Murcko scaffold
Ring system with 3 rings and 20 atoms
24 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 20
- Chemicals
- 24
- With full pages
- 3
Scaffold SMILES
O=C(Nc1cc(-c2ccccc2)cs1)C1CCCCC1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 24 of 24 chemicals
![Isopropyl 2-[(cyclohexylcarbonyl)amino]-4-(4-methoxyphenyl)-3-thiophenecarboxylate chemical structure, C22H27NO4S, CAS 444999-78-4](/s/IDESWZNXTSGZQN-UHFFFAOYSA-N.svg)
Isopropyl 2-[(cyclohexylcarbonyl)amino]-4-(4-methoxyphenyl)-3-thiophenecarboxylate
CAS 444999-78-4C22H27NO4S
![2-{[3-(Ethoxycarbonyl)-4-(4-fluorophenyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid chemical structure, C21H22FNO5S, CAS 312952-04-8](/s/RJFSKMAIQNEYCC-UHFFFAOYSA-N.svg)
2-{[3-(Ethoxycarbonyl)-4-(4-fluorophenyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid
CAS 312952-04-8C21H22FNO5S
![2-{[4-(4-Chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid chemical structure, C21H22ClNO5S, CAS 351000-27-6](/s/ZHTXAJWWCUBDLN-UHFFFAOYSA-N.svg)
2-{[4-(4-Chlorophenyl)-3-(ethoxycarbonyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid
CAS 351000-27-6C21H22ClNO5S
![2-[[3-Ethoxycarbonyl-4-(4-methylphenyl)thiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid chemical structure, C22H25NO5S, CAS 312951-92-1](/s/ANRGOALEWVPWRX-UHFFFAOYSA-N.svg)
2-[[3-Ethoxycarbonyl-4-(4-methylphenyl)thiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid
CAS 312951-92-1C22H25NO5S
![2-{[3-(Methoxycarbonyl)-4-phenylthiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid chemical structure, C20H21NO5S, CAS 350998-82-2](/s/KHPLQEQAOVFHSZ-UHFFFAOYSA-N.svg)
2-{[3-(Methoxycarbonyl)-4-phenylthiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid
CAS 350998-82-2C20H21NO5S
2-((4-(4-Chlorophenyl)-3-(methoxycarbonyl)thiophen-2-yl)carbamoyl)cyclohexanecarboxylic acid
CAS 350999-84-7C20H20ClNO5S
![2-[[4-(4-Bromophenyl)-3-methoxycarbonylthiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid chemical structure, C20H20BrNO5S, CAS 312951-93-2](/s/SREUXJMFLPMDPL-UHFFFAOYSA-N.svg)
2-[[4-(4-Bromophenyl)-3-methoxycarbonylthiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid
CAS 312951-93-2C20H20BrNO5S
![2-[[3-Ethoxycarbonyl-4-(4-methoxyphenyl)thiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid chemical structure, C22H25NO6S, CAS 312951-94-3](/s/RFCNSIJLGGXDMA-UHFFFAOYSA-N.svg)
2-[[3-Ethoxycarbonyl-4-(4-methoxyphenyl)thiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid
CAS 312951-94-3C22H25NO6S
![2-({3-(Methoxycarbonyl)-5-methyl-4-[4-(propan-2-yl)phenyl]thiophen-2-yl}carbamoyl)cyclohexanecarboxylic acid chemical structure, C24H29NO5S, CAS 495375-60-5](/s/GBQHIBGXRULIPB-UHFFFAOYSA-N.svg)
2-({3-(Methoxycarbonyl)-5-methyl-4-[4-(propan-2-yl)phenyl]thiophen-2-yl}carbamoyl)cyclohexanecarboxylic acid
CAS 495375-60-5C24H29NO5S
