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Murcko scaffold

3-Phenylphthalide scaffold

92 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
92
With full pages
12
Scaffold SMILES

O=C1OC(c2ccccc2)c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Phenylphthalide page
Murcko scaffold O=C1OC(c2ccccc2)c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 92 chemicals

3-(tert-Butyldioxy)-3-phenylphthalide chemical structure, C18H18O4, CAS 25251-51-8
3-(tert-Butyldioxy)-3-phenylphthalide
CAS 25251-51-8C18H18O4
1(3H)-Isobenzofuranone, 6-(dimethylamino)-3-[4-(dimethylamino)phenyl]- chemical structure, C18H20N2O2, CAS 57515-95-4
1(3H)-Isobenzofuranone, 6-(dimethylamino)-3-[4-(dimethylamino)phenyl]-
CAS 57515-95-4C18H20N2O2
3-Phenylphthalide chemical structure, C14H10O2, CAS 5398-11-8
3-Phenylphthalide
CAS 5398-11-8C14H10O2
LU 3-017 chemical structure, C19H22ClNO2, CAS 10589-00-1
LU 3-017
CAS 10589-00-1C19H22ClNO2
Ici 53165 chemical structure, C19H21NO2, CAS 37401-68-6
Ici 53165
CAS 37401-68-6C19H21NO2
3-(tert-Butyldioxy)-3-(4-chlorophenyl)phthalide chemical structure, C18H17ClO4, CAS 30723-78-5
3-(tert-Butyldioxy)-3-(4-chlorophenyl)phthalide
CAS 30723-78-5C18H17ClO4
3-(3,5-Dibromo-4-hydroxyphenyl)-2-benzofuran-1(3H)-one chemical structure, C14H8Br2O3, CAS 6315-30-6
3-(3,5-Dibromo-4-hydroxyphenyl)-2-benzofuran-1(3H)-one
CAS 6315-30-6C14H8Br2O3
3-Oxo-1-phenyl-1,3-dihydro-2-benzofuran-1-carboxamide chemical structure, C15H11NO3, CAS 6319-77-3
3-Oxo-1-phenyl-1,3-dihydro-2-benzofuran-1-carboxamide
CAS 6319-77-3C15H11NO3
3-Methyl-3-phenylphthalide chemical structure, C15H12O2, CAS 18019-56-2
3-Methyl-3-phenylphthalide
CAS 18019-56-2C15H12O2
3-(3,4-Dimethoxyphenyl)-3H-2-benzofuran-1-one chemical structure, C16H14O4, CAS 37618-00-1
3-(3,4-Dimethoxyphenyl)-3H-2-benzofuran-1-one
CAS 37618-00-1C16H14O4
3-Methoxy-3-phenyl-2-benzofuran-1(3H)-one chemical structure, C15H12O3, CAS 7335-63-9
3-Methoxy-3-phenyl-2-benzofuran-1(3H)-one
CAS 7335-63-9C15H12O3
3-Methoxy-4,7-dimethyl-3-phenyl-2-benzofuran-1(3H)-one chemical structure, C17H16O3, CAS 72181-93-2
3-Methoxy-4,7-dimethyl-3-phenyl-2-benzofuran-1(3H)-one
CAS 72181-93-2C17H16O3
3-Isopropoxy-3-phenyl-2-benzofuran-1(3H)-one chemical structure, C17H16O3, CAS 15222-33-0
3-Isopropoxy-3-phenyl-2-benzofuran-1(3H)-one
CAS 15222-33-0C17H16O3
(4-Methyl-3-oxo-1-phenyl-1,3-dihydro-2-benzofuran-1-yl)acetic acid chemical structure, C17H14O4, CAS 24766-47-0
(4-Methyl-3-oxo-1-phenyl-1,3-dihydro-2-benzofuran-1-yl)acetic acid
CAS 24766-47-0C17H14O4
(4,7-Dimethyl-3-oxo-1-phenyl-1,3-dihydro-2-benzofuran-1-yl)acetic acid chemical structure, C18H16O4, CAS 24766-48-1
(4,7-Dimethyl-3-oxo-1-phenyl-1,3-dihydro-2-benzofuran-1-yl)acetic acid
CAS 24766-48-1C18H16O4
Ethyl (3-oxo-1-phenyl-1,3-dihydro-2-benzofuran-1-yl)acetate chemical structure, C18H16O4, CAS 6158-57-2
Ethyl (3-oxo-1-phenyl-1,3-dihydro-2-benzofuran-1-yl)acetate
CAS 6158-57-2C18H16O4
3-(4-Hydroxyphenyl)-2-benzofuran-1(3H)-one chemical structure, C14H10O3, CAS 7468-76-0
3-(4-Hydroxyphenyl)-2-benzofuran-1(3H)-one
CAS 7468-76-0C14H10O3
3-(2-Methoxyphenyl)-2-benzofuran-1(3H)-one chemical structure, C15H12O3, CAS 7472-96-0
3-(2-Methoxyphenyl)-2-benzofuran-1(3H)-one
CAS 7472-96-0C15H12O3
3-Ethoxy-3-phenyl-2-benzofuran-1(3H)-one chemical structure, C16H14O3, CAS 7498-89-7
3-Ethoxy-3-phenyl-2-benzofuran-1(3H)-one
CAS 7498-89-7C16H14O3
1(3H)-Isobenzofuranone, 3-methoxy-7-methyl-3-(2-methylphenyl)- chemical structure, C17H16O3, CAS 7504-12-3
1(3H)-Isobenzofuranone, 3-methoxy-7-methyl-3-(2-methylphenyl)-
CAS 7504-12-3C17H16O3
3-(2-Methylphenyl)phthalide chemical structure, C15H12O2, CAS 90445-44-6
3-(2-Methylphenyl)phthalide
CAS 90445-44-6C15H12O2
Ethyl 2-(3-oxo-1-phenyl-1,3-dihydro-2-benzofuran-1-yl)propanoate chemical structure, C19H18O4, CAS 30715-59-4
Ethyl 2-(3-oxo-1-phenyl-1,3-dihydro-2-benzofuran-1-yl)propanoate
CAS 30715-59-4C19H18O4
2-(3-Oxo-1,3-dihydro-2-benzofuran-1-yl)benzoic acid chemical structure, C15H10O4, CAS 109407-76-3
2-(3-Oxo-1,3-dihydro-2-benzofuran-1-yl)benzoic acid
CAS 109407-76-3C15H10O4
3-Butoxy-3-phenyl-2-benzofuran-1(3H)-one chemical structure, C18H18O3, CAS 296877-49-1
3-Butoxy-3-phenyl-2-benzofuran-1(3H)-one
CAS 296877-49-1C18H18O3