Murcko scaffold
N-(2-Phenylethyl)-2-thiophenecarboxamide scaffold
56 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 16
- Chemicals
- 56
- With full pages
- 11
Scaffold SMILES
O=C(NCCc1ccccc1)c1cccs1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 56 chemicals
l-Phenylalanine, N-(2-thienylcarbonyl)-, methyl ester
CAS 83851-72-3C15H15NO3S
![N-[2-(4-Fluorophenyl)ethyl]thiophene-2-carboxamide chemical structure, C13H12FNOS, CAS 505081-27-6](/s/BXAAUOBCGBLGIW-UHFFFAOYSA-N.svg)
N-[2-(4-Fluorophenyl)ethyl]thiophene-2-carboxamide
CAS 505081-27-6C13H12FNOS
N-(2-Phenylethyl)-2-thiophenecarboxamide
CAS 75690-78-7C13H13NOS
![N-[2-(3,4-Diethoxyphenyl)ethyl]thiophene-2-carboxamide chemical structure, C17H21NO3S, CAS 447448-72-8](/s/PWAJDMSZGVJSQE-UHFFFAOYSA-N.svg)
N-[2-(3,4-Diethoxyphenyl)ethyl]thiophene-2-carboxamide
CAS 447448-72-8C17H21NO3S
![N-[2-(3-Chlorophenyl)ethyl]thiophene-2-carboxamide chemical structure, C13H12ClNOS, CAS 560089-49-8](/s/RZBKSZLVZLQKTD-UHFFFAOYSA-N.svg)
N-[2-(3-Chlorophenyl)ethyl]thiophene-2-carboxamide
CAS 560089-49-8C13H12ClNOS
![5-Bromo-N-[2-(4-sulfamoylphenyl)ethyl]thiophene-2-carboxamide chemical structure, C13H13BrN2O3S2, CAS 777873-01-5](/s/PWLILFBITMXNKE-UHFFFAOYSA-N.svg)
5-Bromo-N-[2-(4-sulfamoylphenyl)ethyl]thiophene-2-carboxamide
CAS 777873-01-5C13H13BrN2O3S2
![5-Chloro-N-[2-(4-sulfamoylphenyl)ethyl]thiophene-2-carboxamide chemical structure, C13H13ClN2O3S2, CAS 91762-49-1](/s/QOICNTQQXOZTIT-UHFFFAOYSA-N.svg)
5-Chloro-N-[2-(4-sulfamoylphenyl)ethyl]thiophene-2-carboxamide
CAS 91762-49-1C13H13ClN2O3S2
![N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-methylthiophene-2-carboxamide chemical structure, C16H19NO3S, CAS 717870-46-7](/s/GZCOUEWCCGNMLO-UHFFFAOYSA-N.svg)
N-[2-(3,4-Dimethoxyphenyl)ethyl]-5-methylthiophene-2-carboxamide
CAS 717870-46-7C16H19NO3S
![N-[2-(3,4-Dimethoxyphenyl)ethyl]thiophene-2-carboxamide chemical structure, C15H17NO3S, CAS 98215-46-4](/s/GTGJRYCDRSYMBB-UHFFFAOYSA-N.svg)
N-[2-(3,4-Dimethoxyphenyl)ethyl]thiophene-2-carboxamide
CAS 98215-46-4C15H17NO3S
Methyl 2-amino-4-methyl-5-(phenethylcarbamoyl)thiophene-3-carboxylate
CAS 831251-44-6C16H18N2O3S
N-(2-Phenylpropyl)thiophene-2-carboxamide
CAS 6043-44-3C14H15NOS
3-Phenyl-2-((thiophen-2-yl)formamido)propanoic acid
CAS 1803030-67-2C14H13NO3S
![N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-methylthiophene-2-carboxamide chemical structure, C16H19NO3S, CAS 1023537-11-2](/s/SPXQQFNMHIAIBR-UHFFFAOYSA-N.svg)
N-[2-(3,4-Dimethoxyphenyl)ethyl]-3-methylthiophene-2-carboxamide