![2-{[4-(2,5-Dimethylphenyl)-3-(methoxycarbonyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid chemical structure, C22H25NO5S, CAS 444905-60-6](/s/WJGWGNCAMCGDBK-UHFFFAOYSA-N.svg)
2-{[4-(2,5-Dimethylphenyl)-3-(methoxycarbonyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid
CAS 444905-60-6C22H25NO5S
![2-{[4-(4-Fluorophenyl)-5-methyl-3-(propoxycarbonyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid chemical structure, C23H26FNO5S, CAS 494862-58-7](/s/SFMXPEBFSFQEGH-UHFFFAOYSA-N.svg)
2-{[4-(4-Fluorophenyl)-5-methyl-3-(propoxycarbonyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid
CAS 494862-58-7C23H26FNO5S
![2-({[3-(Aminocarbonyl)-5-methyl-4-phenyl-2-thienyl]amino}carbonyl)cyclohexanecarboxylic acid chemical structure, C20H22N2O4S, CAS 492433-73-5](/s/XHEKOUWCXUFASW-UHFFFAOYSA-N.svg)
2-({[3-(Aminocarbonyl)-5-methyl-4-phenyl-2-thienyl]amino}carbonyl)cyclohexanecarboxylic acid
CAS 492433-73-5C20H22N2O4S
![2-{[4-(3,4-Dimethylphenyl)-3-(ethoxycarbonyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid chemical structure, C23H27NO5S, CAS 444998-65-6](/s/QMMPQHZEHLOIKF-UHFFFAOYSA-N.svg)
2-{[4-(3,4-Dimethylphenyl)-3-(ethoxycarbonyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid
CAS 444998-65-6C23H27NO5S
![2-({[3-(Aminocarbonyl)-4-(4-isopropylphenyl)-5-methyl-2-thienyl]amino}carbonyl)cyclohexanecarboxylic acid chemical structure, C23H28N2O4S, CAS 438196-96-4](/s/PYNJLWRXJQEMHX-UHFFFAOYSA-N.svg)
2-({[3-(Aminocarbonyl)-4-(4-isopropylphenyl)-5-methyl-2-thienyl]amino}carbonyl)cyclohexanecarboxylic acid
CAS 438196-96-4C23H28N2O4S
![2-({[3-Cyano-4-(4-methoxyphenyl)-5-methyl-2-thienyl]amino}carbonyl)cyclohexanecarboxylic acid chemical structure, C21H22N2O4S, CAS 522619-15-4](/s/DQAASANCZGVMLL-UHFFFAOYSA-N.svg)
2-({[3-Cyano-4-(4-methoxyphenyl)-5-methyl-2-thienyl]amino}carbonyl)cyclohexanecarboxylic acid
CAS 522619-15-4C21H22N2O4S
![2-{[3-(Methoxycarbonyl)-5-methyl-4-(4-methylphenyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid chemical structure, C22H25NO5S, CAS 445001-86-5](/s/CYGFQQAUVZUPNV-UHFFFAOYSA-N.svg)
2-{[3-(Methoxycarbonyl)-5-methyl-4-(4-methylphenyl)thiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid
CAS 445001-86-5C22H25NO5S
![2-({[4-(2,4-Dimethylphenyl)-3-(ethoxycarbonyl)thien-2-yl]amino}carbonyl)cyclohexanecarboxylic acid chemical structure, C23H27NO5S, CAS 445001-59-2](/s/FIGYAUKROVGBCD-UHFFFAOYSA-N.svg)
2-({[4-(2,4-Dimethylphenyl)-3-(ethoxycarbonyl)thien-2-yl]amino}carbonyl)cyclohexanecarboxylic acid
CAS 445001-59-2C23H27NO5S
![2-{[4-(3,4-Dimethylphenyl)-3-(methoxycarbonyl)-5-methylthiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid chemical structure, C23H27NO5S, CAS 444906-62-1](/s/NARGBWAZRRVHDO-UHFFFAOYSA-N.svg)
2-{[4-(3,4-Dimethylphenyl)-3-(methoxycarbonyl)-5-methylthiophen-2-yl]carbamoyl}cyclohexanecarboxylic acid
CAS 444906-62-1C23H27NO5S
