-33-9C₂₁H₁₇ClN₄O₂

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(2,6-dichlorophenyl)prop-2-enamide chemical structure, C20H12Cl3FN4O, CAS 956239-00-2

3-[5-Chloro-1-(4-fluorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(2,6-dichlorophenyl)prop-2-enamide

CAS 956239-00-2C₂₀H₁₂Cl₃FN₄O

3-[5-Chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(3,4-dimethoxyphenyl)prop-2-enamide chemical structure, C22H18Cl2N4O3, CAS 956236-43-4

3-[5-Chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(3,4-dimethoxyphenyl)prop-2-enamide

CAS 956236-43-4C₂₂H₁₈Cl₂N₄O₃

(E)-3-[5-Chloro-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]-N-[2-chloro-5-(trifluoromethyl)phenyl]-2-cyanoprop-2-enamide chemical structure, C22H12Cl2F6N4O, CAS 956183-60-1

(E)-3-[5-Chloro-3-methyl-1-[3-(trifluoromethyl)phenyl]pyrazol-4-yl]-N-[2-chloro-5-(trifluoromethyl)phenyl]-2-cyanoprop-2-enamide

CAS 956183-60-1C₂₂H₁₂Cl₂F₆N₄O

(E)-3-[5-Chloro-1-(4-fluorophenyl)-3-methylpyrazol-4-yl]-2-cyano-N-(2,6-dimethylphenyl)prop-2-enamide chemical structure, C22H18ClFN4O, CAS 1007640-66-5

(E)-3-[5-Chloro-1-(4-fluorophenyl)-3-methylpyrazol-4-yl]-2-cyano-N-(2,6-dimethylphenyl)prop-2-enamide

CAS 1007640-66-5C₂₂H₁₈ClFN₄O

3-[5-Chloro-1-(2,4-dimethylphenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(2-methylphenyl)prop-2-enamide chemical structure, C23H21ClN4O, CAS 955867-69-3

3-[5-Chloro-1-(2,4-dimethylphenyl)-3-methyl-1H-pyrazol-4-yl]-2-cyano-N-(2-methylphenyl)prop-2-enamide

CAS 955867-69-3C₂₃H₂₁ClN₄O

2-Cyano-N-(2,4-dichlorophenyl)-3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)prop-2-enamide chemical structure, C21H16Cl2N4O, CAS 1005882-17-6

2-Cyano-N-(2,4-dichlorophenyl)-3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)prop-2-enamide

CAS 1005882-17-6C₂₁H₁₆Cl₂N₄O

(2E)-3-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-cyano-N-(2,4,6-trimethylphenyl)-2-propenamide chemical structure, C23H21ClN4O, CAS 1134335-01-5

(2E)-3-(5-Chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-cyano-N-(2,4,6-trimethylphenyl)-2-propenamide

CAS 1134335-01-5C₂₃H₂₁ClN₄O

3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-2-cyano-N-(2-fluorophenyl)prop-2-enamide chemical structure, C19H12ClFN4O, CAS 1181473-98-2

3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-2-cyano-N-(2-fluorophenyl)prop-2-enamide

CAS 1181473-98-2C₁₉H₁₂ClFN₄O

N-(2-Chlorophenyl)-3-[1-(4-chlorophenyl)-1H-pyrazol-4-yl]-2-cyanoprop-2-enamide chemical structure, C19H12Cl2N4O, CAS 1181463-23-9

N-(2-Chlorophenyl)-3-[1-(4-chlorophenyl)-1H-pyrazol-4-yl]-2-cyanoprop-2-enamide

CAS 1181463-23-9C₁₉H₁₂Cl₂N₄O

3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-2-cyano-N-(2,4,6-trimethylphenyl)prop-2-enamide chemical structure, C22H19ClN4O, CAS 1181468-34-7

3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-2-cyano-N-(2,4,6-trimethylphenyl)prop-2-enamide

CAS 1181468-34-7C₂₂H₁₉ClN₄O

3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-2-cyano-N-(2,6-dichlorophenyl)prop-2-enamide chemical structure, C19H11Cl3N4O, CAS 1181479-60-6

3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-2-cyano-N-(2,6-dichlorophenyl)prop-2-enamide

CAS 1181479-60-6C₁₉H₁₁Cl₃N₄O

3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-2-cyano-N-(4-sulfamoylphenyl)prop-2-enamide chemical structure, C19H14ClN5O3S, CAS 1181460-95-6

3-[1-(4-Chlorophenyl)-1H-pyrazol-4-yl]-2-cyano-N-(4-sulfamoylphenyl)prop-2-enamide

CAS 1181460-95-6C₁₉H₁₄ClN₅O₃S