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Murcko scaffold

Ring system with 3 rings and 18 atoms

20 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
20
With full pages
3
Scaffold SMILES

c1ccc(-c2nccc(N3CCCCC3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(-c2nccc(N3CCCCC3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 20 of 20 chemicals

4-Piperidino-2-(2-hydroxyphenyl)pyrimidine chemical structure, C15H17N3O, CAS 75634-06-9
4-Piperidino-2-(2-hydroxyphenyl)pyrimidine
CAS 75634-06-9C15H17N3O
4-Piperidino-6-trifluoromethyl-2-(2-hydroxyphenyl)pyrimidine chemical structure, C16H16F3N3O, CAS 93181-89-6
4-Piperidino-6-trifluoromethyl-2-(2-hydroxyphenyl)pyrimidine
CAS 93181-89-6C16H16F3N3O
4-Methyl-2-phenyl-6-(piperidin-1-yl)pyrimidine chemical structure, C16H19N3, CAS 406189-72-8
4-Methyl-2-phenyl-6-(piperidin-1-yl)pyrimidine
CAS 406189-72-8C16H19N3
Ethyl 2-phenyl-4-(1-piperidinyl)-5-pyrimidinecarboxylate chemical structure, C18H21N3O2, CAS 34753-22-5
Ethyl 2-phenyl-4-(1-piperidinyl)-5-pyrimidinecarboxylate
CAS 34753-22-5C18H21N3O2
4-Chloro-2-phenyl-6-piperidinopyrimidine chemical structure, C15H16ClN3, CAS 574708-35-3
4-Chloro-2-phenyl-6-piperidinopyrimidine
CAS 574708-35-3C15H16ClN3
Methyl (2-phenyl-6-piperidino-4-pyrimidinyl)methyl ether chemical structure, C17H21N3O, CAS 339278-94-3
Methyl (2-phenyl-6-piperidino-4-pyrimidinyl)methyl ether
CAS 339278-94-3C17H21N3O
4-Pyrimidineacetamide, 2-(4-chlorophenyl)-N-hydroxy-6-(1-piperidinyl)- chemical structure, C17H19ClN4O2, CAS 42055-61-8
4-Pyrimidineacetamide, 2-(4-chlorophenyl)-N-hydroxy-6-(1-piperidinyl)-
CAS 42055-61-8C17H19ClN4O2
4-Pyrimidineacetamide, N-hydroxy-6-(1-piperidinyl)-2-(3,4,5-trimethoxyphenyl)- chemical structure, C20H26N4O5, CAS 42055-68-5
4-Pyrimidineacetamide, N-hydroxy-6-(1-piperidinyl)-2-(3,4,5-trimethoxyphenyl)-
CAS 42055-68-5C20H26N4O5
4-Pyrimidineacetamide, 2-(3-chlorophenyl)-N-hydroxy-6-(1-piperidinyl)- chemical structure, C17H19ClN4O2, CAS 42055-74-3
4-Pyrimidineacetamide, 2-(3-chlorophenyl)-N-hydroxy-6-(1-piperidinyl)-
CAS 42055-74-3C17H19ClN4O2
4-Pyrimidineacetamide, N-hydroxy-6-(1-piperidinyl)-2-(3-(trifluoromethyl)phenyl)- chemical structure, C18H19F3N4O2, CAS 42055-80-1
4-Pyrimidineacetamide, N-hydroxy-6-(1-piperidinyl)-2-(3-(trifluoromethyl)phenyl)-
CAS 42055-80-1C18H19F3N4O2
5-Methoxy-2-phenyl-4-piperidinopyrimidine chemical structure, C16H19N3O, CAS 477863-73-3
5-Methoxy-2-phenyl-4-piperidinopyrimidine
CAS 477863-73-3C16H19N3O
2-[4-Methyl-6-(2-methylpiperidin-1-yl)pyrimidin-2-yl]phenol chemical structure, C17H21N3O, CAS 552286-06-3
2-[4-Methyl-6-(2-methylpiperidin-1-yl)pyrimidin-2-yl]phenol
CAS 552286-06-3C17H21N3O
2-Phenyl-4-(piperidin-1-yl)pyrimidine-5-carbonitrile chemical structure, C16H16N4, CAS 823796-07-2
2-Phenyl-4-(piperidin-1-yl)pyrimidine-5-carbonitrile
CAS 823796-07-2C16H16N4
5-Bromo-2-phenyl-4-(piperidin-1-yl)pyrimidine chemical structure, C15H16BrN3, CAS 823796-02-7
5-Bromo-2-phenyl-4-(piperidin-1-yl)pyrimidine
CAS 823796-02-7C15H16BrN3
5-Chloro-2-phenyl-4-(piperidin-1-yl)pyrimidine chemical structure, C15H16ClN3, CAS 26740-79-4
5-Chloro-2-phenyl-4-(piperidin-1-yl)pyrimidine
CAS 26740-79-4C15H16ClN3
4-(2-Methylpiperidin-1-yl)-2-phenylpyrimidine-5-carbonitrile chemical structure, C17H18N4, CAS 823796-26-5
4-(2-Methylpiperidin-1-yl)-2-phenylpyrimidine-5-carbonitrile
CAS 823796-26-5C17H18N4
1-(2-(4-Isopropoxy-3-isopropylphenyl)pyrimidin-4-yl)piperidin-4-amine chemical structure, C21H30N4O, CAS 1378366-45-0
1-(2-(4-Isopropoxy-3-isopropylphenyl)pyrimidin-4-yl)piperidin-4-amine
CAS 1378366-45-0C21H30N4O
1-[6-(Methoxymethyl)-2-phenyl-4-pyrimidinyl]-4-piperidinemethanamine chemical structure, C18H24N4O, CAS 1239748-55-0
1-[6-(Methoxymethyl)-2-phenyl-4-pyrimidinyl]-4-piperidinemethanamine
CAS 1239748-55-0C18H24N4O
[1-(6-Chloro-5-ethyl-2-phenylpyrimidin-4-yl)piperidin-4-yl]methanesulfonamide chemical structure, C18H23ClN4O2S, CAS 1394723-54-6
[1-(6-Chloro-5-ethyl-2-phenylpyrimidin-4-yl)piperidin-4-yl]methanesulfonamide
CAS 1394723-54-6C18H23ClN4O2S
6-[5-Butanoyl-6-(piperidin-1-yl)pyrimidin-2(1H)-ylidene]cyclohexa-2,4-dien-1-one chemical structure, C19H23N3O2, CAS 823792-40-1
6-[5-Butanoyl-6-(piperidin-1-yl)pyrimidin-2(1H)-ylidene]cyclohexa-2,4-dien-1-one
CAS 823792-40-1C19H23N3O2