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Murcko scaffold

Ring system with 4 rings and 26 atoms

278 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 26
Chemicals: 278
With full pages: 3

Scaffold SMILES

O=C1N(Cc2ccccc2)c2ccccc2S(=O)(=O)N1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1N(Cc2ccccc2)c2ccccc2S(=O)(=O)N1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 278 chemicals

2-(4-Chlorophenyl)-4-(3-fluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C20H14ClFN2O3S, CAS 866845-61-6

2-(4-Chlorophenyl)-4-(3-fluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 866845-61-6C₂₀H₁₄ClFN₂O₃S

2-(4-Chlorophenyl)-4-(2-methylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C21H17ClN2O3S, CAS 866845-62-7

2-(4-Chlorophenyl)-4-(2-methylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 866845-62-7C₂₁H₁₇ClN₂O₃S

4-(4-Chlorobenzyl)-2-(4-methoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C21H17ClN2O4S, CAS 866846-92-6

4-(4-Chlorobenzyl)-2-(4-methoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 866846-92-6C₂₁H₁₇ClN₂O₄S

2-(4-Chlorophenyl)-4-(3-nitrobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C20H14ClN3O5S, CAS 866843-46-1

2-(4-Chlorophenyl)-4-(3-nitrobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 866843-46-1C₂₀H₁₄ClN₃O₅S

4-(2-Chloro-6-fluorobenzyl)-2-(4-chlorophenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C20H13Cl2FN2O3S, CAS 866864-56-4

4-(2-Chloro-6-fluorobenzyl)-2-(4-chlorophenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 866864-56-4C₂₀H₁₃Cl₂FN₂O₃S

4-Benzyl-2-(3-chloro-4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C21H17ClN2O3S, CAS 866864-58-6

4-Benzyl-2-(3-chloro-4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 866864-58-6C₂₁H₁₇ClN₂O₃S

4-(2-Chloro-6-fluorobenzyl)-2-(3-chloro-4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C21H15Cl2FN2O3S, CAS 866866-79-7

4-(2-Chloro-6-fluorobenzyl)-2-(3-chloro-4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 866866-79-7C₂₁H₁₅Cl₂FN₂O₃S

2-(3-Chloro-4-methylphenyl)-4-(3-nitrobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C21H16ClN3O5S, CAS 866867-48-3

2-(3-Chloro-4-methylphenyl)-4-(3-nitrobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 866867-48-3C₂₁H₁₆ClN₃O₅S

4-(2-Chlorobenzyl)-2-(4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C21H17ClN2O3S, CAS 872207-24-4

4-(2-Chlorobenzyl)-2-(4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 872207-24-4C₂₁H₁₇ClN₂O₃S

4-(2-Chloro-6-fluorobenzyl)-2-(4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C21H16ClFN2O3S, CAS 872207-26-6

4-(2-Chloro-6-fluorobenzyl)-2-(4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 872207-26-6C₂₁H₁₆ClFN₂O₃S

4-(3-Fluorobenzyl)-2-(4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C21H17FN2O3S, CAS 872207-27-7

4-(3-Fluorobenzyl)-2-(4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 872207-27-7C₂₁H₁₇FN₂O₃S

4-(2,5-Dimethylbenzyl)-2-(4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C23H22N2O3S, CAS 872207-31-3

4-(2,5-Dimethylbenzyl)-2-(4-methylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 872207-31-3C₂₃H₂₂N₂O₃S

4-(2,5-Dimethylbenzyl)-2-(3,5-dimethylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C24H24N2O3S, CAS 872207-36-8

4-(2,5-Dimethylbenzyl)-2-(3,5-dimethylphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 872207-36-8C₂₄H₂₄N₂O₃S

4-(2,5-Dimethylbenzyl)-2-phenyl-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C22H20N2O3S, CAS 872208-66-7

4-(2,5-Dimethylbenzyl)-2-phenyl-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 872208-66-7C₂₂H₂₀N₂O₃S

4-(4-Chlorobenzyl)-2-(3,5-dimethoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C22H19ClN2O5S, CAS 867040-79-7

4-(4-Chlorobenzyl)-2-(3,5-dimethoxyphenyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 867040-79-7C₂₂H₁₉ClN₂O₅S

2-(4-Ethoxyphenyl)-4-(2-methylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C23H22N2O4S, CAS 867040-80-0

2-(4-Ethoxyphenyl)-4-(2-methylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 867040-80-0C₂₃H₂₂N₂O₄S

2-(4-Ethoxyphenyl)-4-(4-methylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C23H22N2O4S, CAS 867040-81-1

2-(4-Ethoxyphenyl)-4-(4-methylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 867040-81-1C₂₃H₂₂N₂O₄S

2-(3,5-Dimethylphenyl)-4-(3-fluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C22H19FN2O3S, CAS 872206-28-5

2-(3,5-Dimethylphenyl)-4-(3-fluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 872206-28-5C₂₂H₁₉FN₂O₃S

2-(4-Acetylphenyl)-4-benzyl-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C22H18N2O4S, CAS 895640-93-4

2-(4-Acetylphenyl)-4-benzyl-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 895640-93-4C₂₂H₁₈N₂O₄S

4-(3-Chlorobenzyl)-2-phenyl-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C20H15ClN2O3S, CAS 895644-35-6

4-(3-Chlorobenzyl)-2-phenyl-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 895644-35-6C₂₀H₁₅ClN₂O₃S

2-(2-Ethylphenyl)-4-(2-methylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C23H22N2O3S, CAS 895650-38-1

2-(2-Ethylphenyl)-4-(2-methylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 895650-38-1C₂₃H₂₂N₂O₃S

2-(3-Chlorophenyl)-4-(2-methylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C21H17ClN2O3S, CAS 899976-23-9

2-(3-Chlorophenyl)-4-(2-methylbenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 899976-23-9C₂₁H₁₇ClN₂O₃S

2-(2,5-Dimethylphenyl)-4-(4-fluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide chemical structure, C22H19FN2O3S, CAS 896685-13-5

2-(2,5-Dimethylphenyl)-4-(4-fluorobenzyl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide

CAS 896685-13-5C₂₂H₁₉FN₂O₃S

4-((2-(2,5-Dimethylphenyl)-1,1-dioxido-3-oxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)methyl)benzonitrile chemical structure, C23H19N3O3S, CAS 896685-25-9

4-((2-(2,5-Dimethylphenyl)-1,1-dioxido-3-oxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)methyl)benzonitrile

CAS 896685-25-9C₂₃H₁₉N₃O₃S