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Murcko scaffold

1-(Phenylacetyl)-4-(phenylsulfonyl)piperazine scaffold

14 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
14
With full pages
5
Scaffold SMILES

O=C(Cc1ccccc1)N1CCN(S(=O)(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(Phenylacetyl)-4-(phenylsulfonyl)piperazine page
Murcko scaffold O=C(Cc1ccccc1)N1CCN(S(=O)(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 14 of 14 chemicals

1-(Phenylacetyl)-4-(phenylsulfonyl)piperazine chemical structure, C18H20N2O3S, CAS 522650-58-4
1-(Phenylacetyl)-4-(phenylsulfonyl)piperazine
CAS 522650-58-4C18H20N2O3S
1-[(4-Chlorophenyl)sulfonyl]-4-(phenylacetyl)piperazine chemical structure, C18H19ClN2O3S, CAS 333756-29-9
1-[(4-Chlorophenyl)sulfonyl]-4-(phenylacetyl)piperazine
CAS 333756-29-9C18H19ClN2O3S
2-Phenyl-1-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-ethanone chemical structure, C19H22N2O3S, CAS 333757-26-9
2-Phenyl-1-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-ethanone
CAS 333757-26-9C19H22N2O3S
1-[4-(4-Nitrophenyl)sulfonylpiperazin-1-yl]-2-phenylethanone chemical structure, C18H19N3O5S, CAS 519005-71-1
1-[4-(4-Nitrophenyl)sulfonylpiperazin-1-yl]-2-phenylethanone
CAS 519005-71-1C18H19N3O5S
1-[4-(4-Fluorophenyl)sulfonylpiperazin-1-yl]-2-phenylethanone chemical structure, C18H19FN2O3S, CAS 429620-84-8
1-[4-(4-Fluorophenyl)sulfonylpiperazin-1-yl]-2-phenylethanone
CAS 429620-84-8C18H19FN2O3S
N-[4-[4-(2-Phenylacetyl)piperazin-1-yl]sulfonylphenyl]acetamide chemical structure, C20H23N3O4S, CAS 439939-75-0
N-[4-[4-(2-Phenylacetyl)piperazin-1-yl]sulfonylphenyl]acetamide
CAS 439939-75-0C20H23N3O4S
1-[4-(4-Methoxyphenyl)sulfonylpiperazin-1-yl]-2-phenylethanone chemical structure, C19H22N2O4S, CAS 333756-30-2
1-[4-(4-Methoxyphenyl)sulfonylpiperazin-1-yl]-2-phenylethanone
CAS 333756-30-2C19H22N2O4S
1-(Mesitylsulfonyl)-4-(phenylacetyl)piperazine chemical structure, C21H26N2O3S, CAS 701928-17-8
1-(Mesitylsulfonyl)-4-(phenylacetyl)piperazine
CAS 701928-17-8C21H26N2O3S
1-[4-(Benzenesulfonyl)piperazin-1-yl]-2-(4-chlorophenyl)ethanone chemical structure, C18H19ClN2O3S, CAS 588684-61-1
1-[4-(Benzenesulfonyl)piperazin-1-yl]-2-(4-chlorophenyl)ethanone
CAS 588684-61-1C18H19ClN2O3S
1-[4-(Benzenesulfonyl)piperazin-1-yl]-2-(2-methylphenyl)ethanone chemical structure, C19H22N2O3S, CAS 915875-87-5
1-[4-(Benzenesulfonyl)piperazin-1-yl]-2-(2-methylphenyl)ethanone
CAS 915875-87-5C19H22N2O3S
2-(2-Methoxyphenyl)-1-[4-(phenylsulfonyl)piperazin-1-yl]ethanone chemical structure, C19H22N2O4S, CAS 915888-52-7
2-(2-Methoxyphenyl)-1-[4-(phenylsulfonyl)piperazin-1-yl]ethanone
CAS 915888-52-7C19H22N2O4S
1-[4-[(3,4-Dimethylphenyl)sulfonyl]-1-piperazinyl]-2-(4-methylphenyl)ethanone chemical structure, C21H26N2O3S, CAS 908494-48-4
1-[4-[(3,4-Dimethylphenyl)sulfonyl]-1-piperazinyl]-2-(4-methylphenyl)ethanone
CAS 908494-48-4C21H26N2O3S
2-(4-Aminophenyl)-1-[4-(2-nitrobenzenesulfonyl)piperazin-1-yl]ethan-1-one chemical structure, C18H20N4O5S, CAS 1839343-99-5
2-(4-Aminophenyl)-1-[4-(2-nitrobenzenesulfonyl)piperazin-1-yl]ethan-1-one
CAS 1839343-99-5C18H20N4O5S
2-(4-Aminophenyl)-1-[4-(4-nitrobenzenesulfonyl)piperazin-1-yl]ethan-1-one chemical structure, C18H20N4O5S, CAS 2138556-37-1
2-(4-Aminophenyl)-1-[4-(4-nitrobenzenesulfonyl)piperazin-1-yl]ethan-1-one
CAS 2138556-37-1C18H20N4O5S