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Murcko scaffold

Ring system with 4 rings and 24 atoms

34 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
34
With full pages
3
Scaffold SMILES

O=C(c1cc(-c2ccccc2)nc2ccccc12)N1CCNCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1cc(-c2ccccc2)nc2ccccc12)N1CCNCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

Methanone, (4-methyl-1-piperazinyl)(2-phenyl-4-quinolinyl)- chemical structure, C21H21N3O, CAS 349400-37-9
Methanone, (4-methyl-1-piperazinyl)(2-phenyl-4-quinolinyl)-
CAS 349400-37-9C21H21N3O
[2-(3-Methylphenyl)quinolin-4-yl]-(4-methylpiperazin-1-yl)methanone chemical structure, C22H23N3O, CAS 352677-78-2
[2-(3-Methylphenyl)quinolin-4-yl]-(4-methylpiperazin-1-yl)methanone
CAS 352677-78-2C22H23N3O
2-(4-Methoxyphenyl)-4-[(4-methyl-1-piperazinyl)carbonyl]quinoline chemical structure, C22H23N3O2, CAS 353767-17-6
2-(4-Methoxyphenyl)-4-[(4-methyl-1-piperazinyl)carbonyl]quinoline
CAS 353767-17-6C22H23N3O2
tert-Butyl 4-[6-bromo-2-(3-methylphenyl)quinoline-4-carbonyl]piperazine-1-carboxylate chemical structure, C26H28BrN3O3, CAS 445260-09-3
tert-Butyl 4-[6-bromo-2-(3-methylphenyl)quinoline-4-carbonyl]piperazine-1-carboxylate
CAS 445260-09-3C26H28BrN3O3
4-{[4-(Methylsulfonyl)-1-piperazinyl]carbonyl}-2-phenylquinoline chemical structure, C21H21N3O3S, CAS 713489-72-6
4-{[4-(Methylsulfonyl)-1-piperazinyl]carbonyl}-2-phenylquinoline
CAS 713489-72-6C21H21N3O3S
[2-(4-Ethylphenyl)quinolin-4-yl]-(4-methylpiperazin-1-yl)methanone chemical structure, C23H25N3O, CAS 389080-57-3
[2-(4-Ethylphenyl)quinolin-4-yl]-(4-methylpiperazin-1-yl)methanone
CAS 389080-57-3C23H25N3O
[2-(3-Bromophenyl)-6-methylquinolin-4-yl]-(4-methylpiperazin-1-yl)methanone chemical structure, C22H22BrN3O, CAS 713114-74-0
[2-(3-Bromophenyl)-6-methylquinolin-4-yl]-(4-methylpiperazin-1-yl)methanone
CAS 713114-74-0C22H22BrN3O
[2-(4-Fluorophenyl)quinolin-4-yl](4-methylpiperazin-1-yl)methanone chemical structure, C21H20FN3O, CAS 327976-35-2
[2-(4-Fluorophenyl)quinolin-4-yl](4-methylpiperazin-1-yl)methanone
CAS 327976-35-2C21H20FN3O
[2-(3,4-Dimethoxyphenyl)-4-quinolyl](4-methylpiperazino)methanone chemical structure, C23H25N3O3, CAS 419558-65-9
[2-(3,4-Dimethoxyphenyl)-4-quinolyl](4-methylpiperazino)methanone
CAS 419558-65-9C23H25N3O3
[2-(2-Chlorophenyl)-6-methylquinolin-4-yl]-(4-propylpiperazin-1-yl)methanone chemical structure, C24H26ClN3O, CAS 713119-48-3
[2-(2-Chlorophenyl)-6-methylquinolin-4-yl]-(4-propylpiperazin-1-yl)methanone
CAS 713119-48-3C24H26ClN3O
Ethyl 4-[2-(4-methoxyphenyl)quinoline-4-carbonyl]piperazine-1-carboxylate chemical structure, C24H25N3O4, CAS 915910-98-4
Ethyl 4-[2-(4-methoxyphenyl)quinoline-4-carbonyl]piperazine-1-carboxylate
CAS 915910-98-4C24H25N3O4
Ethyl 4-[2-(3,4-dimethoxyphenyl)quinoline-4-carbonyl]piperazine-1-carboxylate chemical structure, C25H27N3O5, CAS 748145-64-4