![2-[[3-Methoxycarbonyl-4-(3-methylphenyl)thiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid chemical structure, C21H23NO5S, CAS 445004-24-0](/s/KRQONZAGIJSUPH-UHFFFAOYSA-N.svg)
2-[[3-Methoxycarbonyl-4-(3-methylphenyl)thiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid
CAS 445004-24-0C21H23NO5S
![2-({[3-(Ethoxycarbonyl)-4-(4-fluorophenyl)-5-methyl-2-thienyl]amino}carbonyl)cyclohexanecarboxylic acid chemical structure, C22H24FNO5S, CAS 354539-59-6](/s/MRUUWSYWSAJZEA-UHFFFAOYSA-N.svg)
2-({[3-(Ethoxycarbonyl)-4-(4-fluorophenyl)-5-methyl-2-thienyl]amino}carbonyl)cyclohexanecarboxylic acid
CAS 354539-59-6C22H24FNO5S
![Cyclohexanecarboxylic acid, 2-[[(3-cyano-5-methyl-4-phenyl-2-thienyl)amino]carbonyl]- chemical structure, C20H20N2O3S, CAS 492432-98-1](/s/MWRWKYCNJYRWIB-UHFFFAOYSA-N.svg)
Cyclohexanecarboxylic acid, 2-[[(3-cyano-5-methyl-4-phenyl-2-thienyl)amino]carbonyl]-
CAS 492432-98-1C20H20N2O3S
![2-({[3-(Aminocarbonyl)-4-(4-tert-butylphenyl)-5-methyl-2-thienyl]amino}carbonyl)cyclohexanecarboxylic acid chemical structure, C24H30N2O4S, CAS 495396-00-4](/s/PWXIGFBSWXPZRS-UHFFFAOYSA-N.svg)
2-({[3-(Aminocarbonyl)-4-(4-tert-butylphenyl)-5-methyl-2-thienyl]amino}carbonyl)cyclohexanecarboxylic acid
CAS 495396-00-4C24H30N2O4S
2-((4-(3,4-Dimethylphenyl)-3-(ethoxycarbonyl)-5-methylthiophen-2-yl)carbamoyl)cyclohexanecarboxylic acid
CAS 444905-31-1C24H29NO5S
![2-[[4-(4-Methylphenyl)-3-propan-2-yloxycarbonylthiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid chemical structure, C23H27NO5S, CAS 351001-13-3](/s/VBUWPUVFZHSCHR-UHFFFAOYSA-N.svg)
2-[[4-(4-Methylphenyl)-3-propan-2-yloxycarbonylthiophen-2-yl]carbamoyl]cyclohexane-1-carboxylic acid
CAS 351001-13-3C23H27NO5S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold c1ccc(CSc2nnc(-c3ccccc3)[nH]2)cc1](/scaffold/CBPCFMMAXNCEHC-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccccc3)[nH]2)cc169 chemicals
O=C(Nc1ccccc1)c1ccc(-c2ccccc2)o166 chemicals
O=C1C(N=Nc2ccccc2)C=NN1c1ccccc163 chemicals
O=C(Nc1ccccc1)C1CC(=O)N(c2ccccc2)C149 chemicals
c1ccc(N=Nc2cnn(-c3ccccc3)c2)cc140 chemicals![Scaffold c1ccc(CSc2nnc(-c3ccccn3)[nH]2)cc1](/scaffold/DBVANQGRXKUFCH-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccccn3)[nH]2)cc139 chemicals![Scaffold c1ccc(CSc2nnc(-c3ccncc3)[nH]2)cc1](/scaffold/JTTNDRXETJGQKP-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3ccncc3)[nH]2)cc135 chemicals
O=C(Nc1nc(-c2ccccc2)cs1)c1ccccc131 chemicals![Scaffold O=c1c(NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc1](/scaffold/XHWZVQUKSBVLDH-UHFFFAOYSA-N/structure.svg)
O=c1c(NS(=O)(=O)c2ccccc2)c[nH]n1-c1ccccc130 chemicals![Scaffold O=c1c(N=Cc2ccccc2)c[nH]n1-c1ccccc1](/scaffold/ARHCMYOKQKXAGO-UHFFFAOYSA-N/structure.svg)
O=c1c(N=Cc2ccccc2)c[nH]n1-c1ccccc127 chemicals![Scaffold c1ccc(CSc2nnc(-c3cccnc3)[nH]2)cc1](/scaffold/OUELDRTWHCTFGU-UHFFFAOYSA-N/structure.svg)
c1ccc(CSc2nnc(-c3cccnc3)[nH]2)cc125 chemicals
O=C1CC(NCc2ccccc2)C(=O)N1c1ccccc125 chemicals