CAS 1023537-11-2C16H19NO3S
![N-[1,3-Dihydroxy-1-(4-nitrophenyl)propan-2-yl]thiophene-2-carboxamide chemical structure, C14H14N2O5S, CAS 695206-12-3](/s/PRIVOAVAFMUNKE-UHFFFAOYSA-N.svg)
N-[1,3-Dihydroxy-1-(4-nitrophenyl)propan-2-yl]thiophene-2-carboxamide
CAS 695206-12-3C14H14N2O5S
![4-[(Diethylamino)sulfonyl]-N-(2-phenylethyl)-2-thiophenecarboxamide chemical structure, C17H22N2O3S2, CAS 352673-13-3](/s/KUCMDFUWTFVAIA-UHFFFAOYSA-N.svg)
4-[(Diethylamino)sulfonyl]-N-(2-phenylethyl)-2-thiophenecarboxamide
CAS 352673-13-3C17H22N2O3S2
![5-Chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]thiophene-2-carboxamide chemical structure, C15H16ClNO3S, CAS 98215-47-5](/s/TWWADHFBZKWONW-UHFFFAOYSA-N.svg)
5-Chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]thiophene-2-carboxamide
CAS 98215-47-5C15H16ClNO3S
N-(4-(Dimethylamino)phenethyl)thiophene-2-carboxamide
CAS 952966-90-4C15H18N2OS
5-Acetyl-N-(2-phenylethyl)-2-thiophenecarboxamide
CAS 925920-52-1C15H15NO2S
N-(3,3,3-Trifluoro-2-hydroxy-2-phenylpropyl)thiophene-2-carboxamide
CAS 1351630-92-6C14H12F3NO2S
N-(2-Hydroxy-2-phenylpropyl)-4-methylthiophene-2-carboxamide
CAS 1351635-12-5C15H17NO2S
5-Chloro-N-(2-hydroxy-2-phenylpropyl)thiophene-2-carboxamide
CAS 1351659-81-8C14H14ClNO2S
N-(2-Hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)-4-methylthiophene-2-carboxamide
CAS 1351621-76-5C15H14F3NO2S
![5-Chloro-N-{2-hydroxy-2-[4-(trifluoromethyl)phenyl]ethyl}thiophene-2-carboxamide chemical structure, C14H11ClF3NO2S, CAS 1351635-50-1](/s/DWIANIQUTKDLNG-UHFFFAOYSA-N.svg)
5-Chloro-N-{2-hydroxy-2-[4-(trifluoromethyl)phenyl]ethyl}thiophene-2-carboxamide
CAS 1351635-50-1C14H11ClF3NO2S
![N-{2-[4-(Dimethylamino)phenyl]-2-hydroxyethyl}thiophene-2-carboxamide chemical structure, C15H18N2O2S, CAS 1421529-15-8](/s/WYXUUPNUKYSDTL-UHFFFAOYSA-N.svg)
N-{2-[4-(Dimethylamino)phenyl]-2-hydroxyethyl}thiophene-2-carboxamide
CAS 1421529-15-8C15H18N2O2S
- N-(2-Hydroxy-2-(4-(methylthio)phenyl)ethyl)thiophene-2-carboxamide1448135-95-2C14H15NO2S2
- 4-Bromo-N-(2-hydroxy-2-(4-(methylthio)phenyl)ethyl)thiophene-2-carboxamide1448058-11-4C14H14BrNO2S2
- N-(2-Methoxy-2-(o-tolyl)ethyl)thiophene-2-carboxamide1797641-02-1C15H17NO2S
- 5-Chloro-N-(2-methoxy-2-(o-tolyl)ethyl)thiophene-2-carboxamide1448131-80-3C15H16ClNO2S
- 4-Bromo-N-(2-methoxy-2-(o-tolyl)ethyl)thiophene-2-carboxamide1797892-77-3C15H16BrNO2S
- N-[2-(2-Fluorophenyl)-2-methoxypropyl]thiophene-2-carboxamide1796950-48-5C15H16FNO2S
- 5-Chloro-N-[2-(2-fluorophenyl)-2-methoxypropyl]thiophene-2-carboxamide1797183-99-3C15H15ClFNO2S