Ethyl 4-[2-(3,4-dimethoxyphenyl)quinoline-4-carbonyl]piperazine-1-carboxylate
CAS 748145-64-4C25H27N3O5
[2-(4-Ethylphenyl)-6-methylquinolin-4-yl]-(4-ethylpiperazin-1-yl)methanone chemical structure, C25H29N3O, CAS 588697-22-7
[2-(4-Ethylphenyl)-6-methylquinolin-4-yl]-(4-ethylpiperazin-1-yl)methanone
CAS 588697-22-7C25H29N3O
[2-(4-Chlorophenyl)-4-quinolyl](4-methylpiperazino)methanone chemical structure, C21H20ClN3O, CAS 354546-30-8
[2-(4-Chlorophenyl)-4-quinolyl](4-methylpiperazino)methanone
CAS 354546-30-8C21H20ClN3O
tert-Butyl 4-(6-bromo-2-(4-chlorophenyl)quinoline-4-carbonyl)piperazine-1-carboxylate chemical structure, C25H25BrClN3O3, CAS 438229-45-9
tert-Butyl 4-(6-bromo-2-(4-chlorophenyl)quinoline-4-carbonyl)piperazine-1-carboxylate
CAS 438229-45-9C25H25BrClN3O3
Ethyl 4-(2-(3,4-dimethylphenyl)-6-methylquinoline-4-carbonyl)piperazine-1-carboxylate chemical structure, C26H29N3O3, CAS 724757-99-7
Ethyl 4-(2-(3,4-dimethylphenyl)-6-methylquinoline-4-carbonyl)piperazine-1-carboxylate
CAS 724757-99-7C26H29N3O3
(4-Ethylpiperazin-1-yl)-[2-(3-methoxyphenyl)quinolin-4-yl]methanone chemical structure, C23H25N3O2, CAS 6367-44-8
(4-Ethylpiperazin-1-yl)-[2-(3-methoxyphenyl)quinolin-4-yl]methanone
CAS 6367-44-8C23H25N3O2
[2-(4-Methoxyphenyl)-4-quinolyl][4-(methylsulfonyl)piperazino]methanone chemical structure, C22H23N3O4S, CAS 955269-19-9
[2-(4-Methoxyphenyl)-4-quinolyl][4-(methylsulfonyl)piperazino]methanone
CAS 955269-19-9C22H23N3O4S
[7-Chloro-2-(4-ethylphenyl)-8-methylquinolin-4-yl](4-methylpiperazin-1-yl)methanone chemical structure, C24H26ClN3O, CAS 669704-92-1
[7-Chloro-2-(4-ethylphenyl)-8-methylquinolin-4-yl](4-methylpiperazin-1-yl)methanone
CAS 669704-92-1C24H26ClN3O
[2-(2,5-Dimethylphenyl)-8-methylquinolin-4-yl](4-propylpiperazin-1-yl)methanone chemical structure, C26H31N3O, CAS 669709-62-0
[2-(2,5-Dimethylphenyl)-8-methylquinolin-4-yl](4-propylpiperazin-1-yl)methanone
CAS 669709-62-0C26H31N3O
[2-(3,4-Dimethylphenyl)-6-methylquinolin-4-yl](4-methylpiperazin-1-yl)methanone chemical structure, C24H27N3O, CAS 669728-79-4
[2-(3,4-Dimethylphenyl)-6-methylquinolin-4-yl](4-methylpiperazin-1-yl)methanone
CAS 669728-79-4C24H27N3O
Ethyl 4-{[2-(3,4-dimethylphenyl)-8-methylquinolin-4-yl]carbonyl}piperazine-1-carboxylate chemical structure, C26H29N3O3, CAS 724750-15-6
Ethyl 4-{[2-(3,4-dimethylphenyl)-8-methylquinolin-4-yl]carbonyl}piperazine-1-carboxylate
CAS 724750-15-6C26H29N3O3
[2-(3-Chlorophenyl)quinolin-4-yl][4-(methylsulfonyl)piperazin-1-yl]methanone chemical structure, C21H20ClN3O3S, CAS 724760-05-8
[2-(3-Chlorophenyl)quinolin-4-yl][4-(methylsulfonyl)piperazin-1-yl]methanone
CAS 724760-05-8C21H20ClN3O3S
6-Methyl-2-phenyl-4-[4-(prop-2-yn-1-yl)piperazine-1-carbonyl]quinoline chemical structure, C24H23N3O, CAS 941376-85-8
6-Methyl-2-phenyl-4-[4-(prop-2-yn-1-yl)piperazine-1-carbonyl]quinoline
CAS 941376-85-8C24H23N3O