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Murcko scaffold

Ring system with 3 rings and 20 atoms

11 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
11
With full pages
3
Scaffold SMILES

O=C1NC(=Nc2ccccn2)SC1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1NC(=Nc2ccccn2)SC1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

(2Z)-5-(4-Chlorobenzyl)-2-(pyridin-2-ylimino)-1,3-thiazolidin-4-one chemical structure, C15H12ClN3OS
(2Z)-5-(4-Chlorobenzyl)-2-(pyridin-2-ylimino)-1,3-thiazolidin-4-one
C15H12ClN3OS
(E)-5-(4-Methylbenzyl)-2-(pyridin-2-ylimino)thiazolidin-4-one chemical structure, C16H15N3OS
(E)-5-(4-Methylbenzyl)-2-(pyridin-2-ylimino)thiazolidin-4-one
C16H15N3OS
(E)-5-(4-Chlorobenzyl)-2-(pyridin-2-ylimino)thiazolidin-4-one chemical structure, C15H12ClN3OS, CAS 1056555-83-9
(E)-5-(4-Chlorobenzyl)-2-(pyridin-2-ylimino)thiazolidin-4-one
CAS 1056555-83-9C15H12ClN3OS
5-(4-Bromobenzyl)-2-(2-pyridinylimino)-1,3-thiazolidin-4-one chemical structure, C15H12BrN3OS, CAS 303093-53-0
5-(4-Bromobenzyl)-2-(2-pyridinylimino)-1,3-thiazolidin-4-one
CAS 303093-53-0C15H12BrN3OS
5-[(3,4-Dichlorophenyl)methyl]-2-[(6-methylpyridin-2-yl)imino]-1,3-thiazolidin-4-one chemical structure, C16H13Cl2N3OS
5-[(3,4-Dichlorophenyl)methyl]-2-[(6-methylpyridin-2-yl)imino]-1,3-thiazolidin-4-one
C16H13Cl2N3OS
5-(4-Methyl-benzyl)-2-[(E)-pyridin-2-ylimino]-thiazolidin-4-one chemical structure, C16H15N3OS, CAS 1056555-78-2
5-(4-Methyl-benzyl)-2-[(E)-pyridin-2-ylimino]-thiazolidin-4-one
CAS 1056555-78-2C16H15N3OS
(Z)-Ethyl 4-((2-((6-methylpyridin-2-yl)imino)-4-oxothiazolidin-5-yl)methyl)benzoate chemical structure, C19H19N3O3S, CAS 497942-76-4
(Z)-Ethyl 4-((2-((6-methylpyridin-2-yl)imino)-4-oxothiazolidin-5-yl)methyl)benzoate
CAS 497942-76-4C19H19N3O3S
Ethyl 4-{[(2Z)-2-[(6-methylpyridin-2-yl)imino]-4-oxo-1,3-thiazolidin-5-yl]methyl}benzoate chemical structure, C19H19N3O3S
Ethyl 4-{[(2Z)-2-[(6-methylpyridin-2-yl)imino]-4-oxo-1,3-thiazolidin-5-yl]methyl}benzoate
C19H19N3O3S
(E)-5-(3,4-Dichlorobenzyl)-2-((6-methylpyridin-2-yl)imino)thiazolidin-4-one chemical structure, C16H13Cl2N3OS, CAS 496021-01-3
(E)-5-(3,4-Dichlorobenzyl)-2-((6-methylpyridin-2-yl)imino)thiazolidin-4-one
CAS 496021-01-3C16H13Cl2N3OS
5-[(2,6-Dichlorophenyl)methyl]-2-(2-pyridinylamino)-4(5H)-thiazolone chemical structure, C15H11Cl2N3OS, CAS 618393-83-2
5-[(2,6-Dichlorophenyl)methyl]-2-(2-pyridinylamino)-4(5H)-thiazolone
CAS 618393-83-2C15H11Cl2N3OS
Ethyl 4-[[(2E)-2-[(6-methyl-2-pyridinyl)imino]-4-oxo-1,3-thiazolidin-5-yl]methyl]benzoate chemical structure, C19H19N3O3S
Ethyl 4-[[(2E)-2-[(6-methyl-2-pyridinyl)imino]-4-oxo-1,3-thiazolidin-5-yl]methyl]benzoate
C19H19N3O3S