- 5-Chloro-N-(2-methoxy-2-phenylbutyl)thiophene-2-carboxamide1798039-36-7C16H18ClNO2S
- 4-Bromo-N-(2-methoxy-2-phenylbutyl)thiophene-2-carboxamide1797339-67-3C16H18BrNO2S
- N-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-methylthiophene-2-carboxamide1797601-17-2C16H19NO4S
- 4-Bromo-N-[2-(3,4-dimethoxyphenyl)-2-hydroxyethyl]thiophene-2-carboxamide1797762-27-6C15H16BrNO4S
- N-[2-(3-Fluorophenyl)-2-methoxyethyl]-4-methylthiophene-2-carboxamide1797159-73-9C15H16FNO2S
- 5-Chloro-N-[2-(3-fluorophenyl)-2-methoxyethyl]thiophene-2-carboxamide1797876-40-4C14H13ClFNO2S
- 4-Bromo-N-[2-(3-fluorophenyl)-2-methoxyethyl]thiophene-2-carboxamide1797876-73-3C14H13BrFNO2S
- 5-Chloro-N-[2-methoxy-2-(3-methoxyphenyl)ethyl]thiophene-2-carboxamide1797879-43-6C15H16ClNO3S
- N-(2-(2-Hydroxyethoxy)-2-(p-tolyl)ethyl)-4-methylthiophene-2-carboxamide1795191-00-2C17H21NO3S
- 5-Chloro-N-(2-(2-hydroxyethoxy)-2-(p-tolyl)ethyl)thiophene-2-carboxamide1795191-04-6C16H18ClNO3S
- 4-Bromo-N-{2-hydroxy-2-[4-(trifluoromethyl)phenyl]ethyl}thiophene-2-carboxamide1788542-77-7C14H11BrF3NO2S
- N-[2-Methoxy-2-(2-methoxyphenyl)ethyl]thiophene-2-carboxamide1798659-36-5C15H17NO3S
- 5-Chloro-N-[2-methoxy-2-(2-methoxyphenyl)ethyl]thiophene-2-carboxamide1788558-12-2C15H16ClNO3S
- 4-Bromo-N-[2-methoxy-2-(2-methoxyphenyl)ethyl]thiophene-2-carboxamide1788558-29-1C15H16BrNO3S
- N-[2-Methoxy-2-(3-methoxyphenyl)ethyl]thiophene-2-carboxamide1797557-54-0C15H17NO3S
- N-[2-(2-Chlorophenyl)-2-methoxyethyl]thiophene-2-carboxamide1795442-24-8C14H14ClNO2S
- 5-Chloro-N-[2-(2-chlorophenyl)-2-methoxyethyl]thiophene-2-carboxamide1795485-16-3C14H13Cl2NO2S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nnc[nH]1)Nc1ccccc1](/scaffold/VJBDIQRNSVRUDP-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc[nH]1)Nc1ccccc165 chemicals
O=C(COc1ccccc1)Nc1nccs143 chemicals
O=C(CCc1ccco1)Nc1ccccc134 chemicals
O=C(CSc1nncs1)Nc1ccccc134 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc[nH]n1](/scaffold/UEBQXDJERRSAMF-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc[nH]n129 chemicals
O=C(CCc1ccccc1)Nc1nncs125 chemicals
S=C(NCc1ccco1)Nc1ccccc124 chemicals![Scaffold O=C(CSc1nnn[nH]1)Nc1ccccc1](/scaffold/FDRBWKCIVMSABC-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnn[nH]1)Nc1ccccc122 chemicals![Scaffold O=C(CSc1ncc[nH]1)Nc1ccccc1](/scaffold/OMOYRSCPUXAYDW-UHFFFAOYSA-N/structure.svg)
O=C(CSc1ncc[nH]1)Nc1ccccc121 chemicals
O=C(NC(=S)Nc1ccccc1)c1ccco121 chemicals
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O=C(NN=Cc1ccco1)c1ccccc119 chemicals